Efficient third harmonic generation in photonic nanowires

In a photonic nanowire the strong optical confinement allows for the phase matching of nonlinear interactions that would not normally be phase matched, while the large longitudinal component of the electric field serves to further enhance the effective nonlinearity. Thus such waveguides are good choices for studying nonlinear effects such as third harmonic generation. In this paper we analyse third harmonic generation analytically and present the criteria for optimal harmonic generation. In addition we analyse the inverse process of 1/3 harmonic generation and show that efficient parametric amplifiers can be made which would be a high brightness source of entangled photons for producing GHZ states

Novel research translates to clinical cases of schizophrenic and cocaine psychosis

Pharmacotherapies for schizophrenic and cocaine psychoses are complex but similar because of similarities in their brain neurochemistry and behavioral outcomes. Their neurochemical neuronal mechanisms of action, as shown in preclinical and clinical studies, involve primarily dopaminergic dysfunction and, secondarily, neuroadaptive effects that seem to involve central serotonergic function. Behavioral outcomes of both disorders include hyperactivity and antipsychotic medications can ameliorate psychotic symptoms. Patients with both disorders often arrive at emergency departments and present floridly psychotic with a predominance of positive symptoms, often prompting physicians to select a typical antipsychotic medication such as haloperidol. While this has become conventional wisdom, we believe that to use an atypical antipsychotic medication, such as risperidone, in the treatment of both psychoses is quite rational for long-term management of both positive and negative symptoms. Also, controlled clinical studies have shown that risperidone, an atypical antipsychotic medication, is successful in the treatment of cocaine dependence and withdrawal (Smelson et al 1997, 2002; Grabowski et al 2000). Furthermore, the availability and effectiveness of long-acting risperidone in injectable form opens new possibilities for the long-term management of both disorders. In this paper, we present data which show that the use of risperidone is plausible for effective pharmacotherapy of schizophrenic and cocaine psychoses

Local dynamics and gravitational collapse of a self-gravitating magnetized Fermi gas

We use the Bianchi-I spacetime to study the local dynamics of a magnetized self-gravitating Fermi gas. The set of Einstein-Maxwell field equations for this gas becomes a dynamical system in a 4-dimensional phase space. We consider a qualitative study and examine numeric solutions for the degenerate zero temperature case. All dynamic quantities exhibit similar qualitative behavior in the 3-dimensional sections of the phase space, with all trajectories reaching a stable attractor whenever the initial expansion scalar H_{0} is negative. If H_{0} is positive, and depending on initial conditions, the trajectories end up in a curvature singularity that could be isotropic(singular "point") or anisotropic (singular "line"). In particular, for a sufficiently large initial value of the magnetic field it is always possible to obtain an anisotropic type of singularity in which the "line" points in the same direction of the field.Comment: 6 pages, 3 figures (accepted in General Relativity and Gravitation

Strong deflection limit of black hole gravitational lensing with arbitrary source distances

The gravitational field of supermassive black holes is able to strongly bend light rays emitted by nearby sources. When the deflection angle exceeds $\pi$, gravitational lensing can be analytically approximated by the so-called strong deflection limit. In this paper we remove the conventional assumption of sources very far from the black hole, considering the distance of the source as an additional parameter in the lensing problem to be treated exactly. We find expressions for critical curves, caustics and all lensing observables valid for any position of the source up to the horizon. After analyzing the spherically symmetric case we focus on the Kerr black hole, for which we present an analytical 3-dimensional description of the higher order caustic tubes.Comment: 20 pages, 8 figures, appendix added. In press on Physical Review

Analysing the Transverse Structure of the Relativistic Jets of AGN

This paper describes a method of fitting total intensity and polarization profiles in VLBI images of astrophysical jets to profiles predicted by a theoretical model. As an example, the method is used to fit profiles of the jet in the Active Galactic Nucleus Mrk501 with profiles predicted by a model in which a cylindrical jet of synchrotron plasma is threaded by a magnetic field with helical and disordered components. This fitting yields model Stokes Q profiles that agree with the observed profiles to within the 1-2 \sigma uncertainties; the I model and observed profiles are overall not in such good agreement, with the model I profiles being generally more symmetrical than the observed profiles. Consistent fitting results are obtained for profiles derived from 6cm VLBI images at two distances from the core, and also for profiles obtained for different wavelengths at a single location in the VLBI jet. The most striking success of the model is its ability to reproduce the spine-sheath polarization structure observed across the jet. Using the derived viewing angle in the jet rest frame, \delta' approximately 83 degrees, together with a superluminal speed reported in the literature, \beta apparent = 3.3, yields a solution for the viewing angle and velocity of the jet in the observer's frame \delta degrees and \beta approximately 0.96. Although these results for Mrk501 must be considered tentative, the combined analysis of polarization profiles and apparent component speeds holds promise as a means of further elucidating the magnetic field structures and other parameters of parsec-scale AGN jets

