Outsourcing VDC Workflows

In an increasingly demanding world for infrastructure, technological methods have been found to assist construction project\u27s. As innovative construction methods are constantly increasing, so is the demand for technological needs within the architecture, engineering, and construction (AEC) industry. To ensure technological adoption, many countries have started to mandate higher levels of building information modeling (BIM) documentation beyond the 2D construction documents traditionally required throughout construction review and permitting. Some companies have capitalized on this change to the extent of making BIM their primary business. These companies focus solely on virtual design and construction (VDC) and determine whether clients lacking this specialty should outsource their technological needs or invest in their own VDC department. Through attitudinal research, three interviews were conducted to understand contractors’ response to the implementation of a platform that links contractors to freelance modelers specializing in VDC. This research aims to better understand if the use of a third-party platform is effective for contractors that are unwilling to adapt to mandated BIM requirements

Glial Tumor Necrosis Factor Alpha (TNFα) Generates Metaplastic Inhibition of Spinal Learning

Injury-induced overexpression of tumor necrosis factor alpha (TNFα) in the spinal cord can induce chronic neuroinflammation and excitotoxicity that ultimately undermines functional recovery. Here we investigate how TNFα might also act to upset spinal function by modulating spinal plasticity. Using a model of instrumental learning in the injured spinal cord, we have previously shown that peripheral intermittent stimulation can produce a plastic change in spinal plasticity (metaplasticity), resulting in the prolonged inhibition of spinal learning. We hypothesized that spinal metaplasticity may be mediated by TNFα. We found that intermittent stimulation increased protein levels in the spinal cord. Using intrathecal pharmacological manipulations, we showed TNFα to be both necessary and sufficient for the long-term inhibition of a spinal instrumental learning task. These effects were found to be dependent on glial production of TNFα and involved downstream alterations in calcium-permeable AMPA receptors. These findings suggest a crucial role for glial TNFα in undermining spinal learning, and demonstrate the therapeutic potential of inhibiting TNFα activity to rescue and restore adaptive spinal plasticity to the injured spinal cord. TNFα modulation represents a novel therapeutic target for improving rehabilitation after spinal cord injury

The James Webb Space Telescope Mission

Twenty-six years ago a small committee report, building on earlier studies, expounded a compelling and poetic vision for the future of astronomy, calling for an infrared-optimized space telescope with an aperture of at least $4m$. With the support of their governments in the US, Europe, and Canada, 20,000 people realized that vision as the $6.5m$ James Webb Space Telescope. A generation of astronomers will celebrate their accomplishments for the life of the mission, potentially as long as 20 years, and beyond. This report and the scientific discoveries that follow are extended thank-you notes to the 20,000 team members. The telescope is working perfectly, with much better image quality than expected. In this and accompanying papers, we give a brief history, describe the observatory, outline its objectives and current observing program, and discuss the inventions and people who made it possible. We cite detailed reports on the design and the measured performance on orbit.Comment: Accepted by PASP for the special issue on The James Webb Space Telescope Overview, 29 pages, 4 figure

Spatial competition with endogenous location choices: An application to discount retailing

Entry, Discrete games, Location choice, Retail competition, Discount stores, L1, L2, L81, R3,