Reaction kinetics and mechanismsof organosilicon fungicide flusilazole with sulfate and hydroxyl radicals

[EN] Flusilazole is an organosilane fungicide used for treatments in agriculture and horticulture for control of diseases. The reaction kinetics and mechanism of flusilazole with sulfate and hydroxyl radicals were studied. The rate constant of the radicals with the fungicide were determined by laser flash photolysis of peroxodisulfate and hydrogen peroxide. The results were 2.0 x 10(9) s(-1)M(-1) for the reaction of the fungicide with HO center dot and 4.6 x 10(8) s(-1) M-1 for the same reaction with SO4 center dot- radicals. The absorption spectra of organic intermediates detected by laser flash photolysis of S2O82- with flusilazole, were identified as alpha-aminoallcyl and siloxyl radicals and agree very well with those estimated employing the time-dependent density functional theory with explicit account for bulk solvent effects. In the continuous photolysis experiments, performed by photo-Fenton reaction of the fungicide, the main degradation products were: (bis(4-fluorophenyl)-hydroxy-methylsilane) and the non-toxic silicic acid, diethyl bis(trimethylsilyl) ester, in ten and twenty minutes of reaction, respectively. (C) 2017 Published by Elsevier Ltd.DFM thanks Consejo Nacional de Investigaciones Cientificas y Tecnicas (CONICET, Argentina) for a graduate studentship. MCG and PC are research members of CONICET, Argentina. This research was supported by grant PICT 2012-2359 from ANPCyT. Financial support for academic interchange by the European Union (IRSES-GA-2010-269128, EnvironBOS) is acknowledged.Mercado, D.; Bracco, LLB.; Arqués Sanz, A.; González, MC.; Caregnato, P. (2018). Reaction kinetics and mechanismsof organosilicon fungicide flusilazole with sulfate and hydroxyl radicals. Chemosphere. 190:327-336. https://doi.org/10.1016/j.chemosphere.2017.09.134S32733619

Multivariate hierarchical model for physical inactivity among public school children

OBJECTIVE: To identify biological and sociodemographic factors associated with physical inactivity in public school children. METHODS: Parents of 2,519 children (49.3% of whom were girls), aged 7 to 10 years (mean = 7.6±0.9 years), from eight public schools in São Paulo, Brazil, completed a self-administered questionnaire. We used multiple correspondence analysis to identify groups of responses related to levels of physical activity and inactivity and to obtain an optimal scale. The cluster analysis identified groups of active and inactive children. The analysis of the receiver operator characteristic (ROC) curve, for the study of diagnostic properties of a simplified scale for physical inactivity derived from the optimal scale, revealed that a cutoff point of 3 had the best sensitivity and specificity, being therefore used as outcome variable in the regression model. A multivariate hierarchical model was built, including distal and proximal categorical variables, with a p < 0.05. RESULTS: Physical inactivity was positively associated with biological factors such as being overweight, being older than 7.5 years, being a female, and having a good appetite, and with socioeconomic factors such as having garbage collected less than twice a week and having mothers who work outside the home. CONCLUSION: The results are consistent with published data about determinant factors of physical activity and inactivity among children, showing that questionnaires answered by parents and submitted to a sophisticated statistical analysis can be used in population-based studies involving children younger than 10 years old.OBJETIVO: Identificar fatores biológicos e sociodemográficos atribuíveis à inatividade física em crianças de escolas públicas. MÉTODOS: Foram estudadas, através de questionário auto-relatado pelos pais, 2.519 crianças (49,3% meninas), de 7 a 10 anos (média = 7,6±0,9 anos), de oito escolas públicas da cidade de São Paulo. Aplicamos a análise de correspondência múltipla para identificar grupos de respostas relacionadas com padrões de atividade e inatividade física e a geração de uma escala ótima. A análise de agrupamento identificou os grupos de crianças ativas e inativas. A análise de curva ROC (receiver operator characteristic), para o estudo das propriedades diagnósticas de uma escala simplificada de inatividade física derivada da escala ótima, mostrou o ponto de corte = 3 como o de melhor sensibilidade e especificidade, sendo utilizado como a variável de resposta no modelo de regressão. Um modelo hierárquico multivariado foi construído, assumindo variáveis categóricas como distais e proximais, adotando-se p < 0,05. RESULTADOS: A inatividade física foi positivamente associada aos fatores determinantes biológicos como sobrepeso, idade maior do que 7,5 anos, sexo feminino e bom apetite, e aos determinantes socioeconômicos como freqüência de coleta de lixo menor do que duas vezes por semana e mães que trabalham fora de casa. CONCLUSÃO: Os resultados são coerentes com os dados publicados sobre fatores determinantes de atividade e inatividade física na infância, indicando que questionários respondidos pelos pais, submetidos a uma análise estatística sofisticada, podem ser viáveis em estudos populacionais envolvendo crianças menores de 10 anos.Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Universidade Federal de São Paulo (UNIFESP) Escola Paulista de MedicinaCenter for Physical Activity and Health PromotionCenters for Disease Control and Prevention Division of Nutrition and Physical ActivityUNIFESP-EPM Departamento de PediatriaUNIFESP, EPM, Depto. de PediatriaSciEL

