2 research outputs found
Crystallized and fluid intelligence are predicted by microstructure of specific white-matter tracts
Studies of the neural basis of intelligence have focused on comparing brain imaging variables with global scales instead of the cognitive domains integrating these scales or quotients. Here, the relation between mean tract‐based fractional anisotropy (mTBFA) and intelligence indices was explored. Deterministic tractography was performed using a regions of interest approach for 10 white‐matter fascicles along which the mTBFA was calculated. The study sample included 83 healthy individuals from the second wave of the Cuban Human Brain Mapping Project, whose WAIS‐III intelligence quotients and indices were obtained. Inspired by the “Watershed model” of intelligence, we employed a regularized hierarchical Multiple Indicator, Multiple Causes model (MIMIC), to assess the association of mTBFA with intelligence scores, as mediated by latent variables summarizing the indices. Regularized MIMIC, used due to the limited sample size, selected relevant mTBFA by means of an elastic net penalty and achieved good fits to the data. Two latent variables were necessary to describe the indices: Fluid intelligence (Perceptual Organization and Processing Speed indices) and Crystallized Intelligence (Verbal Comprehension and Working Memory indices). Regularized MIMIC revealed effects of the forceps minor tract on crystallized intelligence and of the superior longitudinal fasciculus on fluid intelligence. The model also detected the significant effect of age on both latent variables
Semi-analytic Local Linearization Integration of high dimensional Neural Mass Models with distributed delays
Neuroscience has shown great progress in recent years. Several of the
theoretical bases have arisen from the examination of dynamic systems, using
Neural Mass Models (NMMs). Due to the largescale brain dynamics of NMMs and the
difficulty of studying nonlinear systems, the local linearization approach to
discretize the state equation was used via an algebraic formulation, as it
intervenes favorably in the speed and efficiency of numerical integration. To
study the spacetime organization of the brain and generate more complex
dynamics, three structural levels (cortical unit, population and system) were
defined and assumed, in which the new assumed representation for conduction
delays and new ways of connecting were defined. This is a new time-delay NMM,
which can simulate several types of EEG activities since kinetics information
was considered at three levels of complexity. Results obtained in this analysis
provide additional theoretical foundations and indicate specific
characteristics for understanding neurodynamic.Comment: 12 pages, 6 figures, 2 table