SU(3) Breaking in Hyperon Beta Decays: a Prediction for Xi^0 -> Sigma^+ e nu-bar

On the basis of a previous analysis of hyperon semi-leptonic decay data, a prediction is presented for g_1/f_1 in the Xi^0 -> Sigma^+ e nu-bar beta-decay. The analysis takes into account SU(3) breaking in this sector via the inclusion of mass-driven corrections. A rather precise measurement of the above channel by the KTeV experiment at Fermilab will shortly be available. Since the dependence on the SU(3) parameters, F and D, is identical to that of the neutron beta-decay, such a measurement will provide a rather stringent test of SU(3) and the models used to describe its violation in these decays. The prediction given here for the above decay is g_1/f_1=1.17, which leads to a rate of 0.80 x 10^6 s^-1 and thus a branching fraction of 2.3 x 10^-4.Comment: LaTeX, 7 pages, uses acromake, cite and topcapt packages. Non-printing extended ascii characters replaced plus minor correction

Isospin Breaking in Neutron β\beta-decay and SU(3) Violation in Semi-leptonic Hyperon Decays

Present precision measurements of the neutron life time lead to a CKM matrix element $|V_{ud}|$ which is three standard deviations off the value inferred from heavy quark decays etc. We investigate the possibility whether isospin-breaking effects in the neutron-to-proton vector current transition matrix element $=1+\delta g_V$ could eventually close this gap. For that we calculate in chiral perturbation theory the effect of pion and kaon loops on the matrix element $$ taking into account the mass differences of the charged and neutral mesons. We find a negligibly small isospin-breaking effect of $\delta g_V \simeq -4 \cdot 10^{-5}$. The crucial quantity in the analysis of neutron beta-decay precision measurements is thus the radiative correction term $\Delta_R$. Furthermore, we calculate in heavy baryon chiral perturbation theory the SU(3) breaking effects on the vector transition charges of weak semi-leptonic hyperon decays. We find for these quantities channel-dependent relative deviations from the SU(3) limit which range from -10% to $+1$.Comment: 6 pages, 1 figure, to be published in Physical Review C (brief report

Chiral corrections to kaon-nucleon scattering lengths

We calculate the threshold T-matrices of kaon-nucleon and antikaon-nucleon scattering to one loop order in SU(3) heavy baryon chiral perturbation theory. To that order the complex-valued isospin-1 $\bar KN$ threshold T-matrix can be successfully predicted from the isospin-0 and 1 $KN$ threshold T-matrices. As expected perturbation theory fails to explain the isospin-0 $\bar KN$ threshold T-matrix which is completely dominated by the nearby subthreshold $\Lambda^*(1405)$-resonance. Cancelations of large terms of second and third chiral order are observed as they seem to be typical for SU(3) baryon chiral perturbation theory calculations. We also give the kaon and eta loop corrections to the $\pi N$ scattering lengths and we investigate $\pi\Lambda$ scattering to one-loop order. The second order s-wave low-energy constants are all of natural size and do not exceed 1 GeV$^{-1}$ in magnitude.Comment: 8 pages, 2 figures, published in Phys. Rev. C64, 045204 (2001), corrections of numerical prefactors in Eqs.(10,11,12

Sea Contributions and Nucleon Structure

We suggest a general formalism to treat a baryon as a composite system of three quarks and a `sea'. In this formalism, the sea is a cluster which can consists of gluons and quark-antiquark pairs. The hadron wave function with a sea component is given. The magnetic moments, related sum rules and axial weak coupling constants are obtained. The data seems to favor a vector sea rather than a scalar sea. The quark spin distributions in the nucleon are also discussed.Comment: 24 page

A Proposed Test of Charge Symmetry in Σ\Sigma Decay

The semi-leptonic decays of $\Sigma^\pm$ offer a vehicle for observing charge symmetry-breaking. The effect is expected to be about 6\%, enhanced due to the replacement of two u quarks by d quarks. We propose that present experimental data be improved to search for this effect.Comment: 6 pages, submitted to Physical Review D, Brief Reports, Report # DOE/ER/40427-14-N9

Semileptonic decay constants of octet baryons in the chiral quark-soliton model

Based on the recent study of the magnetic moments and axial constants within the framework of the chiral quark-soliton model, we investigate the baryon semileptonic decay constants $(f_1,f_2)$ and $(g_1, g_2)$. Employing the relations between the diagonal transition matrix elements and off-diagonal ones in the vector and axial-vector channels, we obtain the ratios of baryon semileptonic decay constants $f_2/f_1$ and $g_1/f_1$. The $F/D$ ratio is also discussed and found that the value predicted by the present model naturally lies between that of the Skyrme model and that of the nonrelativistic quark model. The singlet axial constant $g^{(0)}_A$ can be expressed in terms of the $F/D$ ratio and $g^{(3)}_A$ in the present model and turns out to be small. The results are compared with available experimental data and found to be in good agreement with them. In addition, the induced pseudotensor coupling constants $g_2/f_1$ are calculated, the SU(3) symmetry breaking being considered. The results indicate that the effect of SU(3) symmetry breaking might play an important role for some decay modes in hyperon semileptonic decay.Comment: 16 pages, RevTeX is used. No figure. Accepted for publication in Phys. Rev.

