7 research outputs found
Elevation of Ligand Binding to Muscarinic M 2
- Author
- Publication venue
- 'American Chemical Society (ACS)'
- Publication date
- Field of study
Conformational Analysis, Molecular Shape Comparison, and Pharmacophore Identification of Different Allosteric Modulators of Muscarinic Receptors §
- Author
- Publication venue
- 'American Chemical Society (ACS)'
- Publication date
- Field of study
Synthesis of 4-Substituted Phthalazin-1(2 H
- Author
- Andrew M. Clausen
- Asselin S. M.
- Bernard A. M.
- Bethune R. J.
- Botero Cid H. M.
- Demirayak S.
- Desai A. C.
- Epsztajn J.
- Fiori J. M.
- Hemdan M. M.
- Hemdan M. M.
- Ishikawa M.
- Kaila N.
- Karl B. Hansen
- Kelly A. Nadeau
- Knott E. B.
- Kolkmann R.
- Kuznetsov V. A.
- L. Steven Hollis
- Lim C. J.
- Matthew M. Bio
- Melody L. Mak-Jurkauskas
- Morgan D. O.
- Pal M.
- Payton M.
- Raposo M. M. M.
- Robinson D. I.
- Scheffler G.
- Shubin K. M.
- Sloan K. B.
- Snodin D. J.
- Steven M. Mennen
- Sun M.
- Van der Mey M.
- Van der Mey M.
- Viña D.
- Yamada T.
- Yamada T.
- Yamaguchi M.
- Yamaguchi M.
- Yamaguchi M.
- Zogg A.
- Publication venue
- 'American Chemical Society (ACS)'
- Publication date
- Field of study
Mapping Property Distributions of Molecular Surfaces: Algorithm and Evaluation of a Novel 3D Quantitative Structure−Activity Relationship Technique
- Author
- Adamson G. W.
- Baroni M.
- Baumann K
- Baumann K
- Baumann K.
- Baumann K.
- Baumann K.
- Bender W.
- Botero Cid H. M.
- Broto P.
- Brown R. D.
- Burman P
- Carhart R. E.
- Christopher J. A.
- Coats E. A
- Connolly M. L.
- Cramer R. D.
- Cruciani G.
- Davis A. M.
- Doweyko A. M
- Draize J. H.
- Ferguson A. M.
- Gancia E.
- Geisser S
- Ghose A. K.
- Glover F
- Glover F.
- Goodford P. J
- Heiden W.
- Holzgrabe U.
- Hopfinger A. J.
- Howard J. A. K.
- Kennard R. W.
- Kier L. B.
- Klebe G.
- Klopman G.
- Kulkarni A.
- Mason J. S.
- McGregor M. J.
- McKarns S. C.
- Mohr K.
- Moreau G.
- Nassif-Makki T.
- Osten D. W
- Pascual-Ahuir J. L.
- Pastor M.
- Rocchia W.
- Roecker E. B
- Rohrbough R. H.
- Sadowski J.
- Sanner M. F.
- Schur J. H.
- Shao J
- Sheridan R. P.
- Silverman B. D.
- Soltzberg L. J.
- Staudt M.
- SYBYL
- Todeschini R.
- Todeschini R.
- Topliss J. G.
- Tränkle C.
- UNITY
- Voss S.
- Wu W.
- Zhang P
- Zupan J.
