Machine Learning in Colorectal Cancer Risk Prediction from Routinely Collected Data: A Review.

The inclusion of machine-learning-derived models in systematic reviews of risk prediction models for colorectal cancer is rare. Whilst such reviews have highlighted methodological issues and limited performance of the models included, it is unclear why machine-learning-derived models are absent and whether such models suffer similar methodological problems. This scoping review aims to identify machine-learning models, assess their methodology, and compare their performance with that found in previous reviews. A literature search of four databases was performed for colorectal cancer prediction and prognosis model publications that included at least one machine-learning model. A total of 14 publications were identified for inclusion in the scoping review. Data was extracted using an adapted CHARM checklist against which the models were benchmarked. The review found similar methodological problems with machine-learning models to that observed in systematic reviews for non-machine-learning models, although model performance was better. The inclusion of machine-learning models in systematic reviews is required, as they offer improved performance despite similar methodological omissions; however, to achieve this the methodological issues that affect many prediction models need to be addressed

Effect of yoga on pulse rate variability measured from a venous pressure waveform

The benefits of yoga have been studied in different fields, from chronic health conditions to mental disorders, showing that it can help to improve the overall health. In particular, it has been proven that yoga also improves the autonomic function. Heart rate variability (HRV) at rest is commonly used as a non-invasive measure of autonomic regulation of heart rate. Alternatively, pulse rate variability (PRV) has been proposed as a surrogate of HRV. VoluMetrix has developed a novel technology that captures venous waveforms via sensors on the volar aspect of the wrist, called NIVAband. This study aims to assess the effect of yoga in the autonomic nervous system by analyzing the PRV obtained from the NIVA signal. Temporal (statistics of the normal-to-normal intervals), spectral (power in low and high frequency bands) and nonlinear (lagged Poincaré Plot analysis) parameters are analyzed before and after a yoga session in 20 healthy volunteers. The PRV analysis shows an increase in parameters related to parasympathetic activity and overall variability, and a decrease in parameters related to sympathetic activity and mean heart rate. These results support the beneficial effect of yoga in autonomic nervous system, increasing the parasympathetic activity

The benefits and challenges of embedding specialist palliative care teams within homeless hostels to enhance support and learning: Perspectives from palliative care teams and hostel staff.

BACKGROUND: People residing in UK homeless hostels experience extremely high rates of multi-morbidity, frailty and age-related conditions at a young age. However, they seldom receive palliative care with the burden of support falling to hostel staff. AIM: To evaluate a model embedding palliative specialists, trained as 'homelessness champions', into hostels for two half-days a month to provide support to staff and residents and facilitate a multidisciplinary approach to care. DESIGN: An exploratory qualitative design. SETTING/PARTICIPANTS: Four homeless hostels in London, UK, including nine hostel managers/support staff and seven palliative care specialists (five nurses and two social workers). RESULTS: Benefits to introducing the model included: developing partnership working between hostel staff and palliative care specialists, developing a holistic palliative ethos within the hostels and improving how hostel staff seek support and connect with local external services. Challenges to implementation included limited time and resources, and barriers related to primary care. CONCLUSION: This is the first evaluation of embedding palliative care specialists within homeless hostels. Inequity in health and social care access was highlighted with evidence of benefit of this additional support for both hostel staff and residents. Considering COVID-19, future research should explore remote ways of working including providing in-reach support to homelessness services from a range of services and organisations

Identification of the major proteins of an immune modulating fraction from adult Fasciola hepatica released by Nonidet P40

Fasciola hepatica NP-40 released antigens (FhTeg) exhibit potent Th1 immunosuppressive properties in vitro and in vivo. However, the protein composition of this active fraction, responsible for Th1 immune modulatory activity, has yet to be resolved. Therefore, FhTeg, a Nonidet P-40 extract, was subjected to a proteomic analysis in order to identify individual protein components. This was performed using an in house F. hepatica EST database following 2D electrophoresis combined with de novo sequencing based mass spectrometry. The identified proteins, a mixture of excretory/secretory and membrane-associated proteins, are associated with stress response and chaperoning, energy metabolism and cytoskeletal components. The immune modulatory properties of these identified protein(s) is discussed and HSP70 from F. hepatica is highlighted as a potential host immune modulator for future study

