X-Ray Structure and In Vitro Anti-Tumoural Activity of the Dimeric Bis[(2-Phenyl-1,2-Dicarba-Closo-Dodecaborane-1-Carboxylato)-Di-n-Butyltin] Oxide

X-ray diffraction studies reveal the structure of {[(2-C6H5-1,2-C2B10H10-1-COO)Bu2Sn]2O}2, 1, to conform to the common motif found for {[(R′COO)R2Sn]2O}2 compounds. The dimer features a central Bu2Sn2O2 unit (two-fold symmetry) with the two Bu2Sn groups being linked via bridging oxygen atoms, each of which also carries an exocyclic Bu2Sn moiety. The two pairs of exo- and endo-cyclic tin atoms are each linked via an almost symmetrically bridging carboxylate ligand and the two remaining ligands coordinate an exocyclic tin atom only, in the monodentate mode. The in vitro anti-tumour activity of 1, determined against a variety of cell lines, is compared with those of the corresponding 2-methylcarboranylacetate, derivative 2, and with clinically used compounds

SOME METHODS OF OPTIMIZATION OF TREATMENT OF PURULENT SURGICAL INFECTION

Treatment of 3 groups of patients with purulent surgical infection was analyzed. In the first group of patients (15) with extensive purulent necrotic wounds hydrosurgical method. (Versajet) was used, that allowed to prepare the wound for autoplasty or to achieve self-epithelization. In the second group of patients (64) with the most common forms of purulent surgical infection at the local treatment electroactivated water solutions (anolyte, catholyte) were used. Their application promoted smooth course of wound process and decrease of terms of treatment. In the third group of patients (16) with vast traumatic area existing during the long time in the regeneration. phase heterogeneous fibrin was locally applied. Activation of granulation process and of islet and. marginal epithelialization was marked