544 research outputs found
Evaluation of electrospray differential mobility analysis for virus particle analysis: Potential applications for biomanufacturing.
The technique of electrospray differential mobility analysis (ES-DMA) was examined as a potential potency assay for routine virus particle analysis in biomanufacturing environments (e.g., evaluation of vaccines and gene delivery products for lot release) in the context of the International Committee of Harmonisation (ICH) Q2 guidelines. ES-DMA is a rapid particle sizing method capable of characterizing certain aspects of the structure (such as capsid proteins) and obtaining complete size distributions of viruses and virus-like particles. It was shown that ES-DMA can distinguish intact virus particles from degraded particles and measure the concentration of virus particles when calibrated with nanoparticles of known concentration. The technique has a measurement uncertainty of ≈20%, is linear over nearly 3 orders of magnitude, and has a lower limit of detection of ≈10(9)particles/mL. This quantitative assay was demonstrated for non-enveloped viruses. It is expected that ES-DMA will be a useful method for applications involving production and quality control of vaccines and gene therapy vectors for human use
Quasiparticle relaxation dynamics in cuprates and lifetimes of low-energy states: Femtosecond data from underdoped to overdoped YBCO and mercury compounds
We show that low-energy spectral features in the cuprates can be separated
into different components by the measurement of the recombination dynamics of
different low-energy excitations in real-time using femtosecond laser
spectroscopy. Quasiparticle (QP) recombination across the gap and intra-gap
localized state relaxation processes exhibit qualitatively different time- and
temperature-dependences. The relaxation measurements also show the existence of
two distinct coexisting energy gaps near optimum doping and in the overdoped
region, one more or less temperature independent (which exists above and below
Tc) and one which closes at Tc in a mean-field like fashion. Thus systematic
studies of QP recombination as a function of doping and temperature suggest
that the ground state of the cuprates is a mixed Boson-Fermion system with
localised states present over the entire region of the phase diagram.Comment: 4 pages, acepted for publication in Physica C, invited paper given at
M2S, Feb. 20 - 25, 2000, Houston, US
Anomalous Behavior Of The Complex Conductivity Of Y_{1-x}Pr_xBa_2Cu_3O_7 Observed With THz Spectroscopy
We have measured the electrodynamic properties of Y_{1-x}Pr_xBa_2Cu_3O_7
single crystal thin films as a function of temperature using coherent
THz-time-domain spectroscopy. We obtain directly the complex conductivity
, the London penetration depth , the
plasma frequency , and the quasiparticle scattering rate . We
find that drops exponentially rapidly with below the critical
temperature in {\em all} the superconducting samples, implying that this
behavior is a {\em signature} of high- superconductivity. The plasma
frequency decreases with increasing Pr content, providing evidence that Pr
depletes carriers, leaving the CuO planes {\em underdoped}. Both the
conductivity in the THz region and the dc resistivity yield evidence for the
opening of a spin gap {\em above} .Comment: 9 pages, REVTEX 3.
The Danish Shoulder Arthroplasty Registry: clinical outcome and short-term survival of 2,137 primary shoulder replacements
The Danish Shoulder Arthroplasty Registry (DSR) was established in 2004. Data are reported electronically by the surgeons. Patient-reported outcome is collected 10–14 months postoperatively using the Western Ontario osteoarthritis of the shoulder index (WOOS). 2,137 primary shoulder arthroplasties (70% women) were reported to the registry between January 2006 and December 2008. Mean age at surgery was 69 years (SD 12). The most common indications were a displaced proximal humeral fracture (54%) or osteoarthritis (30%). 61% were stemmed hemiarthroplasties, 28% resurfacing hemiarthroplasties, 8% reverse shoulder arthroplasties, and 3% total arthroplasties. Median WOOS was 59% (IQR: 37–82). 5% had been revised by the end of June 2010. The most frequent indications for revision were dislocation or glenoid attrition
Ultrafast quasiparticle relaxation dynamics in normal metals and heavy fermion materials
We present a detailed theoretical study of the ultrafast quasiparticle
relaxation dynamics observed in normal metals and heavy fermion materials with
femtosecond time-resolved optical pump-probe spectroscopy. For normal metals, a
nonthermal electron distribution gives rise to a temperature (T) independent
electron-phonon relaxation time at low temperatures, in contrast to the
T^{-3}-divergent behavior predicted by the two-temperature model. For heavy
fermion compounds, we find that the blocking of electron-phonon scattering for
heavy electrons within the density-of-states peak near the Fermi energy is
crucial to explain the rapid increase of the electron-phonon relaxation time
below the Kondo temperature. We propose the hypothesis that the slower Fermi
velocity compared to the sound velocity provides a natural blocking mechanism
due to energy and momentum conservation laws.Comment: 10 pages, 11 figure
Comparison of s- and d-wave gap symmetry in nonequilibrium superconductivity
Recent application of ultrafast pump/probe optical techniques to
superconductors has renewed interest in nonequilibrium superconductivity and
the predictions that would be available for novel superconductors, such as the
high-Tc cuprates. We have reexamined two of the classical models which have
been used in the past to interpret nonequilibrium experiments with some
success: the mu* model of Owen and Scalapino and the T* model of Parker.
Predictions depend on pairing symmetry. For instance, the gap suppression due
to excess quasiparticle density n in the mu* model, varies as n^{3/2} in d-wave
as opposed to n for s-wave. Finally, we consider these models in the context of
S-I-N tunneling and optical excitation experiments. While we confirm that
recent pump/probe experiments in YBCO, as presently interpreted, are in
conflict with d-wave pairing, we refute the further claim that they agree with
s-wave.Comment: 14 pages, 11 figure
Kinetic Inductance and Penetration Depth of Thin Superconducting Films Measured by THz Pulse Spectroscopy
We measure the transmission of THz pulses through thin films of YBCO at
temperatures between 10K and 300K. The pulses possess a useable bandwidth
extending from 0.1 -- 1.5 THz (3.3 cm^-1 -- 50 cm^-1). Below T_c we observe
pulse reshaping caused by the kinetic inductance of the superconducting charge
carriers. From transmission data, we extract values of the London penetration
depth as a function of temperature, and find that it agrees well with a
functional form (\lambda(0)/\lambda(T))^2 = 1 - (T/T_c)^{\alpha}, where
\lambda(0) = 148 nm, and \alpha = 2. *****Figures available upon request*****Comment: 7 Pages, LaTe
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