Robot-assisted laparoscopic prostatectomy in a 68-year-old patient with previous heart transplantation and pelvic irradiation

We report the case of a 68-year-old man who had previously undergone heart transplantation and pelvic irradiation for Hodgkin’s lymphoma and who was under active surveillance for prostate cancer. In response to his increased prostate-specific antigen levels and elevated Gleason score, he was offered robot-assisted laparoscopic prostatectomy

Behovskartlegging for Fritidsbåtplattformen

Denne rapporten inneholder et detaljrikt kunnskapsgrunnlag for å etablere en digitalt støttet plattform for tverrsektorielt samarbeid mot fritidsbåtulykker. Rapporten inneholder en introduksjon, aktørkartlegging, kartlegging av data og informasjon, beskrivelse av personvernsaspekter, og til sist en oppsummering av utfordringer og mulige løsninger. Rapporten ble oppdatert i løpet av høsten 2022 og våren 2023. Formålet med rapporten er tredelt. For det første er det viktig å dokumentere kunnskapsinnhentingen i prosjektet. For det andre benyttes rapporten som en mulighet for at forskerne får innspill om ytterligere relevant informasjon. Videre har vi sett på dokumentet som et levende arbeidsdokument og oppslagsverk for å skape en omforent forståelse om hva Fritidsbåtplattformens grunnlag og innhold er. Dette medførte at rapporten ble oppdatert gjennom prosjektets levetid og versjon 2 er ved prosjektets slutt. ISBN: 978-82-14-07226-6publishedVersio

A cross-sectional study of current work ability after radical prostatectomy

Background Work ability represents a person’s subjective assessment of current ability to work compared to his lifetime best. Since many men with prostate cancer are retired, work ability represents a more relevant work measure than employment status. The primary aim was to examine the prevalence of men who had high versus moderate/poor current work ability compared to their lifetime best work ability at a mean of 3.0 years after robot-assisted laparoscopic prostatectomy. The secondary aim was to study variables associated with moderate/poor work ability at survey. Methods This is a questionnaire-based study of men who had robot-assisted laparoscopic prostatectomy at Oslo University Hospital, Radiumhospitalet between January 2005 and August 2010. Among them 777 responded (79%), 730 reported on current work ability, socio-demographic data, somatic and mental health, and typical adverse effects (the EPIC-26) after prostatectomy. High versus moderate/poor work ability was the primary outcome. Descriptive statistics and logistic regression analyses were applied. Results The mean age of the sample at survey was 65.5 years (SD 5.9). At survey 42% of the sample reported moderate/poor current work ability and 58% reported high work ability. In multivariable analysis older age at survey, low basic education, comorbidity, poor self-rated health, presence of depression and low EPIC-26 hormonal domain score remained significantly associated with moderate/poor work ability. Conclusions Current work ability is a useful measure for the working capacity particularly of retired men. Socio-demographic, cancer-related, health, psychological and typical adverse effect variables were significantly associated with moderate/poor current work ability after robot-assisted laparoscopic prostatectomy, and several health and psychological variables are amenable to identification and treatment by health care providers

Psychometric properties of the expanded prostate cancer index composite - 26 instrument in a cohort of radical prostatectomy patients: theoretical and practical examinations

Background Recently, the Expanded Prostate Cancer Index Composite 26-item version (EPIC-26) was recommended for the assessment of adverse effects after the treatment of prostate cancer without clear reasons. This decision encouraged us to review the questionnaire development from the UCLA Prostate Cancer Index (UCLA-PCI) to the EPIC-16 CP with a focus on psychometric properties. We also reviewed PubMed for papers concerning such properties of the EPIC-26 since 2012 (latest review in 2011). Finally, we examined the psychometric properties of the EPIC-26 in a sample of Norwegian males treated with robot-assisted laparoscopic prostatectomy (RALP). Methods This study used three methods: (1) Comparison of the content of the UCLA-PCI, EPIC-50, EPIC-26, and EPIC-16 CP; (2) Review of EPIC-26 and EPIC-16 CP papers in PubMed from 2012 to 2016, identifying papers reporting on the psychometric properties of these questionnaires; and (3) Psychometric examination of the EPIC-26 rating in 651 Norwegian men treated with RALP at a mean of 3.2 years post-surgery. Results The questionnaire development showed a significant increase in bother versus function items, and the EPIC-26 contains eight function and 18 bother items. Twelve papers concerning the EPIC-26 available on PubMed since 2012 support the psychometric properties of the EPIC-26. The Norwegian EPIC-26 findings supported the psychometric properties of the EPIC-26, but suggested six subdomains both by exploratory and confirmatory factor analyses. Conclusions In general our examinations supported the adequate psychometric properties of the EPIC-26, although the factor structure, construct and predictive validity of the instrument should be examined further

Multiparametric Magnetic Resonance Imaging of Penile Cancer: A Pictorial Review

The role of multiparametric magnetic resonance imaging (mpMRI) in assessing penile cancer is not well defined. However, this modality may be successfully applied for preoperative staging and patient selection; postoperative local and regional surveillance; and assessments of treatment response after oncological therapies. Previous studies have been mostly limited to a few small series evaluating the accuracy of MRI for the preoperative staging of penile cancer. This review discusses the principles of non-erectile mpMRI, including functional techniques and their applications in evaluating the male genital region, along with clinical protocols and technical considerations. The latest clinical classifications and guidelines are reviewed, focusing on imaging recommendations and discussing potential gaps and disadvantages. The development of functional MRI techniques and the extraction of quantitative parameters from these sequences enables the noninvasive assessment of phenotypic and genotypic tumor characteristics. The applications of advanced techniques in penile MRI are yet to be defined. There is a need for prospective trials and feasible multicenter trials due to the rarity of the disease, highlighting the importance of minimum technical requirements for MRI protocols, particularly image resolution, and finally determining the role of mpMRI in the assessment of penile cance

