Monomeric and dimeric copper (II) complexes based on bidentate Nʹ-(propan-2-ylidene) thiophene carbohydrazide Schiff base ligand: Synthesis, structure, magnetic properties, antioxidant and anti-Alzheimer activities

International audienceThe present study deals with the synthesis and characterization by single-crystal X-ray analysis and IR spectroscopy of two new Copper (II) complexes with bidentate Schiff base ligand [N'-(propan-2-ylidene) thiophene-2-carbohydrazide] (HL). Depending on the copper salt used in the synthesis, a mononuclear or doubly chloro bridged dinuclear Copper (II) complexes of respective formula [Cu(L) 2 ] (1) and [Cu 2 (μ-Cl) 2 (HL) 2 Cl 2 ] (2) have been obtained. Magnetic study of complex 2 indicates the presence of weak antiferromagnetic interactions between the metal centers. To determine the antioxidant properties of both complexes, the ABTS radical scavenging and the reduction of copper (II)-neocuproine [Cu(II)-Nc] (CUPRAC) methods were used; 1 was more efficient than 2, for the two antioxidants assays. Lastly, Anti AChE activity method has been used to estimate in vitro anti-Alzheimer effect of 1 and 2 both of which show a potent AChE inhibition