A novel canine model of immune thrombocytopenia: has immune thrombocytopenia (ITP) gone to the dogs?

Canine immune thrombocytopenia (ITP) is analogous to human ITP, with similar platelet counts and heterogeneity in bleeding phenotype among affected individuals. With a goal of ultimately investigating this bleeding heterogeneity, a canine model of antibody-mediated ITP was developed. Infusion of healthy dogs with 2F9, a murine IgG2a monoclonal antibody to the canine platelet glycoprotein GPIIb (a common target of autoantibodies in ITP) resulted in profound, dose-dependent thrombocytopenia. Model dogs developed variable bleeding phenotypes, e.g. petechiae and haematuria, despite similar degrees of thrombocytopenia. 2F9 infusion was not associated with systemic inflammation, consumptive coagulopathy, or impairment of platelet function. Unexpectedly however, evaluation of cytokine profiles led to the identification of platelets as a potential source of serum interleukin-8 (IL8) in dogs. This finding was confirmed in humans with ITP, suggesting that platelet IL8 may be a previously unrecognized modulator of platelet-neutrophil crosstalk. The utility of this model will allow future study of bleeding phenotypic heterogeneity including the role of neutrophils and endothelial cells in ITP

Measurements of the differential production cross sections for a Z boson in association with jets in pp collisions at s\sqrt{s} = 8 TeV

Cross sections for the production of a Z boson in association with jets in proton-proton collisions at a centre-of-mass energy of $\sqrt{s}$=8 TeV are measured using a data sample collected by the CMS experiment at the LHC corresponding to 19.6 inverse femtobarns. Differential cross sections are presented as functions of up to three observables that describe the jet kinematics and the jet activity. Correlations between the azimuthal directions and the rapidities of the jets and the Z boson are studied in detail. The predictions of a number of multileg generators with leading or next-to-leading order accuracy are compared with the measurements. The comparison shows the importance of including multi-parton contributions in the matrix elements and the improvement in the predictions when next-to-leading order terms are included

Search for new physics with the MT2\mathrm{M_{T2}} variable in all-jets final states produced in pp collisions at s=13TeV\mathrm{\sqrt{s} = 13 TeV}

A search for new physics is performed using events that contain one or more jets, no isolated leptons, and a large transverse momentum imbalance, as measured through the MT2 variable, which is an extension of the transverse mass in events with two invisible particles. The results are based on a sample of proton-proton collisions collected at a center-of-mass energy of 13 TeV with the CMS detector at the LHC, and that corresponds to an integrated luminosity of 2.3 inverse femtobarns. The observed event yields in the data are consistent with predictions for the standard model backgrounds. The results are interpreted using simplified models of supersymmetry and are expressed in terms of limits on the masses of potential new colored particles. Assuming that the lightest neutralino is stable and has a mass less than about 500 GeV, gluino masses up to 1550-1750 GeV are excluded at 95% confidence level, depending on the gluino decay mechanism. For the scenario of direct production of squark-antisquark pairs, top squarks with masses up to 800 GeV are excluded, assuming a 100% branching fraction for the decay to a top quark and neutralino. Similarly, bottom squark masses are excluded up to 880 GeV, and masses of light-flavor squarks are excluded up to 600-1260 GeV, depending on the degree of degeneracy of the squark masses

Search for heavy Majorana neutrinos in e±e±\mathrm{ e^\pm e^\pm }+ jets and e±μ±\mathrm{ e^\pm \mu^\pm }+ jets events in proton-proton collisions at s=\sqrt{s} = 8 TeV

