5 research outputs found
A prospective randomized comparison between small bowel enteroclysis and small bowel follow-through in Crohn's disease
The Dunedin Volcanic Group and a revised model for Zealandia's alkaline intraplate volcanism
Trace element mobility, regional significance and global implication of Gomati river basin, northern India
Iron and Cancer: More Ore To Be Mined
Iron is an essential nutrient that facilitates cell proliferation and growth. However, iron also has the capacity to engage in redox cycling and free radical formation. Therefore, iron can contribute to both tumour initiation and tumour growth; recent work has also shown that iron has a role in the tumour microenvironment and in metastasis. Pathways of iron acquisition, efflux, storage and regulation are all perturbed in cancer, suggesting that reprogramming of iron metabolism is a central aspect of tumour cell survival. Signalling through hypoxia-inducible factor (HIF) and WNT pathways may contribute to altered iron metabolism in cancer. Targeting iron metabolic pathways may provide new tools for cancer prognosis and therapy