Ultra High Molecular Weight Polyethylene is Cytotoxic and Causes Oxidative Stress, Even When Modified:

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Vibrations of a chain of Xe atoms in a groove of carbon nanotube bundle

We present a lattice dynamics study of the vibrations of a linear chain of Xe adsorbates in groove positions of a bundle of carbon nanotubes. The characteristic phonon frequencies are calculated and the adsorbate polarization vectors discussed. Comparison of the present results with the ones previously published shows that the adsorbate vibrations cannot be treated as completely decoupled from the vibrations of carbon nanotubes and that a significant hybridization between the adsorbate and the tube modes occurs for phonons of large wavelengths.Comment: 3 PS figure

Integrins in masseter muscle in unilateral crossbite patients: an immunohistochemical and molecular study

Integrins are a large family of transmembrane heterodimeric receptors that play a key role in cell adhesion, differentiation, remodelling and tissue repair. b1D isoform is detected only in skeletal and cardiac muscle, while very low amounts of b1A were detected by immunoblot in striated muscles. b1D isoform was associated with a7A and a7B in adult skeletal muscle. Although many studies have been performed on the integrins in adult skeletal muscle, insufficient data exist on behaviour of these proteins in masseter muscle. About this muscles it was demonstrated that they have several differences in respect to limb and trunk muscles. Generally, fibers in the masseter muscle are smaller than fibers in limb and trunk muscles. Consequently, the smaller muscle fibers may be advantageous for the jaw muscles. On this basis, we performed an immunohistochemical and molecular study in order to analyze the behaviour of integrins in normal masseter muscle of both side; moreover, to better comprehend the role of these proteins, we also analyzed masseter muscles of patients affected by unilateral crossbite. Interestingly, our result, integrating with astatistical analysis, showed that, on patients affected by right crossbite, the integrins are substantially less, in both masseters, than those observed in control subjects; in right masseter, the amount of integrin appeared less than the amount of integrins detected in left counterpart. Since kinematics and electromyography study have been demonstrated that masseters of the crossbite side were less active than non-affected side, our results, showing a decrease of integrins in the masseter of crossbite side, allow to hypothesize that the integrins, and in particular alfa7A and beta1A integrins, could play a crucial role in the control of contraction activity

Reaction kinetics and mechanisms of organosilicon fungicide flusilazole with sulfate and hydroxyl radicals

