Dysregulation of specialized delay/interference-dependent working memory following loss of dysbindin-1A in schizophrenia-related phenotypes

Dysbindin-1, a protein that regulates aspects of early and late brain development, has been implicated in the pathobiology of schizophrenia. As the functional roles of the three major isoforms of dysbindin-1, (A, B, and C) remain unknown, we generated a novel mutant mouse, dys-1A -/-, with selective loss of dysbindin-1A and investigated schizophrenia-related phenotypes in both males and females. Loss of dysbindin-1A resulted in heightened initial exploration and disruption in subsequent habituation to a novel environment, together with heightened anxiety-related behavior in a stressful environment. Loss of dysbindin-1A was not associated with disruption of either long-term (olfactory) memory or spontaneous alternation behavior. However, dys-1A -/-showed enhancement in delay-dependent working memory under high levels of interference relative to controls, ie, impairment in sensitivity to the disruptive effect of such interference. These findings in dys-1A -/-provide the first evidence for differential functional roles for dysbindin-1A vs dysbindin-1C isoforms among phenotypes relevant to the pathobiology of schizophrenia. Future studies should investigate putative sex differences in these phenotypic effects

Kinetics of Reductive Dechlorination of Trichloroethane (TCA) by Anaerobic Biofilms

HWRIC project number 90-07

Chemotactic behavioral investigations with tethered cells

Thesis (B.S.) in Biochemistry--University of Illinois at Urbana-Champaign, 1980.Bibliography: leaf [21].Microfiche of typescript. [Urbana, Ill.] : Photographic Services, University of Illinois, U of I Library, [1983]. 1 microfiche (28 frames) : negative ; 11 x 15 cm

Assessment of Sediment Toxicity During Anaerobic Biodegradation of Vegetable Oil Using Microtox\u3csup\u3e®\u3c/sup\u3e and \u3ci\u3eHyalella azteca\u3c/i\u3e Bioassays

The potential ecological impacts of anaerobic degradation of vegetable oil on freshwater sediments were investigated. Sediment toxicity was evaluated using two regulatory biotests: the Microtox® Solid Phase Test and an amphipod (Hyalella azteca) bioassay. The results of the Microtox test showed that the toxicity of the vegetable-oil-contaminated sediments (about 17–33 g oil/kg dry sediments) increased after 2 weeks incubation and then decreased to near background levels after incubation for 8 weeks under anaerobic conditions. The amphipod toxicity bioassay showed that the toxicity of fresh contaminated sediments decreased over time and returned to background levels within 8 weeks. These results suggest that the impact of vegetable oils on organisms within sediments may be limited. To account for the significance of environmental conditions, additional studies over a wide range of incubation conditions (e.g., temperature, nutrient concentration) and other test organisms at various trophic levels are recommended for both acute and chronic toxicity assessment

Production of Bioenergy and Biochemicals from Industrial and Agricultural Wastewater

The Building of a Sustainable Society Will Require Reduction of Dependency on Fossil Fuels and Lowering of the Amount of Pollution that is Generated. Wastewater Treatment is an Area in Which These Two Goals Can Be Addressed Simultaneously. as a Result, There Has Been a Paradigm Shift Recently, from Disposing of Waste to using It. There Are Several Biological Processing Strategies that Produce Bioenergy or Biochemicals While Treating Industrial and Agricultural Wastewater, Including Methanogenic Anaerobic Digestion, Biological Hydrogen Production, Microbial Fuel Cells and Fermentation for Production of Valuable Products. However, There Are Also Scientific and Technical Barriers to the Implementation of These Strategies

Deletion and Gene Expression Analyses Define the Paxilline Biosynthetic Gene Cluster in Penicillium paxilli

toxin

Measuring internal market orientation

Internal marketing has been discussed in the management and academic literature for over three decades, yet it remains ill defined and poorly operationalized. This paper responds to calls for research to develop a single clear understanding of the construct, for the development of a suitable instrument to measure it, and for empirical evidence of its impact. Existing, divergent conceptualization of internal marketing are explored, and a new, multidimensional construct, describing the managerial behaviors associated with internal marketing is developed, and termed internal market orientation (IMO). IMO represents the adaptation of market orientation to the context of employer-employee exchanges in the internal market. The paper describes the development of a valid and reliable measure of IMO in a retail services context. Five dimensions of IMO are identified and confirmed. These are 1) formal written information generation, 2) formal face-to-face information generation, 3) informal information generation, 4) communication and dissemination of information, and 5) responding to this internal market information. The impact of IMO on important organizational factors is also explored. Results indicate positive consequences for customer satisfaction, relative competitive position, staff attitudes, staff retention and staff compliance