A search is performed for heavy Majorana neutrinos (N) decaying into a W boson and a lepton using the CMS detector at the Large Hadron Collider. A signature of two jets and either two same sign electrons or a same sign electron-muon pair is searched for using 19.7 fb$^{-1}$ of data collected during 2012 in proton-proton collisions at a centre-of-mass energy of 8 TeV. The data are found to be consistent with the expected standard model (SM) background and, in the context of a Type-1 seesaw mechanism, upper limits are set on the cross section times branching fraction for production of heavy Majorana neutrinos in the mass range between 40 and 500 GeV. The results are additionally interpreted as limits on the mixing between the heavy Majorana neutrinos and the SM neutrinos. In the mass range considered, the upper limits range between 0.00015-0.72 for $| \mathrm{V_{eN}} |^2$ and 6.6 $\times$ 10$^{-5}$-0.47 for $| \mathrm{V_{eN}} \mathrm{V^{*}_{\mu N}} |^2 / ( | \mathrm{V_{eN}} |^2 + | \mathrm{V_{\mu N}} |^2 )$, where $\mathrm{V_{\ell N}}$ is the mixing element describing the mixing of the heavy neutrino with the SM neutrino of flavour $\ell$. These limits are the most restrictive direct limits for heavy Majorana neutrino masses above 200 GeV.A search is performed for heavy Majorana neutrinos (N) decaying into a W boson and a lepton using the CMS detector at the Large Hadron Collider. A signature of two jets and either two same sign electrons or a same sign electron-muon pair is searched for using 19.7 fb$^{−1}$ of data collected during 2012 in proton-proton collisions at a centre-of-mass energy of 8 TeV. The data are found to be consistent with the expected standard model (SM) background and, in the context of a Type-1 seesaw mechanism, upper limits are set on the cross section times branching fraction for production of heavy Majorana neutrinos in the mass range between 40 and 500 GeV. The results are additionally interpreted as limits on the mixing between the heavy Majorana neutrinos and the SM neutrinos. In the mass range considered, the upper limits range between 0.00015–0.72 for |V$_{eN}$|$^{2}$ and 6.6 × 10$^{−5}$−0.47 for |V$_{eN}$ V$_{μN}^{∗}$ |$^{2}$/(|V$_{eN}$|$^{2}$ + |V$_{μN}$|$^{2}$), where V$_{ℓN}$ is the mixing element describing the mixing of the heavy neutrino with the SM neutrino of flavour ℓ. These limits are the most restrictive direct limits for heavy Majorana neutrino masses above 200 GeV.A search is performed for heavy Majorana neutrinos (N) decaying into a W boson and a lepton using the CMS detector at the Large Hadron Collider. A signature of two jets and either two same sign electrons or a same sign electron-muon pair is searched for using 19.7 inverse femtobarns of data collected during 2012 in proton-proton collisions at a centre-of-mass energy of 8 TeV. The data are found to be consistent with the expected standard model (SM) background and, in the context of a Type-1 seesaw mechanism, upper limits are set on the cross section times branching fraction for production of heavy Majorana neutrinos in the mass range between 40 and 500 GeV. The results are additionally interpreted as limits on the mixing between the heavy Majorana neutrinos and the SM neutrinos. In the mass range considered, the upper limits range between 0.00015 - 0.72 for |V[eN]|^2 and 6.6E-5 - 0.47 for |V[eN] V*[muN]|^2 / ( |V[eN]|^2 + |V[muN]|^2 ), where V[lN] is the mixing element describing the mixing of the heavy neutrino with the SM neutrino of flavour l. These limits are the most restrictive direct limits for heavy Majorana neutrino masses above 200 GeV

Studies of inclusive four-jet production with two bb-tagged jets in proton-proton collisions at 7 TeV

Measurements are presented of the cross section for the production of at least four jets, of which at least two originate from b quarks, in proton-proton collisions. Data collected with the CMS detector at the LHC at a center-of-mass energy of 7 TeV are used, corresponding to an integrated luminosity of 3 pb$^{-1}$. The cross section is measured as a function of the jet transverse momentum for p$_T$>20 GeV, and of the jet pseudorapidity for |η|<2.4 (b jets), 4.7 (untagged jets). The correlations in azimuthal angle and pT between the jets are also studied. The inclusive cross section is measured to be σ(pp→2b+2j+X)=69±3(stat)±24(syst) nb. The η and p$_T$ distributions of the four jets and the correlations between them are well reproduced by event generators that combine perturbative QCD calculations at next-to-leading-order accuracy with contributions from parton showers and multiparton interactions