Microwave Radiometer (MWR) Evaluation of Multi-Beam Satellite Antenna Boresight Pointing Using Land-Water Crossings, for the Aquarius/SAC-D Mission

This research concerns the CONAE Microwave Radiometer (MWR), on board the Aquarius/SAC-D platform. MWR\u27s main purpose is to provide measurements that are simultaneous and spatially collocated with those of NASA\u27s Aquarius radiometer/scatterometer. For this reason, knowledge of the MWR antenna beam footprint geolocation is crucial to mission success. In particular, this thesis addresses an on-orbit validation of the MWR antenna beam pointing, using calculated MWR instantaneous field of view (IFOV) centers, provided in the CONAE L-1B science data product. This procedure compares L-1B MWR IFOV centers at land/water crossings against high-resolution coastline maps. MWR IFOV locations versus time are computed from knowledge of the satellite\u27s instantaneous location relative to an earth-centric coordinate system (provided by on-board GPS receivers), and a priori measurements of antenna gain patterns and mounting geometry. Previous conical scanning microwave radiometer missions (e.g., SSM/I) have utilized observation of rapid change in brightness temperatures (T_B) to estimate the location of land/water boundaries, and subsequently to determine the antenna beam-pointing accuracy. In this thesis, results of an algorithm to quantify the geolocation error of MWR beam center are presented, based upon two-dimensional convolution between each beam\u27s gain pattern and land-water transition. The analysis procedures have been applied to on-orbit datasets that represent land-water boundaries bearing specific desirable criteria, which are also detailed herein. The goal of this research is to gain a better understanding of satellite radiometer beam-pointing error and thereby to improve the geolocation accuracy for MWR science data products

Comparison of Super Resolution Reconstruction Acquisition Geometries for Use in Mouse Phenotyping

3D isotropic imaging at high spatial resolution (30–100 microns) is important for comparing mouse phenotypes. 3D imaging at high spatial resolutions is limited by long acquisition times and is not possible in many in vivo settings. Super resolution reconstruction (SRR) is a postprocessing technique that has been proposed to improve spatial resolution in the slice-select direction using multiple 2D multislice acquisitions. Any 2D multislice acquisition can be used for SRR. In this study, the effects of using three different low-resolution acquisition geometries (orthogonal, rotational, and shifted) on SRR images were evaluated and compared to a known standard. Iterative back projection was used for the reconstruction of all three acquisition geometries. The results of the study indicate that super resolution reconstructed images based on orthogonally acquired low-resolution images resulted in reconstructed images with higher SNR and CNR in less acquisition time than those based on rotational and shifted acquisition geometries. However, interpolation artifacts were observed in SRR images based on orthogonal acquisition geometry, particularly when the slice thickness was greater than six times the inplane voxel size. Reconstructions based on rotational geometry appeared smoother than those based on orthogonal geometry, but they required two times longer to acquire than the orthogonal LR images

Unexpectedly high prevalence of sarcoidosis in a representative U.S. Metropolitan population

SummaryThe prevalence of sarcoidosis in the United States is unknown, with estimates ranging widely from 1 to 40 per 100,000. We sought to determine the prevalence of sarcoidosis in our health system compared to other rare lung diseases and to further establish if the prevalence was changing over time. We interrogated the electronic medical records of all patients treated in our health system from 1995 to 2010 (1.48 million patients) using the common ICD9 codes for sarcoidosis (135), lung cancer (162), and several other lung diseases characterized, like sarcoidosis, as “rare lung diseases”. The patient demographic information (race, gender, age) was further analyzed to identify signature data patterns. The prevalence of sarcoidosis in our health system increased steadily from 164/100,000 in 1995 to 330/100,000 in 2010, and this trend could not be ascribed simply to changes in patient demographics or patient referral patterns. We further estimate that the prevalence of sarcoidosis exceeds 48 per 100,000 in Franklin County, Ohio, the demographic profile of which is nearly identical to that of the U.S. Sarcoidosis prevalence increased over time relative to lung cancer, a benchmark disease with stable disease prevalence, and exceeded that of other rare lung diseases. We postulate that the observed 2-fold increase in sarcoidosis disease prevalence in our health system is primarily related to improved detection and diagnostic approaches, and we conclude that the actual prevalence of sarcoidosis in central Ohio greatly exceeds current U.S. estimates

Microwave Radiometer (Mwr) Beam-Pointing Validation For The Aquarius/Sac-D Mission

The Aquarius/SAC-D joint international science mission, a collaborative effort between NASA and the Argentine Space Agency, CONAE, was launched on June 10, 2011. The purpose of the Aquarius/SAC-D mission is to provide measurements of global sea surface salinity (SSS), which will be used to understand climatic changes of the global water cycle and how these changes influence the general ocean circulation. © 2014 IEEE