6 research outputs found
Alcohol-induced Cushing syndrome: report of eight cases and review of the literature
- Author
- Publication venue
- 'Frontiers Media SA'
- Publication date
- 01/06/2023
- Field of study
IntroductionAlcohol-induced hypercortisolism (AIH) is underrecognized and may masquerade as neoplastic hypercortisolism [Cushing syndrome (CS)] obscuring its diagnosis.Objective and methodsIn order to characterize AIH, we performed a chart review of eight patients (4 males and 4 females; 2014-2022) referred for evaluation and treatment of neoplastic hypercortisolism — six for inferior petrosal sinus sampling, one due to persistent CS after unilateral adrenalectomy, and one for pituitary surgery for Cushing disease (CD). Five underwent dDAVP stimulation testing.ResultsAll eight patients had clinical features of hypercortisolism and plasma ACTH levels within or above the reference interval confirming hypothalamic-pituitary mediation. All had abnormal low-dose dexamethasone suppression test and increased late-night salivary cortisol. Only one had increased urine cortisol excretion. In contrast to CD, the 5 patients tested had blunted or absent ACTH and cortisol responses to desmopressin. Two had adrenal nodules and one had abnormal pituitary imaging. Most patients underreported their alcohol consumption and one denied alcohol use. Elevated blood phosphatidyl ethanol (PEth) was required in one patient to confirm excessive alcohol use. All patients had elevations of liver function tests (LFTs) with AST>ALT.ConclusionAIH is an under-appreciated, reversible cause of non-neoplastic hypercortisolism that is indistinguishable from neoplastic CS. Incidental pituitary and adrenal imaging abnormalities as well as under-reporting of alcohol consumption further confound the diagnosis. Measurement of PEth helps to confirm an alcohol use disorder. Elevations of LFTs (AST>ALT) and subnormal ACTH and cortisol responses to dDAVP help to distinguish AIH from neoplastic hypercortisolism
New cutoffs for the biochemical diagnosis of adrenal insufficiency after ACTH stimulation using specific cortisol assays
- Author
- Publication venue
- Advocate Aurora Health Institutional Repository
- Publication date
- 18/02/2021
- Field of study
Context: The normal cortisol response 30 or 60 minutes after cosyntropin (ACTH[1-24]) is considered to be ≥18 μg/dL (500 nmol/L). This threshold is based on older serum cortisol assays. Specific monoclonal antibody immunoassays or LC-MS/MS may have lower thresholds for a normal response.
Objective: To calculate serum cortisol cutoff values for adrenocorticotropic hormone (ACTH) stimulation testing with newer specific cortisol assays.
Methods: Retrospective analysis of ACTH stimulation tests performed in ambulatory and hospitalized patients suspected of adrenal insufficiency (AI). Serum samples were assayed for cortisol in parallel using Elecsys I and Elecsys II immunoassays, and when volume was available, by Access immunoassay and LC-MS/MS.
Results: A total of 110 patients were evaluated. Using 18 ÎĽg/dL as the cortisol cutoff after ACTH stimulation, 14.5%, 29%, 22.4%, and 32% of patients had a biochemical diagnosis of AI using the Elecsys I, Elecsys II, Access, and LC-MS/MS assays, respectively. Deming regressions of serum cortisol were used to calculate new cortisol cutoffs based on the Elecsys I cutoff of 18 ÎĽg/dL. For 30-minute values, new cutoffs were 14.6 ÎĽg/dL for Elecsys II, 14.8 ÎĽg/dL for Access, and 14.5 ÎĽg/dL for LC-MS/MS. Baseline cortisol \u3c2 ÎĽg/dL was predictive of subnormal stimulated cortisol values.