Characteristics and outcome in patients with central nervous system involvement treated in European pediatric acute myeloid leukemia study groups

Background: There is no consensus on the treatment for pediatric patients with acute myeloid leukemia and initial central nervous system (CNS) involvement. Methods: To evaluate different CNS-directed treatment options (intrathecal [IT] therapy, CNS irradiation, hematopoietic stem cell transplantation [HSCT]), 261 patients (excluding acute promyelocytic leukemia) with initial CNS involvement treated in trials with similar intensive chemotherapy by four cooperative European study groups (1998–2013) were studied and compared with CNS-negative patients from the Berlin–Frankfurt–Münster group. Results: Patient characteristics in the different study groups were comparable. Young age, high white blood cell count, extramedullary involvement other than the CNS, monoblastic morphology, and inv(16) were associated with CNS involvement (each P < 0.0001). There were no major differences in outcome between the study groups. The cumulative incidence of relapse (CIR) regarding the CNS was higher in initially CNS-positive versus initially CNS-negative patients (all: 8 ± 2% vs. 3 ± 1%, P(Gray) = 0.001; isolated: 4 ± 1% vs. 1 ± 0%, P(Gray) = 0.03). However, global outcome of the CNS-positive cohort (overall survival, 64 ± 3%; event-free survival 48 ± 3%; and CIR 33% ± 3%) did not differ significantly from CNS-negative patients. Risk groups defined by cytogenetics were of likewise prognostic significance in CNS-positive and -negative patients. CNS treatment with cranial irradiation was not superior compared to IT therapy and systemic chemotherapy (± HSCT). Conclusion: Although CNS relapses occurred more frequently in initially CNS-positive patients, their global outcome was similar as in CNS-negative patients. Intensified IT therapy was heterogeneous; however, at least eight applications, preferably with triple IT chemotherapy, seem to be appropriate to accompany dose-intensive systemic chemotherapy

The GATA1s isoform is normally down-regulated during terminal haematopoietic differentiation and over-expression leads to failure to repress MYB, CCND2 and SKI during erythroid differentiation of K562 cells

Background: Although GATA1 is one of the most extensively studied haematopoietic transcription factors little is currently known about the physiological functions of its naturally occurring isoforms GATA1s and GATA1FL in humans—particularly whether the isoforms have distinct roles in different lineages and whether they have non-redundant roles in haematopoietic differentiation. As well as being of general interest to understanding of haematopoiesis, GATA1 isoform biology is important for children with Down syndrome associated acute megakaryoblastic leukaemia (DS-AMKL) where GATA1FL mutations are an essential driver for disease pathogenesis. <p/>Methods: Human primary cells and cell lines were analyzed using GATA1 isoform specific PCR. K562 cells expressing GATA1s or GATA1FL transgenes were used to model the effects of the two isoforms on in vitro haematopoietic differentiation. <p/>Results: We found no evidence for lineage specific use of GATA1 isoforms; however GATA1s transcripts, but not GATA1FL transcripts, are down-regulated during in vitro induction of terminal megakaryocytic and erythroid differentiation in the cell line K562. In addition, transgenic K562-GATA1s and K562-GATA1FL cells have distinct gene expression profiles both in steady state and during terminal erythroid differentiation, with GATA1s expression characterised by lack of repression of MYB, CCND2 and SKI. <p/>Conclusions: These findings support the theory that the GATA1s isoform plays a role in the maintenance of proliferative multipotent megakaryocyte-erythroid precursor cells and must be down-regulated prior to terminal differentiation. In addition our data suggest that SKI may be a potential therapeutic target for the treatment of children with DS-AMKL

Right Handed Weak Currents in Sum Rules for Axialvector Constant Renormalization

The recent experimental results on deep inelastic polarized lepton scattering off proton, deuteron and $^{3}$He together with polari% zed neutron $\beta$-decay data are analyzed. It is shown that the problem of Ellis-Jaffe and Bjorken sum rules deficiency and the neutron paradox could be solved simultaneously by assuming the small right handed current (RHC) admixture in the weak interaction Lagrangian. The possible RHC impact on pion-nucleon $\sigma$-term and Gamow-Teller sum rule for $(p,n)$ nuclear reactions is pointed out.Comment: to be published in Phys. Rev. Lett. LaTeX, 8 pages, 21 k