Evaluating the Written Work of Others: One Way Economics Students Can Learn to Write

The authors present a series of writing assignments that teaches students how to evaluate and critique the written economic work of others. The foundation text is McCloskey’s (2000) Economical Writing. The students’ dialogues with McCloskey, with each other, and with the authors of the pieces they evaluate sharpen their understanding of, and ability to use, language as an instrument of economic thought. Interviews with former students identify specific benefits from the student perspective of this approach. The authors show how the assignment series can be modified in several ways and how the general approach, as well as the foundation text, can be used in different economics courses

Exploring explicit and implicit correlates of early anti-social fire exposure and everyday fire use in adulthood

Purpose This study aims to explore whether early anti-social fire exposure (ASFE) is associated with how adults engage with fire and how they view fire. Design/methodology/approach An opportunistic sample (N = 326) was recruited. Participants completed an online survey exploring ASFE, fire use, strength of fire-beliefs and interest in/attitudes supportive of fire. Additionally, implicit fire bias was measured using the affect misattribution procedure (AMP). Findings Participants with ASFE engaged with more criminalised fire use as adults. They also scored higher on fire interest and general fire beliefs and showed an implicit dislike of fire stimuli, compared to non-exposed participants (although differences in fire use were not statistically significant when gender was accounted for). Males also had higher levels of fire interest, held stronger fire related beliefs and were more likely to have been exposed to ASFE during childhood. However, there were no gender differences in fire use or on the implicit task. Research limitations/implications The findings have practical application, namely in relation to early intervention and rehabilitative approaches. However, a limitation is that participants’ cultural background were not accounted for. Additionally, we advise caution in interpreting the implicit results and call for further research. Social implications The need for better early interventions for young people is highlighted, along with better screening which, currently, is unstandardised and inconsistent across the country (Foster, 2020). This demands a community-engagement approach. Originality/value This is the first study to explore type of early exposure to fire. It is also the first to adopt the AMP as a measure of implicit fire-bias

Increased Placental Cell Senescence and Oxidative Stress in Women with Pre-Eclampsia and Normotensive Post-Term Pregnancies

Up to 11% of pregnancies extend to post-term with adverse obstetric events linked to pregnancies over 42 weeks. Oxidative stress and senescence (cells stop growing and dividing by irreversibly arresting their cell cycle and gradually ageing) can result in diminished cell function. There are no detailed studies of placental cell senescence markers across a range of gestational ages, although increased levels have been linked to pre-eclampsia before full term. This study aimed to determine placental senescence and oxidative markers across a range of gestational ages in women with uncomplicated pregnancies and those with a diagnosis of pre-eclampsia. Placentae were obtained from 37 women with uncomplicated pregnancies of 37–42 weeks and from 13 cases of pre-eclampsia of 31+2–41+2 weeks. The expression of markers of senescence, oxidative stress, and antioxidant defence (tumour suppressor protein p16INK4a, kinase inhibitor p21, interleukin-6 (IL-6), NADPH oxidase 4 (NOX4), glutathione peroxidases 1, 3, and 4 (GPx1, GPx3, and GPx4), placental growth factor (PlGF), and soluble fms-like tyrosine kinase-1 (sFlt-1)) genes was measured (quantitative real-time PCR). Protein abundance of p16INK4a, IL-6, NOX4, 8-hydroxy-2′-deoxy-guanosine (8-OHdG), and PlGF was assessed by immunocytochemistry. Placental NOX4 protein was higher in post-term than term deliveries and further increased by pre-eclampsia (p < 0.05 for all). P21 expression was higher in post-term placentae (p = 0.012) and in pre-eclampsia (p = 0.04), compared to term. Placental P16INK4a protein expression was increased post-term, compared to term (p = 0.01). In normotensive women, gestational age at delivery was negatively associated with GPx4 and PlGF (mRNA and protein) (p < 0.05 for all), whereas a positive correlation was seen with placental P21, NOX4, and P16INK4a (p < 0.05 for all) expression. Markers of placental oxidative stress and senescence appear to increase as gestational age increases, with antioxidant defences diminishing concomitantly. These observations increase our understanding of placental health and may contribute to assessment of the optimal gestational age for delivery

Increased Placental Cell Senescence and Oxidative Stress in Women with Pre-Eclampsia and Normotensive Post-Term Pregnancies

