Shape-induced force fields in optical trapping

Advances in optical tweezers, coupled with the proliferation of two-photon polymerization systems, mean that it is now becoming routine to fabricate and trap non-spherical particles. The shaping of both light beams and particles allows fine control over the flow of momentum from the optical to mechanical regimes. However, understanding and predicting the behaviour of such systems is highly complex in comparison with the traditional optically trapped microsphere. In this Article, we present a conceptually new and simple approach based on the nature of the optical force density. We illustrate the method through the design and fabrication of a shaped particle capable of acting as a passive force clamp, and we demonstrate its use as an optically trapped probe for imaging surface topography. Further applications of the design rules highlighted here may lead to new sensors for probing biomolecule mechanics, as well as to the development of optically actuated micromachines

Holographic Glueballs and Infrared Wall Driven by Dilaton

We study glueballs in the holographic gauge theories, supersymmetric and non-super symmetric cases, which are given by the type IIB superstring solutions with non-trivial dilaton. In both cases, the dilaton reflects the condensate of the gauge field strength, $$, which is responsible to the linear confining potential between the quark and anti-quark. Then we could see the meson spectra. On the other hand, the glueball spectra are not found in the supersymmetric case. We need a sharp wall, which corresponds to an infrared cutoff, in order to obtain the glueballs. In the non-supersymmetric case, the quantized glueballs are actually observed due to the existence of such a wall driven by the dilaton. The strings and D-branes introduced as building blocks of hadrons are pushed out by this wall, and we could see the Regge behavior of the higher spin meson and glueball states. We find that the slope of the glueball trajectory is half of the flavor meson's one. As for the low spin glueballs, they are studied by solving the fluctuations of the bulk fields, and their discrete spectra are shown.Comment: 35 pages, 6 figure

Whole Grain Products, Fish and Bilberries Alter Glucose and Lipid Metabolism in a Randomized, Controlled Trial: The Sysdimet Study

Due to the growing prevalence of type 2 diabetes, new dietary solutions are needed to help improve glucose and lipid metabolism in persons at high risk of developing the disease. Herein we investigated the effects of low-insulin-response grain products, fatty fish, and berries on glucose metabolism and plasma lipidomic profiles in persons with impaired glucose metabolism.Altogether 106 men and women with impaired glucose metabolism and with at least two other features of the metabolic syndrome were included in a 12-week parallel dietary intervention. The participants were randomized into three diet intervention groups: (1) whole grain and low postprandial insulin response grain products, fatty fish three times a week, and bilberries three portions per day (HealthyDiet group), (2) Whole grain enriched diet (WGED) group, which includes principally the same grain products as group (1), but with no change in fish or berry consumption, and (3) refined wheat breads (Control). Oral glucose tolerance, plasma fatty acids and lipidomic profiles were measured before and after the intervention. Self-reported compliance with the diets was good and the body weight remained constant. Within the HealthyDiet group two hour glucose concentration and area-under-the-curve for glucose decreased and plasma proportion of (n-3) long-chain PUFAs increased (False Discovery Rate p-values <0.05). Increases in eicosapentaenoic acid and docosahexaenoic acid associated curvilinearly with the improved insulin secretion and glucose disposal. Among the 364 characterized lipids, 25 changed significantly in the HealthyDiet group, including multiple triglycerides incorporating the long chain (n-3) PUFA.The results suggest that the diet rich in whole grain and low insulin response grain products, bilberries, and fatty fish improve glucose metabolism and alter the lipidomic profile. Therefore, such a diet may have a beneficial effect in the efforts to prevent type 2 diabetes in high risk persons.ClinicalTrials.gov NCT00573781

Late Quaternary palaeoecology of Ballona Lagoon in southern California

Los ambientes costeros del Cuaternario, incluyendo a los estuarios, son de gran importancia para los arqueólogos, geólogos y paleoecólogos debido a los dramáticos cambios en la geografía costera que afectan seriamente la adaptación humana y el uso de los recursos. Los estuarios son afectados principalmente por agentes climáticos y geológicos tales como tectonismo, subsidencia y cambios en el nivel del mar tanto isostáticos como eustáticos. En el presente estudio de la Laguna de Ballona, localizada en el área metropolitana de Los |00C3|?ngeles, California, documentamos la reconstrucción ambiental del estuario que la formó. Los estuarios se caracterizan por una rica biota que incluye una diversidad de peces, ostrácodos, moluscos, foraminíferos, organismos silíceos (diatomeas y silicoflagelados), así como residuos de vegetación representada por los palinomorfos. Analizamos los ostrácodos y palinomorfos en combinación con análisis estratigráficos y geocronométricos del área de estudio. El objetivo central del estudio fue delinear los bordes de la laguna y documentar su migración en el tiempo. La identificación de los bordes de la laguna fue importante para determinar la forma y razones de cambio de uso del área a través del tiempo por los pobladores prehistóricos Quaternary coastal environments, including estuaries, are significant to archaeologists, geologists, and palaeoecologists because dramatic changes in geographic settings have strongly affected human land use and adaptation. Estuaries are mainly affected by climate and geologic agents like tectonism, subsidence, and isostatic and eustatic sea level changes. This study of Ballona Lagoon, California, located in the Los Angeles metropolitan area, presents the paleoenvironmental reconstruction of an estuary. Estuaries are characterized by diverse assemblages of fishes, ostracodes, molluscs, foraminifers, siliceous organisms (diatoms and silicoflagellates), and traces of vegetation represented by palynomorphs. Ostracode and pollen analyses were conducted in combination with stratigraphic and geochronometric analyses. A central goal of this study was to delineate the lagoon edge and to document how it migrated through time. The location of the lagoon edge was important in determining how and why prehistoric land-use patterns shifted through time