Phonological restrictions on nominal pluralization in Sign Language of the Netherlands: evidence from corpus and elicited data

This study focuses on nominal pluralization in Sign Language of the Netherlands (NGT). The aim is to offer a comprehensive description of nominal pluralization processes in the language, based on both corpus data and elicited data, taking into account potential phonological restrictions. The results reveal that NGT nouns can undergo several pluralization processes, the main ones being simple reduplication (i.e., repeating the noun sign at one location) and sideward reduplication (i.e., repeating the noun sign while moving the hand sideward). The choice of pluralization process depends on phonological properties of the base noun: (i) nouns that are body-anchored or involve a complex movement undergo simple reduplication; (ii) nouns articulated at the lateral side of the signing space undergo sideward reduplication; (iii) nouns articulated on the midsagittal plane can undergo both simple and sideward reduplication. Strikingly, the data show considerable variation, and all types of nouns can be zero-marked, that is, plural marking on the noun is not obligatory. The results further suggest that all nouns can undergo at least one type of reduplication. Thus, while phonological properties of the base noun influence the type of reduplication, they do not block reduplication altogether. Plural reduplication in NGT is therefore less constrained than has been reported for other sign languages, where certain noun types cannot undergo reduplication. This shows that reduplication – despite being iconically motivated – is subject to language-specific grammatical constraints

THROUGH as a free aspect marker in Sign Language of the Netherlands

This study presents a descriptive analysis of the aspectual particle THROUGH in Sign Language of the Netherlands, based on naturalistic corpus data. The results show that THROUGH marks both continuative and habitual aspect on a wide range of lexical verbs, and can appear in varying syntactic positions (i.e., both following and preceding the main verb). These results challenge previous observations by Hoiting & Slobin (2001), who argued that THROUGH only marks aspect on lexical verbs when phonological features of the verb block aspectual modification, and that it is restricted to the syntactic position immediately following the main verb. In our data THROUGH appears to be less restricted than their analysis suggests. Further, the present study challenges the results in Oomen (2016), who found that THROUGH did not occur in her data. Finally, in the corpus data, THROUGH sometimes appears without a lexical main verb, a pattern that was not attested in previous studies. In some sentences, this is due to ellipsis of the main verb, while for others, in which THROUGH seems to function as a lexical verb itself, it will be argued that THROUGH might be in the process of degrammaticalization

Nominal plurals in Sign Language of the Netherlands: Accounting for allomorphy and variation

n both signed and spoken languages, reduplication is a common process in the formation of morphologically complex structures, expressing, e.g., plurality and certain aspectual meanings. A framework in which spoken language reduplication has been formalized frequently is Optimality Theory (OT). While an important attribute of OT-constraints is their universality, to date, the question to what extent such constraints are modality-independent, and thus work for sign language reduplication as well, remains largely unanswered. In the present study, we offer the first OT-formalization of plural reduplication in Sign Language of the Netherlands (NGT). The NGT-data reveal that this language features different plural allomorphs, the choice of which depends on phonological properties of the base noun. However, we also identify variation, e.g., all noun types allow for zero marking.In our formalization, we aim to introduce constraints that are maximally modality-independent, using constraint types that have previously been proposed for spoken language reduplication. Our formalization is the first to take into account base-reduplicant faithfulness for a sign language, and also the first to account for variation in sign language data by employing stochastic OT, whereby some noise is added to the ranking value of each constraint at evaluation time. Evaluating the modality-(in)dependence of our proposed account suggests that the types of constraints we employ as well as the evaluation in the spirit of stochastic OT are not specific to a modality, while the featural implementation is inevitably modality-dependent

The influence of the schedule and the dose of gemcitabine on the anti-tumour efficacy in experimental human cancer.

The therapeutic efficacy of gemcitabine, a new nucleoside analogue, was assessed in a variety of well-established human soft tissue sarcoma and ovarian cancer xenografts grown s.c. in nude mice. Tumour lines selected had different histological subtypes, growth rates and sensitivities to conventional cytostatic agents. The three different doses and schedules designed on the basis of a mean weight loss between 5% and 15% were i.p. injections of daily 3.5 mg kg-1 x 4, every 3 days 120 mg kg-1 x 4, and weekly 240 mg kg-1 x 2, which ultimately resulted in 19%, 10% and 4% toxic deaths, respectively. The weekly schedule induced > or = 50% growth inhibition in 2/4 soft tissue sarcoma and 4/6 ovarian cancer lines, while in three ovarian cancer lines > or = 75% growth inhibition was obtained. The anti-tumour effects of gemcitabine appeared to be similar or even better than previous data with conventional drugs tested in the same tumour lines. In comparison with the every 3 days schedule, the weekly and the daily schedule were less effective in 5/7 and 3/3 tumour lines (P < 0.001), respectively. In another experiment in three human tumour lines selected for their differential sensitivity to gemcitabine, weekly injections of 240 mg kg-1 x 6 did not result in a significant increase in the percentages of growth inhibition when compared to lower doses of 120 mg kg-1 or 60 mg kg-1 in the same schedule. However, the 240 mg kg-1 weekly x 6 schedule showed superior effects in 2/3 tumour lines in comparison with the same dose given every 2 weeks x 3 (P < 0.05). The preclinical activity of gemcitabine suggests that the drug can induce responses in soft tissue sarcoma and ovarian cancer patients. Our results further indicate that clinical trials of gemcitabine in solid tumour types should be designed on the basis of a schedule rather than a dose dependence

Empathy Gaps Between Helpers and Help-Seekers: Implications for Cooperation

Help-seekers and potential helpers often experience an “empathy gap” – an inability to understand each other’s unique perspectives. Both parties are concerned about their reputation, self-esteem, and relationships, but these concerns differ in ways that lead to misinterpretation of the other party’s actions, and, in turn, missed opportunities for cooperation. In this article, we review research that describes the role-specific concerns of helpers and help-seekers. We then review studies of emotional perspective-taking, which can help explain why help-seekers and helpers often experience empathy gaps. We go on to discuss recent work that illustrates the consequences of empathy gaps between helpers and help-seekers—social prediction errors that prevent helping and misguided intentions that can lead to unhelpful help. Finally, we discuss some promising directions for future research

Interventions to improve medication adherence in tuberculosis patients:A systematic review of randomized controlled studies

Non-adherence to anti-tuberculosis (anti-TB) medication is a major risk factor for poor treatment outcomes. We therefore assessed the effectiveness of medication adherence enhancing interventions in TB patients. We report a systematic review of randomized controlled trials that included either latent tuberculosis infection (LTBI) or active TB patients. Outcomes of interest included adherence rate, completed treatment, defaulted treatment and treatment outcomes. We identified four LTBI and ten active TB studies. In active TB patients, directly observed treatment (DOT) by trained community workers, short messaging service combined with education, counselling, monthly TB vouchers, drug box reminders and combinations of those were found effective. In LTBI patients, shorter regimens and DOT effectively improved treatment completion. Interestingly, DOT showed variable effectiveness, highlighting that implementation, population and setting may play important roles. Since non-adherence factors are patient-specific, personalized interventions are required to enhance the impact of a programme to improve medication adherence in TB patients