- Publication venue
- 'American Chemical Society (ACS)'
- Publication date
- Field of study
ALLOSTERIC INTERACTIONS AT MUSCARINIC CHOLINOCEPTORS
- Author
- Bejeuhr G
- Bejeuhr G
- Birdsall NJM
- Birdsall NJM
- Botero Cid MH
- Brunner F
- Christopoulos A
- Christopoulos A
- Christopoulos A
- Christopoulos A
- Christopoulos A
- Clark AL
- Cohen‐Armon M
- Cohen‐Armon M
- Dunlap J
- Ehlert FJ
- Ehlert FJ
- Ellis J
- Ellis J
- Ellis J
- Ellis J
- Flynn DD
- Gerry RH
- Gerstin EH
- Gilani AH
- Giraldo E
- Hejnová L
- Hoare SRJ
- Hu J
- Hu J
- Jakubík J
- Jakubík J
- Jakubík J
- Jakubík J
- Jakubík J
- Jakubík J
- Jakubík J
- Kenakin T
- Kiefer‐Day JS
- Kostenis E
- Kostenis E
- Lanzafame A
- Lanzafame A
- Lazareno S
- Lee JH
- Lee NH
- Lee NH
- Lee NH
- Lee NH
- Lee NH
- Leppik RA
- Leung E
- Li CK
- Lüllmann H
- Maaβ A
- Maaβ A
- Matsui H
- Max SI
- Michel AD
- Mitchelson F
- Mohr K
- Mohr K
- Paton WDM
- Pearce BD
- Pedder EK
- Potter LT
- Prosˇka J
- Prosˇka J
- Prosˇka J
- Roeske WR
- Roffel AF
- Stockton JM
- Tränkle C
- Tränkle C
- Tränkle C
- Tucek S
- Tucek S
- Waelbroeck M
- Waelbroeck M
- Waelbroeck M
- Waelbroeck M
- Wang SZ
- Wess J
- Publication venue
- 'Wiley'
- Publication date
- Field of study
Host-microbe interactions in octocoral holobionts - recent advances and perspectives
- Author
- A Antonius
- A Apprill
- A Ata
- A Hernandez-Agreda
- A Meszaros
- A Pinzón-Espinosa
- A Zuluaga-Montero
- AM Tracy
- AMD ElAhwany
- AMS Correa
- AP Parrin
- AR Hannes
- AS Dmitrenok
- AS Kate
- AW Brooks
- AW Bruckner
- B Stobart
- BM Gudenkauf
- BW Chen
- C Alonso
- C Ascione
- C Cerrano
- C Ferrier-Pagès
- C Ferrier-Pagès
- C Pietschke
- C Prada
- C Prada
- C Rafel
- C Roder
- C Toledo-Hernández
- C Wilkinson
- C Yesson
- C-H Chao
- C-H Gao
- C-J Zheng
- C-Y Huang
- C-Y Kao
- C-Y Wang
- CA Burge
- CA Burge
- CA Kellogg
- CA Kellogg
- CA Ospina
- CD Pérez
- CS Couch
- CS McFadden
- CS McFadden
- CT Olano
- D Aurelle
- D Bourne
- D Dube
- D Forcioli
- D Harvell
- D Harvell
- D Harvell
- D Vafidis
- DE Morse
- DG Bourne
- DG Bourne
- DG Bourne
- DJ Gerhart
- DL Kirchman
- DM Baker
- DM Poland
- E Metchnikoff
- E Ransome
- E Rosenberg
- E Tello
- E Tello
- E Tello
- E Weil
- E Weil
- E Weil
- E Weil
- E Weil
- EA Lenz
- EC Franklin
- EC Kvennefors
- EMD Porporato
- EP McCauley
- EP McCauley
- F Houlbrèque
- F Le Roux
- FJ McEnroe
- G Baum
- G Erni Cassola
- G Torda
- GB Reinicke
- GC Williams
- GW Smith
- GW Smith
- H Correa
- H-M Oh
- HE Fox
- HH Wirshing
- I Hewson
- IA Beleneva
- II Rodríguez
- II Rodríguez
- J Frias-Lopez
- J Garrabou
- J Maynard
- J Rocha
- J-B Raina
- J-M Gili
- JA Sanchez
- JA Sánchez
- JA Sánchez
- JAJM van de Water
- JAJM van de Water
- JAJM van de Water
- JAJM van de Water
- JB Holm
- JK Harris
- JL Meyer
- JM Boehnlein
- JM Hall-Spencer
- JM Roberts
- JP Andras
- JR Leadbetter
- JR Ward
- JW Blunt
- K Kiho
- K Kim
- K Kim
- K Kim