Universal upper limit on inflation energy scale from cosmic magnetic field

Recently observational lower bounds on the strength of cosmic magnetic fields were reported, based on gamma-ray flux from distant blazars. If inflation is responsible for the generation of such magnetic fields then the inflation energy scale is bounded from above as rho_{inf}^{1/4} < 2.5 times 10^{-7}M_{Pl} times (B_{obs}/10^{-15}G)^{-2} in a wide class of inflationary magnetogenesis models, where B_{obs} is the observed strength of cosmic magnetic fields. The tensor-to-scalar ratio is correspondingly constrained as r< 10^{-19} times (B_{obs}/10^{-15}G)^{-8}. Therefore, if the reported strength B_{obs} \geq 10^{-15}G is confirmed and if any signatures of gravitational waves from inflation are detected in the near future, then our result indicates some tensions between inflationary magnetogenesis and observations.Comment: 12pages, v2: several discussions and references added, version accepted for publication by JCA

Magneto-optical evidence of double exchange in a percolating lattice

Substituting $Eu$ by $Ca$ in ferromagnetic $EuB_6$ leads to a percolation limited magnetic ordering. We present and discuss magneto-optical data of the $Eu_{1-x}Ca_{x}B_6$ series, based on measurements of the reflectivity $R(\omega)$ from the far infrared up to the ultraviolet, as a function of temperature and magnetic field. Via the Kramers-Kronig transformation of $R(\omega)$ we extract the complete absorption spectra of samples with different values of $x$. The change of the spectral weight in the Drude component by increasing the magnetic field agrees with a scenario based on the double exchange model, and suggests a crossover from a ferromagnetic metal to a ferromagnetic Anderson insulator upon increasing $Ca$-content at low temperatures.Comment: 10 pages, 3 figure

On the orientation of the Sagittarius A* system

The near-infrared emission from the black hole at the Galactic center (Sgr A*) has unique properties. The most striking feature is a suggestive periodic sub-structure that has been observed in a couple of flares so far. Using near-infrared polarimetric observations and modelling the quasi-periodicity in terms of an orbiting blob, we try to constrain the three dimensional orientation of the Sgr A* system. We report on so far unpublished polarimetric data from 2003. They support the observations of a roughly constant mean polarization angle of 60 degr \pm 20 degr from 2004-2006. Prior investigations of the 2006 data are deepened. In particular, the blob model fits are evaluated such that constraints on the position angle of Sgr A* can be derived. Confidence contours in the position-inclination angle plane are derived. On a 3sigma level the position angle of the equatorial plane normal is in the range 60 degr - 108 degr (east of north) in combination with a large inclination angle. This agrees well with recent independent work in which radio spectral/morphological properties of Sgr A* and X-ray observations, respectively, have been used. However, the quality of the presently available data and the uncertainties in our model bring some ambiguity to our conclusions.Comment: 10 pages, 4 figures; Research Note accepted by A&A for publicatio

An integrated genomic analysis of lung cancer reveals loss of DUSP4 in EGFR-mutant tumors.

To address the biological heterogeneity of lung cancer, we studied 199 lung adenocarcinomas by integrating genome-wide data on copy number alterations and gene expression with full annotation for major known somatic mutations in this cancer. This showed non-random patterns of copy number alterations significantly linked to EGFR and KRAS mutation status and to distinct clinical outcomes, and led to the discovery of a striking association of EGFR mutations with underexpression of DUSP4, a gene within a broad region of frequent single-copy loss on 8p. DUSP4 is involved in negative feedback control of EGFR signaling, and we provide functional validation for its role as a growth suppressor in EGFR-mutant lung adenocarcinoma. DUSP4 loss also associates with p16/CDKN2A deletion and defines a distinct clinical subset of lung cancer patients. Another novel observation is that of a reciprocal relationship between EGFR and LKB1 mutations. These results highlight the power of integrated genomics to identify candidate driver genes within recurrent broad regions of copy number alteration and to delineate distinct oncogenetic pathways in genetically complex common epithelial cancers