What helps in self-help? A qualitative exploration of interactions within a borderline personality disorder self-help group

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The Photobook World: Artists' Books and Forgotten Social Objects

International audienceThis volume sets out to challenge and ultimately broaden the category of the 'photobook'. It critiques the popular art-market definition of the photobook as simply a photographer's book, proposing instead to show how books and photos come together as collective cultural productions. Focusing on North American, British and French photobooks from 1920 to the present, the chapters revisit canonical works - by Claudia Andujar and George Love, Mohamed Bourouissa, Walker Evans, Susan Meiselas and Roland Penrose - while also delving into institutional, digital and unrealised projects, illegal practices, DIY communities and the poetic impulse. They throw new light on the way that gendered, racial or colonial assumptions are resisted. Taken as a whole, the volume provides a better understanding of how the meaning of a photobook is collectively produced both inside and outside the art market

Enzyme-replacement therapy from birth delays the development of behavior and learning problems in mucopolysaccharidosis type IIIA mice

Mucopolysaccharidosis type IIIA (MPS IIIA; Sanfilippo syndrome) is a lysosomal storage disorder characterized by severe CNS degeneration, resulting in behavioral abnormalities and loss of learned abilities. Early treatment is vital to prevent long-term clinical pathology in lysosomal storage disorders. We have used naturally occurring MPS IIIA mice to assess the effects of long-term enzyme-replacement therapy initiated either at birth or at 6 wk of age. MPS IIIA and normal control mice received weekly i.v. injections of 1 mg/kg recombinant human sulfamidase until 20 wk of age. Sulfamidase is able to enter the brain until the blood-brain barrier completely closes at 10-14 d of age. MPS IIIA mice that were treated from birth demonstrated normal weight, behavioral characteristics, and ability to learn. MPS IIIA mice that were treated from birth performed significantly better in the Morris water maze than MPS IIIA mice that were treated from 6 wk of age or left untreated. A reduction in storage vacuoles in cells of the CNS in MPS IIIA mice that were treated from birth is consistent with the improvements observed. These data suggest that enzyme that enters the brain in the first few weeks of life, before the blood-brain barrier matures, is able to delay the development of behavior and learning difficulties in MPS IIIA mice