Duration judgements in patients with schizophrenia

Background. The ability to encode time cues underlies many cognitive processes. In the light of schizophrenic patients' compromised cognitive abilities in a variety of domains, it is noteworthy that there are numerous reports of these patients displaying impaired timing abilities. However, the timing intervals that patients have been evaluated on in prior studies vary considerably in magnitude (e.g. 1 s, 1 min, 1 h etc.). Method. In order to obviate differences in abilities in chronometric counting and place minimal demands on cognitive processing, we chose tasks that involve making judgements about brief durations of time (<1 s). Results. On a temporal generalization task, patients were less accurate than controls at recognizing a standard duration. The performance of patients was also significantly different from controls on a temporal bisection task, in which participants categorized durations as short or long. Although time estimation may be closely intertwined with working memory, patients' working memory as measured by the digit span task did not correlate significantly with their performance on the duration judgement tasks. Moreover, lowered intelligence scores could not completely account for the findings. Conclusions. We take these results to suggest that patients with schizophrenia are less accurate at estimating brief time periods. These deficits may reflect dysfunction of biopsychological timing processes

Optimism and Lipid Profiles in Midlife: A 15-Year Study of Black and White Adults

Introduction Optimism is associated with better cardiovascular health, yet little is known about the underlying mechanisms and whether protective relationships are consistently observed across diverse groups. This study examines optimism\u27s association with lipid profiles over time and separately among Black and White men and women. Methods Data were from 3,206 middle-aged adults in the Coronary Artery Risk Development in Young Adults study. Optimism was measured in 2000–2001 using the Revised Life Orientation Test. Triglyceride, total cholesterol, high-density lipoprotein cholesterol, and low-density lipoprotein cholesterol measurements were obtained at 5-year intervals through 2015–2016. Linear mixed models evaluated relationships between optimism and lipids, adjusting for covariates, including prebaseline lipids. Subgroup differences were examined using interaction terms and stratification. All analyses were conducted in 2020. Results Higher optimism was associated with both lower baseline total cholesterol (β= −2.33, 95% CI= −4.31, −0.36) and low-density lipoprotein cholesterol levels (β= −1.93, 95% CI= −3.65, −0.21) and a more rapid incremental increase in both markers over time (total cholesterol: β=0.09, 95% CI=0.00, 0.18; low-density lipoprotein cholesterol: β=0.09, 95% CI=0.01, 0.16). No associations were apparent with baseline triglycerides, high-density lipoprotein cholesterol, or changes in either lipid over time. Tests for interaction only found evidence of heterogeneous associations with baseline triglyceride levels, but stratified models hinted at stronger protective associations with baseline levels of total cholesterol and low-density lipoprotein cholesterol among White women. Conclusions Optimism may help diverse individuals establish healthy total cholesterol and low-density lipoprotein cholesterol levels before midlife. Although associations were largely consistent across subgroups, stronger associations among White men and White women highlight a need to study optimism\u27s health impact in diverse samples

Identifying Health Resources and Community Perceptions in the Greater New Haven Area

As required by new laws of the Affordable Care Act, non-profit hospitals are required to produce a Community Health Needs Assessment (CHNA) on a triennial basis in order to receive Medicaid funding, among others. Identification of community health assets is now a requirement by the IRS, in order for the hospital to keep their non-profit status. Community asset mapping (CAM) is an important new component of the community health needs assessment required by the Affordable Care Act for non-profit hospitals. CAM allows these hospitals and the communities they serve to identify key fixtures in their communities that can be leveraged to promote better health and well-being, especially when external resources (e.g. grants) are not available. In partnership with Yale New Haven Health and UnitedWay 2-1-1, we compiled health assets from various towns and communities in the broad Connecticut region. They were classified into six broad areas of need. We conducted interviews with community leaders and residents from the Greater New Haven area, more specifically the West River neighborhood. We hoped to gather insight and perceptions of residents about health assets in their area. Lastly, we generated asset heat maps with GIS to visualize health asset service areas and possibly identify areas of need. Our project sought to expand upon the scope of the mandated CHNA to include community input. Outside of the list of health assets, we went a step further to try to identify possible areas of need based on low coverage by assets on the heat maps.https://elischolar.library.yale.edu/ysph_pbchrr/1028/thumbnail.jp

Association of Optimism and Pessimism with Inflammation and Hemostasis in the Multi-Ethnic Study of Atherosclerosis (MESA)

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/64968/1/Diez Roux_Association of Optimism and Pessemism with Inflammation_2010.pd

Biological Effects of Antiprotons Are Antiprotons a Candidate for Cancer Therapy?

2009 Status Report of AD-4 Experimen

Conjugated linoleic acid isomer concentrations in milk from high- and low-input management dairy systems

BACKGROUND: Different conjugated linoleic acid (CLA) isomers are known to have contrasting physiology or health effects and there is growing evidence that the profile of natural isomers in milk is influenced by the production system. This survey is the first to compare feeding regimes and concentrations of 14 CLA isomers inmilk from three production systems in the UK. RESULTS: Total CLA and seven isomers (including C18 : 2 c9t11 which comprised >80% of total) were significantly higher in milk from both organically certified and non certified low input (LI) systems compared with milk from conventional high input farms. Sampling date also affected concentrations of total CLA and nine isomers; being lowest in March and highest in August. Seasonal differences were greater in milk from LI herds, thought to be due to changes in herbage and/or stage of lactation. Multivariate analysis showed a strong positive relationship between several CLA isomers and increasing levels of fresh forage in the diet. CONCLUSIONS: These results add to the evidence on how management adjustment may improve the profile of CLA isomers in milk fat, although animal or human intervention studies are required to identify the effects of consuming milk with different CLA levels and isomer profiles on human health. (c) 2009 Society of Chemical Industr

Teaching Behaviors That Define Highest Rated Attending Physicians: A Study Of The Resident Perspective

Background: Better understanding teaching behaviors of highly rated clinical teachers could improve training for teaching. We examined teaching behaviors demonstrated by higher rated attending physicians