- K Michalek
- K Penn
- KD Lafferty
- KD Weynberg
- KE Fabricius
- KH Sharp
- KH Sharp
- KL Asfahl
- KL Marhaver
- KM Morrow
- KM Morrow
- KP Shirur
- KP Sutherland
- KR Theis
- L Botero
- L Buhl-Mortensen
- L Muscatine
- L Reshef
- L Salter-Cid
- L Vezzulli
- LD Mydlarz
- LD Mydlarz
- LD Mydlarz
- LD Mydlarz
- LD Mydlarz
- LE Petes
- LG Tamar
- LJ Dishaw
- LP Menzel
- LR Hunt
- M Bally
- M Jimbo
- M La Rivière
- M La Rivière
- M McFall-Ngai
- M Pernice
- M Ribes
- M Rivière La
- M Slattery
- M Wakeford
- M Ziegler
- M Ziegler
- MA Gray
- MA Rashid
- ME Mouchka
- ME Skindersoe
- MH Uddin
- MI Vizcaino
- MJ Neave
- MJ Neave
- MJH Van Oppen
- MK Al-Zibdah
- MM Soler-Hurtado
- MT Schärer
- N Knowlton
- N Soffer
- NA Moran
- NL Douglas
- NL Forget
- NL Kirk
- NL Kirk
- NM Targett
- NS Webster
- P Katharios
- PA Farrant
- PR Jensen
- PW Sammarco
- R Berkelmans
- R Coma
- R Grover
- R Sekar
- RB Aronson
- RE Pike
- RR Ruzicka
- RS Peixoto
- RV Thurber
- S Cocito
- S Franzenburg
- S Franzenburg
- S Fraune
- S Fraune
- S Jensen
- S Morrison-Gardiner
- S Spring
- S Spring
- S Sunagawa
- S-L Wu
- S-Y Cheng
- S-Y Cheng
- SA Lawrence
- SA Look
- SC Neulinger
- SE Netherton
- SK FitzPatrick
- SN Lawler
- SP Ellner
- SS Porter
- ST Lin
- SY Cheng
- T Bayer
- T Bayer
- T Franco
- T Harder
- T Keller-Costa
- TB Brück
- TC Hoffmann
- TD Ainsworth
- TD Ainsworth
- TG Lilburn
- TL Colliver
- TL Goulet
- TL Goulet
- TL Goulet
- TM Pham
- TP Hughes
- TP Hughes
- TP Hughes
- UW Hawas
- V Pasquale
- V Robertson
- V Tilot
- VN Bednarz
- VN Bednarz
- VN Ivanenko
- W Nelson
- W Wessels
- WK Fitt
- WM Goldberg
- WT Mann
- X Wei
- X-Y Zhang
- Y Benayahu
- Y Benayahu
- Y Tomono
- Y Wang
- Y-S Lin
- ZH Wen
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Cardiac myosin activation with omecamtiv mecarbil in systolic heart failure
- Author
- A Alan Chu
- A Shekhar Pandey
- Aaron Sverdlov
- Abbasi S. A.
- Abdallah Al Mohammad
- Abdul Al-Hesayen
- Adams K. F.
- Adnan Malik
- Adriaan Voors
- Adrian Shandling
- Agata Marina Floresta
- Ahmet Celik
- Ailiman Mahemuti
- Aize van der Sluis
- Akihiro Koike
- Akihiro Nakamura
- Akihiro Terasawa
- Alan Gass
- Alan Kono
- Alan Meholick
- Alberto Caccavo
- Alberto Cadena Bonfanti
- Alberto Esteban Bazzoni Ruiz
- Alberto Fernandez
- Alberto Margonato
- Aldo Prado
- Alejandro Recio Mayoral
- Aleksander Wlodarczyk
- Aleksandra Manolova
- Alessandro Fucili
- Alex Mauricio Villablanca Sepulveda
- Alexander Adler
- Alexander Bykov
- Alexander Parkhomenko
- Alexander Sherenkov
- Alexander Timofeev
- Alexander Vishnevsky
- Alexandr Schee
- Alexandra Arias Mendoza
- Alexandre Tognon
- Alexey Repin
- Alicia Contreras Rodriguez
- Alina Giuca
- Alisdair Ryding
- Alistair Begg
- Almir Ferraz
- Alonzo Jones
- Amal Muthumala
- Aman Amanullah
- Amarinder Bindra
- Amin Karim
- Amin Yehya
- Amit Shah
- Amrut Ambardekar
- Ana Maria De Leon Flores
- Anand I.
