Adjustment and income distribution : a counterfactual analysis

This paper presents model simulations to quantify the effects of different stabilization packages in the distribution of income and wealth. The simulations suggest that a sharply contractionary stabilization package has a major adverse impact on the distribution of income. The shifts in distribution are likely to make the package less sustainable. The simulations support the view that stabilization packages which do not have specific components targeted to the poor will redistribute income in a way that, although transitory, is likely to permanently harm those below the poverty line - in terms of things like nutrition, health, and education. The sharp redistributive effects of stabilization packages that omit specific targeted policies to alleviate poverty are also likely to endanger the sustainability of the adjustment package.Economic Theory&Research,Environmental Economics&Policies,Economic Stabilization,Banks&Banking Reform,Inequality

An EM algorithm for estimation in the Mixture Transition Distribution model

The Mixture Transition Distribution (MTD) model was introduced by Raftery to face the need for parsimony in the modeling of high-order Markov chains in discrete time. The particularity of this model comes from the fact that the effect of each lag upon the present is considered separately and additively, so that the number of parameters required is drastically reduced. However, the efficiency for the MTD parameter estimations proposed up to date still remains problematic on account of the large number of constraints on the parameters. In this paper, an iterative procedure, commonly known as Expectation-Maximization (EM) algorithm, is developed cooperating with the principle of Maximum Likelihood Estimation (MLE) to estimate the MTD parameters. Some applications of modeling MTD show the proposed EM algorithm is easier to be used than the algorithm developed by Berchtold. Moreover, the EM Estimations of parameters for high-order MTD models led on DNA sequences outperform the corresponding fully parametrized Markov chain in terms of Bayesian Information Criterion. A software implementation of our algorithm is available in the library seq++ at http://stat.genopole.cnrs.fr/seqppComment: 22 page

Konstruktion och undersökelse, exotism och närhet i Per Olof Sundmans böker om Lofoten

The Swedish writer Per Olof Sundman (1922-1992) wrote mostly short stories and novels, but also reportages. The paper deals with two reportages from the Lofoten islands, Människor vid hav (1966, “People by the sea”) and Lofoten, sommar (1973, “Lofoten, summer”) The choice of the Lofoten islands as a subject is related to a fascination Sundman felt towards northern and arctic regions, a fascination he also expressed in a number of fictional narratives and in the documentary novel Ingenjör Andrées luftfärd (1967. English title: The Flight of the Eagle) A question that arises almost immediately is whether that fascination affects the way the reporter works and how it affects it. How does Sundman look at the Lofoten? What does he take notice of and tell us about? What kind of image does he give? And how does he understand his own role, his function as an investigator in an environment which is neither his own nor his postulated readers’ usual environment? Another question deals with the relationship between the reportages from the Lofoten and the author’s other works. Are the reportages easy to recognize as Sundmanian texts, can Sundman’s “signature” be traced in them? It appears that “People by the sea” and “Lofoten, summer” are not merely informative texts. They also to a rather high degree suggest an atmosphere, using among other things inherited representations and judgements to that purpose. Those reportages turn out to be strongly literary texts, in the traditional meaning of the word

Psychoneuroimmunology and stress responses in HIV 1 seropositive and at risk gay men

https://nsuworks.nova.edu/hpd_com_facbooks/1017/thumbnail.jp

CFTR channel insertion to the apical surface in rat duodenal villus epithelial cells is upregulated by VIP in vivo

cAMP activated insertion of the cystic fibrosis transmembrane conductance regulator (CFTR) channels from endosomes to the apical plasma membrane has been hypothesized to regulate surface expression and CFTR function although the physiologic relevance of this remains unclear. We previously identified a subpopulation of small intestinal villus epithelial cells or CFTR high expressor (CHE) cells possessing very high levels of apical membrane CFTR in association with a prominent subapical vesicular pool of CFTR. We have examined the subcellular redistribution of CFTR in duodenal CHE cells in vivo in response to the cAMP activated secretagogue vasoactive intestinal peptide (VIP). Using anti-CFTR antibodies against the C terminus of rodent CFTR and indirect immunofluorescence, we show by quantitative confocal microscopy that CFTR rapidly redistributes from the cytoplasm to the apical surface upon cAMP stimulation by VIP and returns to the cytoplasm upon removal of VIP stimulation of intracellular cAMP levels. Using ultrastructural and confocal immunofluorescence examination in the presence or absence of cycloheximide, we also show that redistribution was not dependent on new protein synthesis, changes in endocytosis, or rearrangement of the apical cytoskeleton. These observations suggest that physiologic cAMP activated apical membrane insertion and recycling of CFTR channels in normal CFTR expressing epithelia contributes to the in vivo regulation of CFTR mediated anion transport

Disruption of GnRH secretion in peripubertal female rat after early postnatal exposure to Bisphenol A and involvement of GPR151, a potential new GnRH regulator

peer reviewe