Sudden death in two patients with variant angina and apparently minimal fixed coronary stenoses

This report deals with two patients suffering from typical variant angina in whom sudden death occurred 13 and 7 months respectively after coronary angiograms which demonstrated apparently minimal coronary stenoses. These cases illustrate possible mechanisms of sudden death in such patients including high degree AV block and ventricular tachyarrhythmias

QT interval measurement by a computer assisted program: A potentially useful clinical parameter

The duration of electrical systole (QT interval) was measured in 72 subjects (48 women and 24 men) who had normal coronary arteries and left ventricular function at cardiac catheterization (group 1). The same measurements were obtained in 100 patients with a normal ECG (from 40 women and 60 men referred to our institution and found normal on noninvasive clinical basis) and compared to a double independent manual calculation (group 2). The computer assisted program was found in reliable in QT interval measurements. In both study groups women showed longer QTc. No difference in QTc duration was seen in subjects taking β-blockers prior to angiography. As compared to group 1, subjects of group 2 showed similar average QTc values. However, 9 out of 100 subjects of group 2 had abnormal QTc as compared with none of group 1 (p<0.05). QTc calculations may improve the usefulness of computer assisted programs in ECG interpretation. Present data can be used as reference values for normality. They stress in addition the necessity of introducing the heart rate correction for the interpretation of QT interval. This can help in stimulating prospective clinical studies to assess the value of QTc as an index of risk for cardiac dysrhythmias