ACTION OF CHLORAMPHENICOL ON T-1 BACTERIOPHAGE I. : Inhibition of Intracellular Multiplication

The complex sequence of events following in-fection of a susceptible bacterium with a bac-teriophage which results in the formation of new virus is being elucidated gradually through the application of widely divergent techniques. How-ever, despite the increasing knowledge concern-ing such matters, many basic questions remain unanswered. Foremost among these is the ques-tion of the biochemical mechnim involved in the redirection of metabolic processes in the in-fected cell toward virus production. The present study presents a tool which may be useful for investigations along these lines. The antibiotic, chloramphenicol, has been shown to inhibit strongly the synthesis of bac