44 research outputs found
Tissue Engineering of Articular Cartilage under the Influence of Collagen I/III Membranes and Low Oxygen Tension
The effects of multiple land use policies upon the use and productivity of farmland Interim report
SIGLELD:f81/4056. / BLDSC - British Library Document Supply CentreGBUnited Kingdo
Treatment of Infected Pseudarthrosis of the Inferior Limb with Low-Frequency Pulsing Electromagnetic Fields: Report of 16 Cases
Effect of Oxygen Tension on Adult Articular Chondrocytes in Microcarrier Bioreactor Culture
Interactions Between Weak Electromagnetic Fields And Biosystems: A Summary of Nine Years of Research
New Era of Cell-Based Orthopedic Therapies
There has long been a described relationship between mesenchymal stem cells (MSCs) and blood vessels in aspects of bone and other skeletal tissues with regard to their embryonic formation and their adult repair and regeneration dynamics. The use of exogenously added MSCs to supplement the naturally available progenitor cell stock has been a standard practice in several orthopedic surgeries by adding bone marrow to the repair constructs. This, coupled with the well-established need for vasculature to orient and drive bone formation, firmly established the functional relationship between MSCs, osteoprogenitors, and blood vessels. It is now apparent that MSCs are pericytes (cells that surround blood vessels) throughout the body. In addition, MSCs can function to secrete bioactive factors that are immunomodulatory, thus allowing allogeneic MSCs to be infused into patients requiring clinically relevant treatments. Such infused MSCs trophically establish microenvironments that support the regeneration of the injured tissue. These new functions usher in a new era of cell-based therapies