- Anays Santana Izquierdo
- Andras Papp
- Andre Artis
- Andrea Mortara
- Andrej Dzupina
- Andres Iñiguez Romo
- Andrew Boyle
- Andrew Civitello
- Andrew Clark
- Andrew Coletti
- Andrew Hamilton
- Andrew Ludman
- Andrew Sauer
- Andrew Sindone
- Andriy Yagensky
- Andrzej Rynkiewicz
- Aniko Papp
- Anil Shah
- Anna Paszczuk
- Anna Stankiewicz
- Anselmo Paulino Bordonava
- Anthony Gemignani
- Anthony King
- Antonella Vincenzi
- Antonio Juan Castro Fernandez
- Antonio Lara Padron
- Apostolos Karavidas
- Arias-Mendoza A.
- Arif Elvan
- Arman Postadzhiyan
- Armando Garcia Castillo
- Arnold Seto
- Arthur Eberly 3rd
- Arun Krishnamoorthy
- Arunima Misra
- Assad Mouhaffel
- Assen Goudev
- Athanasios Manolis
- Atilio Costa-Vitali
- Atsushi Hirayama
- Atsutoshi Takagi
- Atsuyuki Wada
- Attila Mohacsi
- Aurelio Ortiz
- Aysha Badat
- Badrinathan Chandrasekaran
- Balgit Chhokar
- Barbara Pisani
- Barna Szabo
- Barry Bertolet
- Barry H Greenberg
- Barry Uretsky
- Batlagundu Lakshminarayanan
- Beat Knusel
- Beata Wozakowska-Kaplon
- Beatriz Diaz Molina
- Bela Herczeg
- Bela Merkely
- Benjamin Trichon
- Bhola Rama
- Biering-Sorensen T.
- Binoy Skaria
- Binu Jacob
- Bohm M.
- Bojidar Dimov
- Bonderman D.
- Boris Goloshchekin
- Bozena Sobkowicz
- Brack Hattler
- Bradley Weinberg
- Brenda Lemus
- Brenda Peart
- Brian Bostick
- Brian Claggett
- Brian Gordon
- Brian Houston
- Bruce Jackson
- Bruce Sussex
- Bruno Paolino
- Candida Fonseca
- Carl-Johan Lindholm
- Carlo Gabriele Tocchetti
- Carlos Alberto Luengas
- Carlos Arrieta Garcia
- Carlos Conejeros Kindel
- Carlos Poy
- Carmine De Pasquale
- Carol Davila
- Carsten Schmalfuss
- Celeste Williams
- Cesar Zaidman
- Cevat Kirma
- CezarEugen Macarie
- Changyong Zhou
- Charles Eaton
- Charles Koo
- Charles Lovell
- Charles Treasure
- Chavdar Velikov
- Chester Hedgepeth
- Chiara Melloni
- Chim Lang
- Christian Constance
- Christian Ebner
- Christian Mueller
- Christian Paolo Pincetti Jofre
- Christoph Kadel
- Christopher E Kurtz
- Christopher Judkins
- Christopher Lang
- Christopher Pickett
- Christopher Rowan
- Christopher Vaccari
- Christos Kassiotis
- Ciro Indolfi
- Claire Varin
- Clara Ines Saldarriaga Giraldo
- Claudia Raineri
- Claudio Bilato
- Claudio Cavallini
- Claudio Rodolfo Majul
- Cleland J. G. F.
- Coenraad van der Zwaan
- Constantin Militaru
- Corbalan R.
- Craig Barr
- Craig Hametz
- Crespo-Leiro M. G.
- Cristian Gheorghe Podoleanu
- Cristiano Pederneiras Jaeger
- Cristina Danila
- Csaba Salamon
- Dahlstrom U.