Multi-parametric MRI without artificial erection for preoperative assessment of primary penile carcinoma: A pilot study on the correlation between imaging and histopathological findings

Purpose: We aimed to evaluate the diagnostic potential of non-erectile multi-parametric magnetic resonance imaging (mpMRI) for preoperative assessment of primary penile squamous cell carcinoma (SCC). Method: Twenty-five patients who underwent surgery for penile SCC were included. Preoperative mpMRI without artificial erection was performed in all patients. The preoperative MRI protocol consisted of high-resolution morphological and functional sequences (diffusion-weighted imaging and dynamic contrast-enhanced MRI perfusion) covering the penis and lower pelvis. T and N staging, according to the 8th edition of the Union for International Cancer Control TNM classification, as well as the largest diameter and thickness/infiltration depth of the primary lesions were determined in all patients. Imaging data were retrospectively collected and compared with the final histopathology reports. Results: Very good agreement was observed between MRI and histopathology for the involvement of corpus spongiosum (p = 0.002) and good agreement was observed for the involvement of penile urethra and tunica albuginea/corpus cavernosum (p < 0.001 and p = 0.007, respectively). Good agreement was observed between MRI and histopathology for overall T staging and weaker, but still good agreement was observed for N staging (p < 0.001 and p = 0.002, respectively). A strong and significant correlation was observed between MRI and histopathology for the largest diameter and thickness/infiltration depth of the primary lesions (p < 0.001). Conclusions: Good concordance was observed between MRI and histopathological findings. Our initial findings indicate that non-erectile mpMRI is useful in preoperative assessment of primary penile SCC

Regnskapsanalyse av Birger N. Haug AS

Det er i denne semesteroppgaven gjennomført en regnskapsanalyse av bilforhandleren Birger N. Haug AS for å analysere lønnsomhetsutviklingen i selskapet. Den aktuelle perioden er fra 2017 til 2020, og det er i tillegg undersøkt mulige årsaker til lønnsomhetsutviklingen. For å svare på oppgavens problemstilling på best mulig måte ble det inngått et samarbeid med Birger N. Haug. På denne måten er beregning av nøkkeltall og drøfting av den økonomiske situasjonen til selskapet i den aktuelle perioden basert både på regnskapstall hentet fra proff.no og innspill fra selskapet selv. Det er benyttet relevante nøkkeltall innenfor lønnsomhet, likviditet, finansiering og soliditet for å danne et helhetlig bilde av lønnsomhetsutviklingen i perioden 2017 til 2020. I tillegg er det benyttet nøkkeltall innenfor lønnsomhet, likviditet og soliditet for å sammenligne med relevante konkurrenter. Det er bilforhandlerne Mobile og RøhneSelmer som er å anse som de mest aktuelle konkurrentene for Birger N. Haug i henhold til selskapet selv, og som følgelig er sammenligningsgrunnlaget for benchmarkingen. Gjennom personlig intervju og kommunikasjon via epost med styreleder i Birger N. Haug og selskapets økonomisjef ble det dannet grunnlag for å gjennomføre en SWOT-analyse. Denne analysen er bakgrunnen for drøftingen av mulige årsaker til lønnsomhetsutviklingen til Birger N. Haug i den aktuelle perioden. I 2018 opplevde selskapet en stor forbedring i lønnsomheten samt en positiv utvikling i nøkkeltallene sammenlignet med tidligere regnskapsår. Hovedårsaken til dette var introduksjonen av en ny elektrisk bilmodell fra et bilmerke Birger N. Haug selger. Denne bilmodellen ble særdeles populær ved lansering og selskapet solgte følgelig mange eksemplarer. Elektrisk bil har de siste årene blitt et populært alternativ til fossildrevet bil, som har vært fordelaktig for Birger N. Haug ettersom de tilbyr et bredt utvalg av elbiler. Sammenlignet med de relevante konkurrentene har selskapet følgelig opplevd en god utvikling i lønnsomheten fra 2018 til 2020

Routine pelvic MRI using phased-array coil for detection of extraprostatic tumour extension: accuracy and clinical significance

Objectives To determine the accuracy and assess the clinical significance of surface-coil 1.5-T magnetic resonance imaging (MRI) for the detection of locally advanced prostate cancer (PCa). Methods Between December 2007 and January 2010, we examined 209 PCa patients (mean age = 62.5 years) who were consecutively treated with robot-assisted laparoscopic prostatectomy and prospectively staged by MRI. One hundred and thirty-five patients (64.6 %) had locally advanced disease. Conventional clinical tumour stage and MRI-assessed tumour stage were compared with histopathological tumour stage (pT). Sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV) and overall accuracy (OA) were calculated using pT as the “gold standard”. Overstaged and understaged cases at MRI were reviewed. Results Sensitivity, specificity, PPV, NPV and OA for the detection of locally advanced disease were 25.9, 95.9, 92.1, 41.2 and 50.5 % and 56.3, 82.2, 85.4, 50.4 and 65.4 % for clinical staging and MRI, respectively. Among patients understaged at MRI, the resection margins were free in 64.4 % of the cases (38/59). Conclusions Although the accuracy was limited, the detection of locally advanced disease improved substantially when MRI was added to routine clinical staging. The majority of the understaged patients nevertheless achieved free margins. When assessing the clinical significance of MRI staging the extent of extraprostatic extension has to be considered. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited