66 research outputs found
Statistical strategies for avoiding false discoveries in metabolomics and related experiments
Full text linkRecommended from our members
Catalytic activity of nuclease P1: Experiment and theory
No full textNuclease P1 from Penicillium citrinum is a zinc dependent glyco-enzyme that recognizes single stranded DNA and RNA as substrates and hydrolyzes the phosphate ester bond. Nuclease Pl seems to recognize particular conformations of the phosphodiester backbone and shows significant variation in the rate of hydrolytic activity depending upon which nucleosides are coupled by the phosphodiester bond. The efficiency of nuclease Pl in hydrolyzing the phosphodiester bonds of a substrate can be altered by modifications to one of the substrate bases induced by ionizing radiation or oxidative stress. Measurements have been made of the effect of several radiation induced lesions on the catalytic rate of nuclease Pl. A model of the structure of the enzyme has been constructed in order to better understand the binding and activity of this enzyme on various ssDNA substrates
The automatic design of fractional factorial experiments for adaptive process optimization
No full textAn E.S.R. Study of Stable Radicals in Gamma-irradiated Single Crystals of Uridine 5′-phosphate (Na Salt)
No full text
Quantifying Uncertainty in Statistical Distribution of Small Sample Data Using Bayesian Inference of Unbounded Johnson Distribution
No full text
- …
