1,498 research outputs found
Seeing the Old Lady: A New Perspective on the Age Old Problems of Discrimination, Inequality, and Subordination
In recent years, legal scholars have used insights from cognitive and social psychology to explain that, despite significant gains, discrimination persists in America. Specifically, such scholars argue that our current antidiscrimination legal system, aimed at overt, conscious, and intentional conduct is not an effective tool for combating current forms of discrimination that are often subtle, unconscious, and unintentional. This article builds on that work by illustrating that, while insightful, the perspective from which these scholars approach the problem of discrimination is really no different from that which informs the current antidiscrimination system they seek to change. Accordingly, this article will explain how the perspective of these scholars is the same as that informing the current system. Second, this article will put forth an alternative perspective and then demonstrate how the new point of view advocated for opens up new possibilities with respect to how we might eradicate discrimination from American society
Narrowing the Accountability Gap: Toward a New Foreign Investor Accountability Mechanism
An ever-increasing number of standards, guidelines, principles, norms, and best practices have been adopted to address the environmental and social impacts of multinational enterprises (MNEs). This increase in standards and norms corresponds to a rise in MNE sensitivity to the environmental and social impacts that their activities have on local communities in developing countries. These standards and norms are considered voluntary by definition because they are typically not state-sponsored or the product of public regulation. They fill a normative gap located between the state-centered focus of international law and the often inadequate or unenforced standards of the developing country hosts for MNE activities, but relatively little attention has been paid to mechanisms for ensuring compliance with them.
This article proposes a new Foreign Investor Accountability Mechanism (“the Mechanism”). The Mechanism will narrow the accountability gap by providing communities affected by foreign investment projects with an avenue for voicing their concerns and for holding MNEs accountable both to local and national laws that may apply. The Mechanism will also allow affected communities to enforce the various promises that MNEs make during project design, approval, and preconstruction phases, or to gain financing or the ‘social license to operate.’ These promises may include: commitments to follow international, industry-wide, or sectoral standards and norms; commitments made as part of corporate-wide social and environmental policies; and project-specific commitments made to secure host government approval or financing from financial institutions, such as the International Finance Corporation, export credit agencies, or private commercial banks
Narrowing the Accountability Gap: Toward a New Foreign Investor Accountability Mechanism
An ever-increasing number of standards, guidelines, principles, norms, and best practices have been adopted to address the environmental and social impacts of multinational enterprises (MNEs). This increase in standards and norms corresponds to a rise in MNE sensitivity to the environmental and social impacts that their activities have on local communities in developing countries. These standards and norms are considered voluntary by definition because they are typically not state-sponsored or the product of public regulation. They fill a normative gap located between the state-centered focus of international law and the often inadequate or unenforced standards of the developing country hosts for MNE activities, but relatively little attention has been paid to mechanisms for ensuring compliance with them.
This article proposes a new Foreign Investor Accountability Mechanism (“the Mechanism”). The Mechanism will narrow the accountability gap by providing communities affected by foreign investment projects with an avenue for voicing their concerns and for holding MNEs accountable both to local and national laws that may apply. The Mechanism will also allow affected communities to enforce the various promises that MNEs make during project design, approval, and preconstruction phases, or to gain financing or the ‘social license to operate.’ These promises may include: commitments to follow international, industry-wide, or sectoral standards and norms; commitments made as part of corporate-wide social and environmental policies; and project-specific commitments made to secure host government approval or financing from financial institutions, such as the International Finance Corporation, export credit agencies, or private commercial banks
Correlation Between Student Collaboration Network Centrality and Academic Performance
We compute nodal centrality measures on the collaboration networks of
students enrolled in three upper-division physics courses, usually taken
sequentially, at the Colorado School of Mines. These are complex networks in
which links between students indicate assistance with homework. The courses
included in the study are intermediate Classical Mechanics, introductory
Quantum Mechanics, and intermediate Electromagnetism. By correlating these
nodal centrality measures with students' scores on homework and exams, we find
four centrality measures that correlate significantly with students' homework
scores in all three courses: in-strength, out-strength, closeness centrality,
and harmonic centrality. These correlations suggest that students who not only
collaborate often, but also collaborate significantly with many different
people tend to achieve higher grades. Centrality measures between simultaneous
collaboration networks (analytical vs. numerical homework collaboration)
composed of the same students also correlate with each other, suggesting that
students' collaboration strategies remain relatively stable when presented with
homework assignments targeting different skills. Additionally, we correlate
centrality measures between collaboration networks from different courses and
find that the four centrality measures with the strongest relationship to
students' homework scores are also the most stable measures across networks
involving different courses. Correlations of centrality measures with exam
scores were generally smaller than the correlations with homework scores,
though this finding varied across courses.Comment: 10 pages, 4 figures, submitted to Phys. Rev. PE
Automatic correction of hand pointing in stereoscopic depth
In order to examine whether stereoscopic depth information could drive fast automatic correction of hand pointing, an experiment was designed in a 3D visual environment in which participants were asked to point to a target at different stereoscopic depths as quickly and accurately as possible within a limited time window (≤300 ms). The experiment consisted of two tasks: "depthGO" in which participants were asked to point to the new target position if the target jumped, and "depthSTOP" in which participants were instructed to abort their ongoing movements after the target jumped. The depth jump was designed to occur in 20% of the trials in both tasks. Results showed that fast automatic correction of hand movements could be driven by stereoscopic depth to occur in as early as 190 ms.This work was supported by the Grants from the National Natural Science Foundation of China (60970062 and 61173116) and the Doctoral Fund of Ministry of Education of China (20110072110014)
The initiator methionine tRNA drives secretion of type II collagen from stromal fibroblasts to promote tumor growth and angiogenesis
Summary:
Expression of the initiator methionine tRNA (tRNAi
Met)
is deregulated in cancer. Despite this fact, it is not
currently known how tRNAi
Met expression levels influence
tumor progression. We have found that tRNAi
Met
expression is increased in carcinoma-associated
fibroblasts, implicating deregulated expression of
tRNAi
Met in the tumor stroma as a possible contributor
to tumor progression. To investigate how elevated
stromal tRNAi
Met contributes to tumor progression,
we generated a mouse expressing additional copies
of the tRNAi
Met gene (2+tRNAi
Met mouse). Growth
and vascularization of subcutaneous tumor allografts
was enhanced in 2+tRNAi
Met mice compared with
wild-type littermate controls. Extracellular matrix
(ECM) deposited by fibroblasts from 2+tRNAi
Met
mice supported enhanced endothelial cell and fibroblast
migration. SILAC mass spectrometry indicated
that elevated expression of tRNAi
Met significantly
increased synthesis and secretion of certain types of
collagen, in particular type II collagen. Suppression
of type II collagen opposed the ability of tRNAi
Metoverexpressing
fibroblasts to deposit pro-migratory
ECM. We used the prolyl hydroxylase inhibitor ethyl-
3,4-dihydroxybenzoate (DHB) to determine whether
collagen synthesis contributes to the tRNAi
Met-driven
pro-tumorigenic stroma in vivo. DHB had no effect
on the growth of syngeneic allografts in wild-type
mice but opposed the ability of 2+tRNAi
Met mice to
support increased angiogenesis and tumor growth.
Finally, collagen II expression predicts poor prognosis
in high-grade serous ovarian carcinoma. Taken
together, these data indicate that increased tRNAi
Met
levels contribute to tumor progression by enhancing
the ability of stromal fibroblasts to synthesize and
secrete a type II collagen-rich ECM that supports
endothelial cell migration and angiogenesis
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