What are They Saying about the Grace of Christ

Reviewed Book: McDermott, Brian O. What are They Saying about the Grace of Christ. [S.l.]: Paulist Press, 1984

Solution structure of human MBD1 CXXC1

No abstract available

Protein-nucleic acids interactions: new ways of connecting structure, dynamics and function

No abstract available

Calisia Kelley v. Brian O\\u27Malley

USDC for the Western District of Pennsylvani

Alumni

Poverty warrior Donald Anderson; environmental litigator Brian O\u27Neill; class notes and deaths

UD Law Students Argue Successfully for Change in U.S. Military Law

News release announces that the legal work of Brian O\u27Connell and Brent Curtis has changed U.S. military law

The cAMP sensors, EPAC1 and EPAC2, display distinct subcellular distributions despite sharing a common nuclear pore localisation signal

We have identified a conserved nuclear pore localisation signal (NPLS; amino acids 764–838 of EPAC1) in the catalytic domains of the cAMP-sensors, EPAC1 and EPAC2A. Consequently, EPAC1 is mainly localised to the nuclear pore complex in HEK293T cells where it becomes activated following stimulation with cAMP. In contrast, structural models indicate that the cAMP-binding domain of EPAC2A (CNBD1) blocks access to the conserved NPLS in EPAC2A, reducing its ability to interact with nuclear binding sites. Consequently, a naturally occurring EPAC2 isoform, EPAC2B, which lacks CNBD1 is enriched in nuclear fractions, similar to EPAC1. Structural differences in EPAC isoforms may therefore determine their intracellular location and their response to elevations in intracellular cAMP

State of the University Address, 2022

Old Dominion University President Brian O. Hemphill\u27s first State of the University Address presented September 2, 2022 at Chartway Arena