Conclusion: To reduce false positive ACTH stimulation testing, we recommend a new serum cortisol cutoff of 14 to 15 ÎĽg/dL depending on the assay used (instead of the historical value of 18 ÎĽg/dL with older polyclonal antibody assays). Clinicians should be aware of the new cutoffs for the assays available to them when evaluating patients for AI
Response to the letter to the editor From Jialal and Sood: New cutoffs for the biochemical diagnosis of adrenal insufficiency after ACTH stimulation using specific cortisol assays
- Author
- Publication venue
- Advocate Aurora Health Institutional Repository
- Publication date
- 04/07/2021
- Field of study
Examining the linguistic coding differences hypothesis to explain individual differences in foreign language learning
- Author
- A. Durgunoglu
- A. Fowler
- A. Fowler
- A. Guiora
- C. Seashore
- D. Ho
- D. Shankweiler
- E Wiig
- E. Horwitz
- E. Service
- F. Vellutino
- H. Catts
- I. Liberman
- I. Liberman
- J. Carroll
- J. Carroll
- J. Carroll
- J. Fletcher
- J. Fodor
- J. Javorsky
- J. Tiedemann
- K. Butler
- K. Kavale
- K. Koda
- K. Stanovich
- K. Stanovich
- K. Stanovich
- K. Stanovich
- K. Stanovich
- L. Bradley
- L. Bradley
- L. Ehri
- L. Ganschow
- L. Ganschow
- L. Ganschow
- L. Ganschow
- L. Ganschow
- L. Ganschow
- L. Ganschow
- L. Stanovich
- M. Ehrman
- M. Ehrman
- M. Humes-Bartlo
- M. Long
- P. MacIntyre
- P. MacIntyre
- P. Pimsleur
- P. Pimsleur
- P. Pimsleur
- P. Pimsleur
- P. Skehan
- P. Skehan
- P. Skehan
- R. Gardner
- R. Gardner
- R. Leutenegger
- R. Leutenegger
- R. Oxford
- R. Oxford
- R. Sparks
- R. Sparks
- R. Sparks
- R. Sparks
- R. Sparks
- R. Sparks
- R. Sparks
- R. Sparks
- R. Sparks
- R. Sparks
- R. Sparks
- R. Sparks
- R. Sparks
- R. Sparks
- R. Wagner
- Richard L. Sparks
- S. Au
- S. Brady
- S. Crain
- S. Gass
- S. Gathercole
- S. Krashen
- S. Smith
- V. Mann
- V. Mann
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
The effects of multisensory structured language instruction on native language and foreign language aptitude skills of at-risk high school foreign language learners
- Author
- A. Content
- A. Cox
- A. Gajar
- A. Gillingham
- A. Omaggio
- B. Guyer
- B. Myer
- B. Myer
- C. Herron
- C. Perfetti
- D. Shankweiler
- E. Ball
- E. Ball
- E. Horwitz
- E. Horwitz
- F. Vellutino
- G. Daggett
- I. Liberman
- I. Liberman
- I. Liberman
- I. Liberman
- I. Lundberg
- I. Lundberg
- J. Carroll
- J. Carroll
- J. Carroll
- J. Carroll
- J. Carroll
- J. Carroll
- J. Javorsky
- J. Lerner
- J. Oller
- J. Oller
- J. Oller
- J. Williams
- Jane Pohlman
- K. Demuth
- K. Dinklage
- K. Stanovich
- K. Stanovich
- K. Stanovich
- K. Vickery
- L. Bradley
- L. Dunn
- L. Ganschow
- L. Ganschow
- L. Ganschow
- L. Ganschow
- L. Ganschow
- L. Hutcheson
- L. Keeney
- Leonore Ganschow
- M. Adams
- M. Brightman
- M. Enfield
- M. Fowler
- M. L. Enfield
- M. Levine
- Marjorie Artzer
- N. Elson
- N. Pompian
- N. Royal
- N. White
- P. G. Aaron
- P. Lindamood
- P. Pimsleur
- P. Pimsleur
- P. Pimsleur
- P. Pimsleur
- P. Pimsleur
- R. Frankiewicz
- R. Gardner
- R. Gardner
- R. Lefebvre
- R. Oxford
- R. Sparks
- R. Sparks
- R. Sparks
- R. Sparks
- R. Sparks
- R. Valette
- R. Woodcock
- R. Woodcock
- Richard Sparks
- S. Au
- S. Crain
- S. Gathercole
- S. Gathercole
- S. Jastak
- S. Krashen
- S. Smith
- Sue Skinner
- T. Terrell
- T. Terrell
- V. Greene
- V. Greene
- V. Mann
- V. Mann
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
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- R Keller
- R Kirchner
- R Koch
- R Liljestrand
- R Littauer
- R Madey
- R Mckeown
- R Moreh
- R Moreh
- R Moreh
- R Neuhausen
- R Nobles
- R Pitthan
- R Pretorius
- R Redstone
- R Rieppo
- R Risler
- R Romain
- R Schaeffer
- R Schormann
- R Shyam
- R Siebel
- R Sigel
- R Speidel
- R Stock
- R Stroffolini
- R Swiniarski