- Dalia Jarasuniene
- Dallas Price
- Dalton McLean
- Daniel Aradi
- Daniel Beug
- Daniel Fisher
- Daniel Gaudet
- Daniel Lenihan
- Daniel Lighezan
- Daniel Pauly
- Daniel Savard
- Daniel Vogel
- Daniela Garcia Brasca
- Daniela Pini
- Daniela Vinanska
- Dariusz Korczyk
- David Chang
- David F Kong
- David Henderson
- David Lanfear
- David Murray
- David Rawitscher
- David Schultz
- David Stepek
- David Whellan
- Debashis Roy
- Deddo Moertl
- Denis-Carl Phaneuf
- Dennis Rupka
- Deovrat Singh
- Devesh Patel
- Diana Bonderman
- Diaz R.
- Diego Alejandro Besada
- Diego Felipe Martinez
- Dimitrios Tziakas
- Dinesh Gupta
- Dipti Itchhaporia
- Dirk Boswijk
- Dirk Lok
- Dirk Schellings
- Dmitriy Belenkiy
- Dmitry Dronov
- Dmytro Reshotko
- Domenico Bonaduce
- Domingo Andres Pascual Figal
- Dongye Li
- Donna Mancini
- Dora Ines Molina de Salazar
- Douglas Brinkley
- Douglas Martel
- Douglas Sawyer
- Dragos Vinereanu
- Driek Beelen
- Dulce Brito
- Dumitru Zdrenghea
- Echeverria L. E.
- Edmundo Alfredo Bayram Llamas
- Edo Kaluski
- Eduardo Perna
- Eduardo Salcido Vazquez
- Edward Geltman
- Edward Portnay
- Egon Lenner
- Eileen O'Meara
- Einas Elmahi
- Eiran Gorodeski
- Elena Cowan
- Elena Kosmacheva
- Elena Kulibaba
- Elena Shutemova
- Ellis Lader
- Elvin Kedhi
- Erberto Carluccio
- Eric Decoulx
- Eric Klug
- Erik Hajko
- Ersel Onrat
- Ertugrul Okuyan
- Erwan Donal
- Eugene Chung
- Eugene Joseph Bauerlein
- Euler Roberto Fernandes Manenti
- Eva Goncalvesova
- Eva Peterfai
- Ewa Kalecinska-Krystkiewicz
- Ewa Straburzynska-Migaj
- Fabiana Rollini
- Fabio Silveira
- Fady I Malik
- Faiez Zannad
- Faisal Wahid
- Fang J. C.
- Farid Jadbabaie
- Felice Achilli
- Felix Ramires
- Feng Liu
- Ferenc Lakatos
- Fernando Bacal
- Fernando Boccalandro
- Fernando Colombo Berra
- Fernando Manzur Jattin
- Fernando Soto Loureiro
- Fernando Tomas Lanas Zanetti
- Filipa Almeida
- Filippatos G.
- Flavio Brito
- Flavio Eduardo Giorgeto
- Florence Rothenberg
- Florin Mitu
- Fonseca C.
- Fragkiskos Parthenakis
- Francesco Franchi
- Francisco Gonzalez Vilchez
- Francois Roubille
- Frank McGrew
- Frank Smart
- Frank Willems
- Franklin Handel
- François Picard
- Freny Mody
- Friedrich Fruhwald
- Fumi Yamamoto
- G Michael Felker
- Gabriel Arturo Ramos Lopez
- Gabriela Stanciulescu
- Gabriele Jakl-Kotauschek
- Gaetano Maria De Ferrari
- Garth Vaz
- Gary Yeoman
- Gaurav Aggarwala
- Georg Noll
- George Gabriel
- George Kochiadakis
- George Marzouka
- George Sokos
- Georgi Todorov
- Georgiy Dzyak
- Georgy Arbolishvili
- Gerardo Zapata
- Gerardus Linssen
- Gerasimos Filippatos
- Gerhard Poelzl
- Geza Lupkovics
- Giancarlo Piovaccari
- Gianfranco Sinagra
- Gianpiero Perna
- Gilmar Reis
- Gintare Sakalyte
- Giovanni Geronilla
- Giovanni Quinto Villani
- Giuseppe Ambrosio
- Giuseppe Musumeci
- Glenn Hamroff
- Goncalvesova E.
