Changes in English vocal church music from the beginning of the Commonwealth (1649) through the Restoration (1688).

Thesis (M.M.)--Boston Universit

Cooperative Conversions, Failures and Restructurings: An Overview

The cases assembled in this special issue provide a rich setting for an examination of a number of cooperative conversion and restructurings that have occurred over the last 10 years. The cases also provide some lessons on the larger cooperative problems and questions in which cooperative researchers have been interested. The cases suggest that some of the conversions and restructurings are due to what can simply be called poor management, something that is not unique to co-ops, but is in fact common to all business enterprises regardless of their structure. At the same time, the cases also point out that common structural problems associated with cooperatives – such as lack of capital, property right problems and portfolio problems – do have an impact on the structure chosen by cooperatives and their members. Finally, a number of case-study authors point to increasing capital requirements in industrialized agriculture as a significant challenge for cooperatives seeking to integrate along the supply chain.Agribusiness,

Does Increasing Flow to a High Flow Nasal Cannula Affect Mean Airway Pressure in an In Vitro Model?

DOES INCREASING FLOW TO A HIGH FLOW NASAL CANNULA AFFECT MEAN AIRWAY PRESSURE IN AN IN VITRO MODEL? Introduction: High-flow nasal cannulas (HFNC) have become popular with many institutions for administration of oxygen (O2). HFNCs are also being used in pediatric and neonatal populations for administration of continuous positive airway pressure (CPAP) as a treatment for respiratory distress. Adult patients are being treated with HFNCs in a effort to provide a high percentage of O2 and correct hypoxemia and other related conditions. The purpose of this study was to examine the effect of increasing flow via a HFNC to an in vitro model to examine the effect of flow on mean airway pressure (MPAW). Method: An in vitro model to simulate non-labored and labored spontaneous breathing was developed using a Michigan Instrument Laboratory Test and Training Lung (MIL TTL) driven by a Hamilton Galileo ventilator to produce a negatively based, inspired tidal volume. Flow was introduced to the MIL TTL via a 41 French double lumen endotracheal tube. Airway pressure measurements were observed via a pressure monitoring port placed between the MIL TTL and the endotracheal tube and connected to the auxiliary pressure monitoring port located on the front of the Galileo ventilator. A Vapotherm 2000i with adult transfer chamber and adult cannula, a Fisher Paykel Optiflow, and a generic HFNC consisting of a concha column and a Salter labs high-flow cannula were tested at 20, 30, and 40LPM flowrates. Data was recorded using two respiratory rates (12 and 24) and two peak flowrates (35 and 65LPM) to simulate non-labored and labored breathing. All other parameters were unchanged and the I:E ratio was consistent. Data Analysis: SPSS 16.0 for Windows was used to analyze all data for this study. Descriptive statistics, one-way analysis of variance (ANOVA), and post hoc Bonferroni was used for this study. A p value less than 0.05 were considered significant. Results: Average MPAW for all devices were increased at all three flowrates. MPAW was highest at 40LPM flow producing 3.1cmH2O averaged for all HFNCs and both respiratory patterns. The difference in MPAW produced by the three HFNCs were also significant with at p=0.000 at all flow rates. Post hoc Bonferroni adjusted probabilities further showed all device comparisons significant except for Vapotherm-Vapotherm Labored at 30 and 40 LPM flow rates and Vapotherm-Generic Labored at 20 LPM at p\u3c0.05. These three comparisons were at p\u3e0.05 and were statistically equal. The generic HFNC produced the highest MPAW (3.5cmH2O). Conclusion: Increased flow via a HFNC does increase MPAW. The Vapotherm, Optiflow, and generic HFNC did not produce the same level of MPAW in this study

Review: Marine natural products

This review covers the literature published in 2003 for marine natural products, with 619 citations (413 for the period January to December 2003) referring to compounds isolated from marine microorganisms and phytoplankton, green algae, brown algae, red algae, sponges, coelenterates, bryozoans, molluscs, tunicates and echinoderms. The emphasis is on new compounds (656 for 2003), together with their relevant biological activities, source organisms and country of origin. Biosynthetic studies or syntheses that lead to the revision of structures or stereochemistries have been included (78), including any first total syntheses of a marine natural product

Historic landmarks in clinical transplantation: Conclusions from the consensus conference at the University of California, Los Angeles

The transplantation of organs, cells, and tissues has burgeoned during the last quarter century, with the development of multiple new specialty fields. However, the basic principles that made this possible were established over a three-decade period, beginning during World War II and ending in 1974. At the historical consensus conference held at UCLA in March 1999, 11 early workers in the basic science or clinical practice of transplantation (or both) reached agreement on the most significant contribution of this era that ultimately made transplantation the robust clinical discipline it is today. These discoveries and achievements are summarized here is six tables and annotated with references