- R Swiniarski
- R Swiniarski
- R Swiniarski
- R Vandenbosch
- R Vandenbosch
- R Vandenbosch
- R Vandenbosch
- R Vandenbosch
- R Vennink
- R Verbruggen
- R Vyver
- R Weinreich
- RA Anderl
- RA Dayras
- RA Dayras
- RA Eisenstein
- RA Emigh
- RA Friedenberg
- RA Lindgren
- RA PrĂĽmmer
- RA Smith
- RB Brownell
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- RB Weinberg
- RC Block
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- RD Baybarz
- RD Bent
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- RD Wendling
- RE Anderson
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- RE Marrs
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- RE Warner
- RF Barrett
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- RG Stokstad
- RG Stokstad
- RH Parker
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- RI Tarara
- RJ Burt
- RJ Dupzyk
- RJ Girnius
- RJ Holt
- RJ Holt
- RJ Holt
- RJ Holt
- RJ Mason
- RJ Meijer
- RJ Mitchell
- RJ Peterson
- RJ Peterson
- RJ Schneider
- RJ Sparks
- RJ Sparks
- RJ Sparks
- RK Bhowmik
- RK Jolly
- RK Srinivasa
- RK Tenhaken
- RL Anderson
- RL Anderson
- RL Auble
- RL Blanchard
- RL Crawley
- RL Gill
- RL Macklin
- RL Macklin
- RL Meek
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- RL Robinson
- RL Robinson
- RL Walraven
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- RM Chaudhri
- RM Delvecchio
- RM Freeman
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- RM Ronningen
- RM Ronningen
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- RM Sealock
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- RN Boyd
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- RR Betts
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- RR Johnson
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- RR Silbar
- RR Spencer
- RR Spencer
- RR Stone
- RR Wilson
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- RS Hickman
- RS Hicks
- RS Revell
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- RS Timsit
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- RT Santoro
- RT Santoro
- RW Adam
- RW Benjamin
- RW Berry
- RW Bickes Jr.
- RW Dressel
- RW Finlay
- RW Hockenbury
- RY Cusson
- S Agarwal
- S Ahmad
- S Andre
- S Barshay
- S Bederka
- S Biswas
- S Bjornholm
- S Cierjacks
- S Cierjacks
- S Cierjacks
- S Cochavi
- S Cotelle
- S Datz
- S Davis
- S Diliberto
- S Dushman
- S Dushman
- S El-Kazzaz
- S Frankel
- S Frankel
- S Furui
- S Furui
- S Furyi
- S Gales
- S Gales
- S Gales
- S Gales
- S Gerstenkorn
- S Gorodetzky
- S Grimes
- S Hillebrand
- S Hiramatsu
- S Hlavac
- S Isagawa
- S Iversen
- S Kahane
- S Kato
- S Kato
- S Landowne
- S Lovell
- S Matsuda
- S Matsuki
- S Michalowski
- S Mrozowski
- S Nagy
- S Notarrigo
- S Ogawa
- S Oikawa
- S Pandian
- S Raman
- S Raman
- S Skorka
- S Szalay
- S Takayanagi
- S Takeuchi
- S Takeuchi
- S Tryti
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- S Wynchank
- S Wynchank
- S Yamaji
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- SA Azimov
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- SA Wender
- SA Wender
- SA Wender
- SB Kaufman
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- SF Mughabghab
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- SH Maxman
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- SI Anisimov
- SJ Freedman
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- SM Barr
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- SU Eckroad
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- T Ando
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- T Bauer
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- T Inamura
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- TE Albert
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- TH Hsu
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- TS Lee
