Opening the black box: How staff training and development may affect the innovation of enterprises

We describe a research on the interplay that appears to exist in companies between Human Resource Management and innovation. This complex, multicomponent, non-linear and dynamic interplay is often viewed as a "black box". To help open the black box, we outline both a theoretical framework and preliminary empirical data. We view innovation as an organization-level property, favored by the organization's self-perception as a knowledge engine. Therefore, we devised a protocol to study the companies' strategies for training and development and their innovation profile. The protocol consisted in a questionnaire with 100 closed questions, suitable for companies which rely mostly on an inner training and development service. The questionnaire was administered to a sample of Italian firms from the Food & beverages and Fashion markets. The results show that certain facets of training and development are indeed correlated to innovation. Finally, we discuss the results

Does DKC1 Mutation Suffice to Define the Phenotype Severity of Hoyeraal-Hreidarsson Syndrome? *

ABSTRACT Both dyskeratosis congenita (DC) and Hoyeraal-Hreidarsson Syndrome (HHS) are rare inherited bone marrow failure conditions. HHS is considered to be a variant of DC in which neurological deficits and immunodeficiencies are also present. We describe a very interesting familial cluster where an invariant point mutation of DKC1 located in the exon 11 is observed in the carrier mother and in two decedent males. The older child developed the classical phenotype of HHS at a very early age. The second affected child remains poorly symptomatic, with only mild haematological changes. Telomere shortening, with different severity, is also present in both cases. This paper discusses the clinical spectrum of inherited BM failure syndromes from the perspective different clinical presentation within a family with a DKC1 mutation