A Case–Control Analysis of Exposure to Traffic and Acute Myocardial Infarction

BACKGROUND: Long-term exposure to particulate air pollution has been associated with an increased risk of dying from cardiopulmonary and ischemic heart disease, yet few studies have evaluated cardiovascular end points other than mortality. We investigated the relationship between long-term exposure to traffic and occurrence of acute myocardial infarction (AMI) in a case–control study. METHODS: A total of 5,049 confirmed cases of AMI were identified between 1995 and 2003 as part of the Worcester Heart Attack Study, a community-wide study examining changes over time in the incidence of AMI among greater Worcester, Massachusetts, residents. Population controls were selected from Massachusetts resident lists. We used cumulative traffic within 100 m of subjects’ residence and distance from major roadway as proxies for exposure to traffic-related air pollution. We estimated the relationship between exposure to traffic and occurrence of AMI using logistic regression, and we adjusted for the following potential confounders: age, sex, section of the study area, point sources emissions of particulate matter with aerodynamic diameter < 2.5 μm, area socioeconomic characteristics, and percentage of open space. RESULTS: An increase in cumulative traffic near the home was associated with a 4% increase in the odds of AMI per interquartile range [95% confidence interval (CI), 2–7%], whereas living near a major roadway was associated with a 5% increase in the odds of AMI per kilometer (95% CI, 3–6%). CONCLUSIONS: hese results provide support for an association between long-term exposure to traffic and the risk of AMI

The infrared imaging spectrograph (IRIS) for TMT: on-instrument wavefront sensors and NFIRAOS interface

The InfraRed Imaging Spectrograph (IRIS) is a first light client science instrument for the TMT observatory that operates as a client of the NFIRAOS facility multi-conjugate adaptive optics system. This paper reports on the concept study and baseline concept design of the On-Instrument WaveFront Sensors (OIWFS) and NFIRAOS interface subsystems of the IRIS science instrument, a collaborative effort by NRC-HIA, Caltech, and TMT AO and Instrument teams. This includes work on system engineering, structural and thermal design, sky coverage modeling, patrol geometry, probe optics and mechanics design, camera design, and controls design.Comment: 17 pages, 12 figures, SPIE7735-28

Elucidating the Polymorphism of Xanthone: A Crystallization and Characterization Study

The aim of this work is to shed light on the polymorphism of xanthones, a class of oxygenated molecules well known for their bioactivity, including antioxidant, anticancer, and anti-inflammatory effects. Understanding the polymorphism of xanthones can enable the design of novel solid products for pharmaceutical, nutraceutical, and agrochemical applications. Prior to this work, two entries accounting for different space groups were deposited for 9-xanthone in the Cambridge Structure Database (CSD): an orthorhombic P2(1)2(1)2(1) and a monoclinic P2(1) structure solved at room and low temperatures, respectively. However, the very high similarity between these two structures and the lack of clear differences in their physical properties (e.g., thermal behavior) suggested the possibility of the existence of only one crystal structure. In fact, the differences shown in the literature data might be related to the chosen operating parameters, as well as the instrumental resolution of the single-crystal X-ray diffraction experiments. In the work presented here, the ambiguity in the polymorphism of xanthone is investigated using thermal analysis, powder and synchrotron single-crystal XRD, and optical microscopy. Additionally, a workflow for the correct identification of twinned crystal structures, which can be applied to other polymorphic systems, is presented. Such workflow combines the collection of a large data set of high-resolution diffraction patterns using synchrotron radiation with the use of principal component analysis, a dimensionality reduction technique, for a quick and effective identification of phase transitions happening during the data collection. Crystallization experiments were designed to promote the formation of different crystal structures of xanthone that were recrystallized based on past literature and beyond

Long-term Exposure to PM2.5PM_{2.5} and Incidence of Acute Myocardial Infarction

Background: A number of studies have shown associations between chronic exposure to particulate air pollution and increased mortality, particularly from cardiovascular disease, but fewer studies have examined the association between long-term exposure to fine particulate air pollution and specific cardiovascular events, such as acute myocardial infarction (AMI). Objective: We examined how long-term exposure to area particulate matter affects the onset of AMI, and we distinguished between area and local pollutants. Methods: Building on the Worcester Heart Attack Study, an ongoing community-wide investigation examining changes over time in myocardial infarction incidence in greater Worcester, Massachusetts, we conducted a case–control study of 4,467 confirmed cases of AMI diagnosed between 1995 and 2003 and 9,072 matched controls selected from Massachusetts resident lists. We used a prediction model based on satellite aerosol optical depth (AOD) measurements to generate both exposure to particulate matter ≤ 2.5 μm in diameter (PM$_{2.5}$) at the area level (10 × 10 km) and the local level (100 m) based on local land use variables. We then examined the association between area and local particulate pollution and occurrence of AMI. Results: An interquartile range (IQR) increase in area PM$_{2.5}$ (0.59 μg/m$^3$) was associated with a 16% increase in the odds of AMI (95% CI: 1.04, 1.29). An IQR increase in total PM$_{2.5}$ (area + local, 1.05 μg/m$^3$) was weakly associated with a 4% increase in the odds of AMI (95% CI: 0.96, 1.11). Conclusions: Residential exposure to PM$_{2.5}$ may best be represented by a combination of area and local PM$_{2.5}$, and it is important to consider spatial gradients within a single metropolitan area when examining the relationship between particulate matter exposure and cardiovascular events