Innovations in pediatric drug formulations and administration technologies for low resource settings

© 2019 by the authors. Licensee MDPI, Basel, Switzerland. Despite advances in regulations and initiatives to increase pediatric medicine development, there is still an unmet need for age-appropriate medicines for children. The availability of pediatric formulations is particularly lacking in resource poor areas, due to, for example, area-specific disease burden and financial constraints, as well as disconnected supply chains and fragmented healthcare systems. The paucity of authorized pediatric medicines often results in the manipulation and administration of products intended for adults, with an increased risk of mis-dosing and adverse reactions. This article provides an overview of the some of the key difficulties associated with the development of pediatric medicines in both high and low resource areas, and highlights shared and location specific challenges and opportunities. The utilization of dispersible oral dosage forms and suppositories for low and middle-income countries (LMICs) are described in addition to other platform technologies that may in the future offer opportunities for future pediatric medicine development for low resource settings

Extended polarized semiclassical model for quantum-dot cavity QED and its application to single-photon sources

We present a simple extension of the semi-classical model for a two-level system in a cavity, in order to incorporate multiple polarized transitions, such as those appearing in neutral and charged quantum dots (QDs), and two nondegenerate linearly polarized cavity modes. We verify the model by exact quantum master equation calculations, and experimentally using a neutral QD in a polarization non-degenerate micro-cavity, in both cases we observe excellent agreement. Finally, the usefulness of this approach is demonstrated by optimizing a single-photon source based on polarization postselection, where we find an increase in the brightness for optimal polarization conditions as predicted by the model.Comment: 8 pages, for simple code see https://doi.org/10.5281/zenodo.347666

A systematic review of tagging as a method to reduce theft in retail environments

Background: Retailers routinely use security tags to reduce theft. Presently, however, there has been no attempt to systematically review the literature on security tags. Guided by the acronym EMMIE, this paper set out to (1) examine the evidence that tags are effective at reducing theft, (2) identify the key mechanisms through which tags are expected to reduce theft and the conditions that moderate tag effectiveness, and (3) summarise information relevant to the implementation and economic costs of tagging. Methods: In this mixed-methods review, we performed systematic keyword searches of the published and unpublished literature, hand searched relevant journals, conducted forward and backward citation searches and consulted with four retailers. Studies were included if they reported an explicit goal of reducing the theft or shrinkage of items through the use of security tags in retail environments. Results: We identified 50 eligible studies, eight of which reported quantitative data on the effectiveness of tags in retail environments. Across these eight studies, five showed positive results associated with the introduction of tags, but heterogeneity in the type of tag and reported outcome measures precluded a meta-analysis. We identified three mechanisms through which tags might plausibly reduce theft-increase the risks, reduce the rewards, increase the effort-which were found to vary by tag type, and their activation dependent on five broad categories of moderator: retail store and staff, customers (including shoplifters), tag type, product type, and the involvement of the police and criminal justice system. Implementation challenges documented in the literature related mainly to staffing issues and tagging strategy. Finally, although estimates are available on the costs of tagging, our searches identified no highquality published economic evaluations of tagging. Conclusions: Through applying the EMMIE framework this review highlighted the complexity involved in security tagging in retail environments, whereby different kinds of tags are expected to reduce theft through different casual mechanisms which are dependent on a distinctive configuration of conditions. Based on the available evidence it is difficult to determine the effectiveness of tags as a theft reduction measure, albeit there is suggestive evidence that more visible tags are associated with greater reductions in theft than less visible tags

Uniformity of V minus Near Infrared Color Evolution of Type Ia Supernovae, and Implications for Host Galaxy Extinction Determination

From an analysis of SNe 1972E, 1980N, 1981B, 1981D, 1983R, 1998bu, 1999cl, and 1999cp we find that the intrinsic V-K colors of Type Ia SNe with multi-color light curve shape (MLCS) parameter -0.4 < Delta < +0.2 suggest a uniform color curve. V-K colors become bluer linearly with time from roughly one week before B-band maximum until one week after maximum, after which they redden linearly until four weeks after maximum. V-H colors exhibit very similar color evolution. V-J colors exhibit slightly more complex evolution, with greater scatter. The existence of V minus near infrared color relations allows the construction of near infrared light curve templates that are an improvement on those of Elias et al. (1985). We provide optical BVRI and infrared JHK photometry of the Type Ia supernovae 1999aa, 1999cl, and 1999cp. SN 1999aa is an overluminous "slow decliner" (with Delta = -0.47 mag). SN 1999cp is a moderately bright SN unreddened in its host. SN 1999cl is extremely reddened in its host. The V minus near infrared colors of SN 1999cl yield A_V = 2.01 +/- 0.11 mag. This leads to a distance for its host galaxy (M 88) in agreement with other distance measurements for members of the Virgo cluster.Comment: 57 pages, 13 postscript figures, to appear in the August 20, 2000, issue of the Astrophysical Journal. Contains updated references and a number of minor corrections dealt with when page proofs were correcte