From MDPI via Jisc Publications RouterHistory: accepted 2021-07-02, pub-electronic 2021-07-07Publication status: PublishedFunder: British Heart Foundation; Grant(s): FS/15/32/31604Up to 11% of pregnancies extend to post-term with adverse obstetric events linked to pregnancies over 42 weeks. Oxidative stress and senescence (cells stop growing and dividing by irreversibly arresting their cell cycle and gradually ageing) can result in diminished cell function. There are no detailed studies of placental cell senescence markers across a range of gestational ages, although increased levels have been linked to pre-eclampsia before full term. This study aimed to determine placental senescence and oxidative markers across a range of gestational ages in women with uncomplicated pregnancies and those with a diagnosis of pre-eclampsia. Placentae were obtained from 37 women with uncomplicated pregnancies of 37–42 weeks and from 13 cases of pre-eclampsia of 31+2–41+2 weeks. The expression of markers of senescence, oxidative stress, and antioxidant defence (tumour suppressor protein p16INK4a, kinase inhibitor p21, interleukin-6 (IL-6), NADPH oxidase 4 (NOX4), glutathione peroxidases 1, 3, and 4 (GPx1, GPx3, and GPx4), placental growth factor (PlGF), and soluble fms-like tyrosine kinase-1 (sFlt-1)) genes was measured (quantitative real-time PCR). Protein abundance of p16INK4a, IL-6, NOX4, 8-hydroxy-2′-deoxy-guanosine (8-OHdG), and PlGF was assessed by immunocytochemistry. Placental NOX4 protein was higher in post-term than term deliveries and further increased by pre-eclampsia (p 0.05 for all). P21 expression was higher in post-term placentae (p = 0.012) and in pre-eclampsia (p = 0.04), compared to term. Placental P16INK4a protein expression was increased post-term, compared to term (p = 0.01). In normotensive women, gestational age at delivery was negatively associated with GPx4 and PlGF (mRNA and protein) (p 0.05 for all), whereas a positive correlation was seen with placental P21, NOX4, and P16INK4a (p 0.05 for all) expression. Markers of placental oxidative stress and senescence appear to increase as gestational age increases, with antioxidant defences diminishing concomitantly. These observations increase our understanding of placental health and may contribute to assessment of the optimal gestational age for delivery

The environmental effectiveness of the Higher Level Stewardship scheme; resurveying the baseline agreement monitoring sample to quantify change between 2009 and 2016. Full technical final report

Agri-environment schemes (AES) are one of the most significant mechanism for delivering environmental policy within England, both in terms of expenditure and coverage of land. AES are multi-objective, primarily addressing conservation of wildlife, landscapes and the historic environment and providing public access as well as addressing broader environmental issues such as climate change and flood management. This project contributes to evaluation of the Higher Level Stewardship (HLS) AES, which was designed to achieve the highest standards of environmental management and target features of the greatest conservation value, including Sites of Special Scientific Interest (SSSIs). Monitoring is a key element of scheme delivery in order to assess the efficacy of AES, and determine which factors contribute to successful AES outcomes. Here, we resurveyed a sample of HLS agreements (surveyed 6-7 years previously), to assess environmental outcomes and in particular change in plant communities over time in relation to AES management. The assessment of change over time allowed the effects of AES management to be quantified against defined objectives, as opposed to drawing conclusions from a single assessment where the conservation value of land entered into an AES can be confounded with AES management effects

Effects of antiplatelet therapy on stroke risk by brain imaging features of intracerebral haemorrhage and cerebral small vessel diseases: subgroup analyses of the RESTART randomised, open-label trial

Background Findings from the RESTART trial suggest that starting antiplatelet therapy might reduce the risk of recurrent symptomatic intracerebral haemorrhage compared with avoiding antiplatelet therapy. Brain imaging features of intracerebral haemorrhage and cerebral small vessel diseases (such as cerebral microbleeds) are associated with greater risks of recurrent intracerebral haemorrhage. We did subgroup analyses of the RESTART trial to explore whether these brain imaging features modify the effects of antiplatelet therapy

Statin Treatment Increases Lifespan and Improves Cardiac Health in Drosophila by Decreasing Specific Protein Prenylation

Statins such as simvastatin are 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors and standard therapy for the prevention and treatment of cardiovascular diseases in mammals. Here we show that simvastatin significantly increased the mean and maximum lifespan of Drosophila melanogaster (Drosophila) and enhanced cardiac function in aging flies by significantly reducing heart arrhythmias and increasing the contraction proportion of the contraction/relaxation cycle. These results appeared independent of internal changes in ubiquinone or juvenile hormone levels. Rather, they appeared to involve decreased protein prenylation. Simvastatin decreased the membrane association (prenylation) of specific small Ras GTPases in mice. Both farnesyl (L744832) and type 1 geranylgeranyl transferase (GGTI-298) inhibitors increased Drosophila lifespan. These data are the most direct evidence to date that decreased protein prenylation can increase cardiac health and lifespan in any metazoan species, and may explain the pleiotropic (non-cholesterol related) health effects of statins