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- TS Noggle
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- TT Bardin
- TU Chan
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- U Berghaus
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- U Kneissl
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- U Strohbusch
- UC Corwin
- UN Singh
- UN Singh
- UN Singh
- V Andersen
- V Bechtold
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- V Bechtold
- V Chabaud
- V Chatoorgoon
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- V Franco
- V Halpern
- V Koenig
- V Krivan
- V Lantto
- V Manaooli
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- V Verdinah
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- V Verdingh
- V Verdingh
- V Verdingh
- V Verdingh
- V Verdingh
- V Verdingh
- VA Gladyshev
- VB Dedov
- VD Anan’ev
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- VD Avchukhov
- VD Bartenev
- VD Bartenev
- VD Bartenev
- VD Scott
- VE Bunakov
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- VF Kharchenko
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- VG Zlobin
- VI Bol’shov
- VI Borovlev
- VI Chigin’
- VI Gridasov
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- VI Komarov
- VI Kotov
- VI Petrov
- VI Serov
- VI Strizhak
- VI Strizhak
- VI Strizhak
- VK Daruga
- VM Khvastunov
- VM Kolybasov
- VN Karev
- VN Kononov
- VN Kononov
- VN Kononov
- VN Kononov
- VN Medyanik
- VN Medyanik
- VN Medyanik
- VP Alfimenkov
- VP Badovskii
- VP Bochin
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- VP Zrelov
- VS Butsev
- VS Letkhov
- VS Prokopenko
- VT Tustanovskii
- VV Surenyants
- VV Tokarevskij
- VV Varlamov
- VY Golovnya
- W Arnold
- W Ash
- W Assmann
- W Bertozzi
- W Bianco
- W Brueckner
- W Bucher
- W Dietrich
- W Drenckhahn
- W Drenckhahn
- W Eckstein
- W Fitz
- W Forsling
- W Galster
- W Gelletly
- W Henning
- W Kohler
- W Kohler
- W Kreische
- W Kroll
- W Kuhn
- W Kuhn
- W Kutschera
- W Meckback
- W Moller
- W Niessner
- W Parker
- W Schaeffer
- W Smolec
- W Smolec
- W Stach
- W Steckelmacher
- W Steinkilberg
- W Tietsch
- W Tietsch
- W Tornow
- W Trautmann
- W Treu
- W Whaling
- W Wilcke
- W Witsch
- WA Friedman
- WA Gillespie
- WA Schier
- WA Seale
- WA Sedlacek
- WA Sedlacek
- WA Sterrenburg
- WB Cook
- WC Parker
- WC Parker
- WC Parker
- WD Ramsay
- WD Riel
- WD Schmidt-Ott
- WD Westwood
- WE Burcham
- WE Frahn
- WF Schneider
- WG Cross
- WG Davies
- WG Love
- WG Love
- WG Williams
- WH Evans
- WH Mcadams
- WH Wong
- WJ Braithwaite
- WJ Knox
- WJ Lindsey
- WJ Oosterkamp
- WJ Sturm
- WJ Wallace
- WJ Weisehahn
- WK Dagenhart
- WK Dagenhart
- WL Reiter
- WM Currie
- WM Gibson
- WP Alford
- WP Eeghem
- WP Hwang
- WP Hwang
- WP Poenitz
- WP Poenitz
- WR Dixon
- WR Dixon
- WR Falk
- WR Falk
- WR Gibbs
- WR Gibbs
- WR Gibbs
- WR Gibbs
- WR Hering
- WR Phillips
- WR Wylie
- WR Wylie
- WV Conner
- WV Hassenzahl
- Wvander Eijk
- WW Bowman
- WW Daehnick
- WZ Wade
- Y Abgrall
- Y Alexander
- Y Alexander
- Y Avishai
- Y Bornec
- Y Chanut
- Y Chanut
- Y Chanut
- Y Civelekoglu
- Y Dar
- Y Dmitrevskii
- Y Eisen
- Y Eisenberg
- Y Futami
- Y Iwasaki
- Y Kagawa
- Y Kanda
- Y Leduigou
- Y Masri
- Y Shamai
- Y Sugiyama
- Y Suzuki
- Y Uemura
- Y Yamazaki
- Y Yang
- YA Berdnikov
- YA Berezhnoj
- YA Shcherbakov
- YA Volchek
- YD Bayukov
- YG Mashkarov
- YG Sevast’yanov
- YH Shen
- YK Gavrilov
- YP Antuf’ev
- YP Dmitrevskii
- YR Gismatullin
- YS Horowitz
- YS Korotkin
- YT Borzunov
- YT Borzunov
- YT Borzunov
- YT Borzunov
- Yu Gorodkov V
- Yu Sevast’yanov
- YW Lui
- YY Chu
- Z Basrak
- Z Fraenkel
- Z Hulek
- Z Majka
- Z Zinamon
- ZE Switkowski
- ZE Switkowski
- ZE Switkowski
- ZE Switkowski
- ZE Switkowski
- ZG Werner
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/1981
- Field of study