The Geysers Geothermal Field Update1990/2010

In this report, we have presented data in four sections: (1) THE GEYSERS HISTORICAL UPDATE 1990-2010 - A historical update of the primary developments at The Geysers between 1990 and 2010 which uses as its start point Section IIA of the Monograph - 'Historical Setting and History of Development' that included articles by James Koenig and Susan Hodgson. (2) THE GEYSERS COMPREHENSIVE REFERENCE LIST 1990-2010 - In this section we present a rather complete list of technical articles and technical related to The Geysers that were issued during the period 1990-2010. The list was compiled from many sources including, but not limited to scientific journals and conference proceedings. While the list was prepared with care and considerable assistance from many geothermal colleagues, it is very possible that some papers could have been missed and we apologize to their authors in advance. The list was subdivided according to the following topics: (1) Field characterization; (2) Drilling; (3) Field development and management; (4) Induced seismicity; (5) Enhanced Geothermal Systems; (6) Power production and related issues; (7) Environment-related issues; and (8) Other topics. (3) GRC 2010 ANNUAL MEETING GEYSERS PAPERS - Included in this section are the papers presented at the GRC 2010 Annual Meeting that relate to The Geysers. (4) ADDITIONAL GEYSERS PAPERS 1990-2010 - Eighteen additional technical papers were included in this publication in order to give a broad background to the development at The Geysers after 1990. The articles issued during the 1990-2010 period were selected by colleagues considered knowledgeable in their areas of expertise. We forwarded the list of references given in Section 2 to them asking to send us with their selections with a preference, because of limited time, to focus on those papers that would not require lengthy copyright approval. We then chose the articles presented in this section with the purpose of providing the broadest possible view across all technical fields, as related to The Geysers steam-dominated geothermal system. The Geysers has seen many fundamental changes between 1990-2010 and yet the geothermal resource seems still to be robust to the extent that, long after its anticipated life span, we are seeing new geothermal projects being developed on the north and west peripheries of the field. It is hoped that this report provides a focused data source particularly for those just starting their geothermal careers, as well as those who have been involved in the interesting and challenging field of geothermal energy for many years. Despite many hurdles The Geysers has continued to generate electrical power for 50 years and its sustainability has exceeded many early researchers expectations. It also seems probable that, with the new projects described above, generation will continue for many years to come. The success of The Geysers is due to the technical skills and the financial acumen of many people, not only over the period covered by this report (1990-2010), but since the first kilowatt of power was generated in 1960. This Special Report celebrates those 50 years of geothermal development at The Geysers and attempts to document the activities that have brought success to the project so that a permanent record can be maintained. It is strongly hoped and believed that a publication similar to this one will be necessary in another 20 years to document further activities in the field

The significance of motivation in student-centred learning : a reflective case study

The theoretical underpinnings of student-centred learning suggest motivation to be an integral component. However, lack of clarification of what is involved in motivation in education often results in unchallenged assumptions that fail to recognise that what motivates some students may alienate others. This case study, using socio-cognitive motivational theory to analyse previously collected data, derives three fuzzy propositions which, collectively, suggest that motivation interacts with the whole cycle of episodes in the teachinglearning process. It argues that the development of the higherlevel cognitive competencies that are implied by the term, student-centred learning, must integrate motivational constructs such as goal orientation, volition, interest and attributions into pedagogical practices

Towards delineating functions within the fasciola secreted cathepsin L protease family by integrating in vivo based sub-proteomics and phylogenetics

BACKGROUND: Fasciola hepatica, along with Fasciola gigantica, is the causative agent of fasciolosis, a foodborne zoonotic disease affecting grazing animals and humans worldwide. Pathology is directly related to the release of parasite proteins that facilitate establishment within the host. The dominant components of these excretory-secretory (ES) products are also the most promising vaccine candidates, the cathepsin L (Cat L) protease family. METHODOLOGY/PRINCIPAL FINDINGS: The sub-proteome of Cat L proteases from adult F. hepatica ES products derived from in vitro culture and in vivo from ovine host bile were compared by 2-DE. The individual Cat L proteases were identified by tandem mass spectrometry with the support of an in-house translated liver fluke EST database. The study reveals plasticity within the CL1 clade of Cat L proteases; highlighted by the identification of a novel isoform and CL1 sub-clade, resulting in a new Cat L phylogenetic analysis including representatives from other adult Cat L phylogenetic clades. Additionally, for the first time, mass spectrometry was shown to be sufficiently sensitive to reveal single amino acid polymorphisms in a resolved 2-DE protein spot derived from pooled population samples. CONCLUSIONS/SIGNIFICANCE: We have investigated the sub-proteome at the population level of a vaccine target family using the Cat L proteases from F. hepatica as a case study. We have confirmed that F. hepatica exhibits more plasticity in the expression of the secreted CL1 clade of Cat L proteases at the protein level than previously realised. We recommend that superfamily based vaccine discovery programmes should screen parasite populations from different host populations and, if required, different host species via sub-proteomic assay in order to confirm the relative expression at the protein level prior to the vaccine development phase