Flusilazole is an organosilane fungicide used for treatments in agriculture and horticulture for control of diseases. The reaction kinetics and mechanism of flusilazole with sulfate and hydroxyl radicals were studied. The rate constant of the radicals with the fungicide were determined by laser flash photolysis of peroxodisulfate and hydrogen peroxide. The results were 2.0 × 109 s-1M-1 for the reaction of the fungicide with HO· and 4.6 × 108 s-1 M-1 for the same reaction with SO4·⁻ radicals. The absorption spectra of organic intermediates detected by laser flash photolysis of S2O2/8⁻ with flusilazole, were identified as α-aminoalkyl and siloxyl radicals and agree very well with those estimated employing the time-dependent density functional theory with explicit account for bulk solvent effects. In the continuous photolysis experiments, performed by photo-Fenton reaction of the fungicide, the main degradation products were: (bis(4-fluorophenyl)-hydroxy-methylsilane) and the non-toxic silicic acid, diethyl bis(trimethylsilyl) ester, in ten and twenty minutes of reaction, respectively.Facultad de Ciencias ExactasInstituto de Investigaciones Fisicoquímicas Teóricas y Aplicada

Prevalência de programas de promoção da saúde em unidades básicas de saúde no Brasil

OBJECTIVE Assessment of prevalence of health promotion programs in primary health care units within Brazil’s health system. METHODS We conducted a cross-sectional descriptive study based on telephone interviews with managers of primary care units. Of a total 42,486 primary health care units listed in the Brazilian Unified Health System directory, 1,600 were randomly selected. Care units from all five Brazilian macroregions were selected proportionally to the number of units in each region. We examined whether any of the following five different types of health promotion programs was available: physical activity; smoking cessation; cessation of alcohol and illicit drug use; healthy eating; and healthy environment. Information was collected on the kinds of activities offered and the status of implementation of the Family Health Strategy at the units. RESULTS Most units (62.0%) reported having in place three health promotion programs or more and only 3.0% reported having none. Healthy environment (77.0%) and healthy eating (72.0%) programs were the most widely available; smoking and alcohol use cessation were reported in 54.0% and 42.0% of the units. Physical activity programs were offered in less than 40.0% of the units and their availability varied greatly nationwide, from 51.0% in the Southeast to as low as 21.0% in the North. The Family Health Strategy was implemented in most units (61.0%); however, they did not offer more health promotion programs than others did. CONCLUSIONS Our study showed that most primary care units have in place health promotion programs. Public policies are needed to strengthen primary care services and improve training of health providers to meet the goals of the agenda for health promotion in Brazil.OBJETIVO Estimar a prevalência de programas de promoção da saúde nas unidades básicas de saúde no Brasil. MÉTODOS Estudo transversal descritivo realizado por meio de entrevistas telefônicas com coordenadores de unidades básicas de saúde. Do total de 42.486 unidades básicas de saúde cadastradas pelo Ministério da Saúde, 1.600 foram aleatoriamente selecionadas. As unidades foram amostradas nas cinco regiões do País de acordo com a proporção de unidades em cada região. Foi analisada a presença ou não de cinco programas de promoção da saúde: promoção de atividade física, cessação de tabagismo, cessação de uso de álcool e drogas ilícitas, alimentação saudável e ambiente saudável. Foram coletados dados sobre o tipo de ações desenvolvidas nos programas e a presença ou não da Estratégia de Saúde da Família na unidade. RESULTADOS A maioria das unidades básicas de saúde (62,0%) referiu ter pelo menos três programas de promoção da saúde e apenas 3,0% não tinha nenhum. A promoção do ambiente saudável e da alimentação saudável foram os programas mais prevalentes (77,0% e 72,0%, respectivamente), enquanto o controle do tabaco e do álcool foram referidos em 54,0% e 42,0% das unidades de saúde, respectivamente. A promoção de atividade física foi referida em menos de 40,0% das unidades e teve grande variação regional, com prevalência de 51,0% nas unidades do Sudeste e apenas 21,0% nas do Norte. A maioria das unidades de saúde (61,0%) oferecia Estratégia de Saúde da Família, porém não foi verificada maior prevalência de programas de promoção da saúde nessas unidades em relação às outras. CONCLUSÕES Este estudo mostrou que programas de promoção da saúde estão presentes na maioria das unidades básicas de saúde. Políticas públicas devem fortalecer a infraestrutura das unidades básicas de saúde e melhorar a capacitação dos trabalhadores de saúde para executar adequadamente a agenda de promoção de saúde do governo brasileiro