Generation of highly ionized cadmium plasma columns for a discharge-pumped Nickel-like Cd laser

Includes bibliographical references (page 574).We report the observation of strong line emission from Ni-like Cd ions in a capillary discharge plasma. Spectroscopically pure Cd vapor was produced in a room temperature environment utilizing a capacitive discharge. The metal vapor was injected into a capillary channel where it was subsequently excited with fast current pulses of up to 200 kA These results open the possibility of observing laser amplification in the 3d94d-394p line of Ni-like Cd at 13.2 nm and in laser lines of other Nickel-like ions in a discharge-created plasma

Discovery of Enhanced Germanium Abundances in Planetary Nebulae with FUSE

We report the discovery of Ge III $\lambda$1088.46 in the planetary nebulae (PNe) SwSt 1, BD+30$^{\rm o}$3639, NGC 3132, and IC 4593, observed with the Far Ultraviolet Spectroscopic Explorer. This is the first astronomical detection of this line and the first measurement of Ge (Z = 32) in PNe. We estimate Ge abundances using S and Fe as reference elements, for a range of assumptions about gas-phase depletions. The results indicate that Ge, which is synthesized in the initial steps of the s-process and therefore can be self-enriched in PNe, is enhanced by factors of > 3-10. The strongest evidence for enrichment is seen for PNe with Wolf-Rayet central stars, which are likely to contain heavily processed material.Comment: 11 pages, 1 figure, accepted for publication in ApJ Letter

University of Minnesota – Twin Cities Modifications to the Montana State University Telemetry System for Stratospheric Eclipse Ballooning

On August 21, 2017, the path of totality of a solar eclipse swept across the continental United States from Oregon to South Carolina. Our team, flying weather balloons near Grand Island, Nebraska, was able to live stream the shadow of the moon from the stratosphere to the ground. The team was able to track our balloons with high accuracy due to new payload software and hardware implemented on the still image telemetry platform developed by the Montana Space Grant. In addition, the modified system allowed the team to relay commands and receive information from individual payloads attached to our balloons, giving live telemetry and control from a new GUI-based ground station control application. Although the eclipse is now over, the system will still be a powerful and useful tool for the University of Minnesota stratospheric ballooning team. The platform could be used for any other application needing real-time, ground-based communication to various payloads on a balloon gondola

Morale is high in acute inpatient psychiatry

Background: Morale on acute psychiatric wards has been considered to be problematic, and is reported to contribute to low quality patient care. Aim: To assess the relationship of staff morale to patient, service environment, physical environment, patient routines, conflict, containment, staff demographics, and staff group variables. Method: A multivariate cross sectional study was undertaken collecting data on morale and other variables on 136 acute admission psychiatric wards in England. Results: Morale was higher than published comparison samples. Length of time in post was correlated with low morale, and qualified nurses had higher emotional exhaustion but also higher personal accomplishment. The level of verbal abuse on a ward was associated with low morale, as was a higher level of social deprivation among patients. Higher levels of order and organisation correlated with better morale. Conclusions: Clear policies relating to the management of verbal abuse by patients, high levels of order and organisation, and staff rotation and education, may all support high morale. Acute inpatient psychiatry is generally a happy and rewarding work environment, and identified problems are likely to be due to other factors

A Sub-Picojoule per Bit Integrated Magneto-Optic Modulator on Silicon: Modeling and Experimental Demonstration

Integrated magneto-optic (MO) modulators are an attractive but not fully explored alternative to electro-optic (EO) modulators. They are current driven, structurally simple, and could potentially achieve high efficiency in cryogenic and room temperature environments where fJ bit−1 optical interfaces are needed. In this paper, the performance and energy efficiency of a novel MO modulator at room temperature are for the first time assessed. First, a model of the micro-ring-based modulator is implemented to investigate the design parameters and their influence on the performance. Then, a fabricated device is experimentally characterized to assess its performance in terms of bit rate and energy efficiency. The model shows efficient operation at 1.2 Gbps using a 16 mA drive current, consuming only 155 fJ bit−1. The experimental results show that the MO effect is suitable for modulation, achieving error-free operation above 16 mA with a power consumption of 258 fJ bit−1 at a transient limited data rate of 1.2 Gbps