- Gordon Moe
- Gordon Reeves
- Goudev A. R.
- Gregorio Sanchez Vallejo
- Gregory Sampognaro
- Gregory Szto
- Gregory Thomas
- Grigorios Giamouzis
- Grzegorz Kania
- Grzegorz Skonieczny
- Guillaume De Geeter
- Guillaume Jondeau
- Guillermo Antonio Llamas Esperon
- Guoqin Chen
- Gurinder Grewal
- Gurusher Panjrath
- Gustavo Francisco Mendez Machado
- Guy Proulx
- Gyula Szasz
- Hakima Bourhaial
- Hal Skopicki
- Hamish Hart
- Hanbin Cui
- Hans Vandekerckhove
- Hans-Dirk Duengen
- Haralambos Karvounis
- Harinder Gogia
- Harukazu Iseki
- Hassan Ibrahim
- He Huang
- Heinz Drexel
- Hendrik Zimmet
- Henning Ebelt
- Henricus Van Kesteren
- Henrik Wiggers
- Henry Dargie
- Henry Ooi
- Hernan Emilio Francisco Polo Friz
- Hideki Ueno
- Hideo Izawa
- Hideo Kawakami
- Hideyuki Tsuboi
- Hiroaki Kitaoka
- Hiroaki Kiyokawa
- Hiroki Uehara
- Hiroshi Asano
- Hiroshi Domae
- Hiroshi Ito
- Hiroshi Meno
- Hiroshi Sugino
- Hiroshi Takaishi
- Hiroyuki Kawata
- Hisao Hara
- Hisashi Kai
- Holger Killat
- Honarpour N.
- Horacio Alberto Avaca
- Howlett J. G.
- Hugo Luquez
- Huifang Tang
- Ian Buysschaert
- Ibrahim Haldun Muderrisoglu
- Ichiro Michishita
- Ignacio Mackinnon
- Igor Kraiz
- Igor Motylev
- Igor Vakaliuk
- Iman Chouchane
- Imre Szakal
- Inder Anand
- Inder Singh
- Ioannis Barbetseas
- Ioannis Mantas
- Ioannis Styliadis
- Ira Dauber
- Irina Osipova
- Irina Semenova
- Iurii Rudyk
- Ivan Goncharov
- Ivan Majercak
- Ivana Kellnerova
- Ivaylo Vasilev
- Ivo Petrov
- Ivo Podpera
- J Dedrick Jordan
- J Russell Strader
- Jacob Eifer Moller
- Jacob Van Eck
- Jadwiga Nessler
- Jagadeesh Ganji
- James Elliott
- James Fang
- James L Januzzi
- James Rider
- James Watts
- Jan Belohlavek
- Jan Stevlik
- Jana Lukacova
- Janka Skrobakova
- Janos Tomcsanyi
- Janusz Spyra
- Jaroslaw Drozdz
- Jaroslaw Trebacz
- Jason C Legg
- Jason Glover
- Jasper Trevelyan
- Javed Butler
- Javier Segovia Cubero
- Javier Vasallo
- Jean Etienne Ricci
- Jean-Louis Georges
- Jean-Marie Lefebvre
- Jean-Michel Tartiere
- Jean-Noel Trochu
- Jean-Pierre Gueffet
- Jeffrey Martindale
- Jelena Celutkiene
- Jenica N Upshaw
- Jennifer Cook
- Jens Taggeselle
- Jeremy Cox
- Jeroen Schaap
- Jerzy Kopaczewski
- Jianjun Li
- Jindrich Spinar
- Jing Li
- Jing Yan
- Jinguo Zhang
- Jiri Krupicka
- Jiyan Chen
- Joao Carlos Braga
- Joaquin Martinez-Arraras
- Johanna Contreras
- Johannes Remmen
- John Amerena
- John Andrew Morrow
- John Atherton
- John Beltrame
- John Boehmer
- John Cleland
- John Collins
- John Corbelli
- John French
- John Groarke
- John Harris
- John Heitner
- John J V McMurray
- John Kao
- John Mignone
- John Murray
- John Parissis
- John van Hal
- Jolita Badariene
- Jonathan Howlett
- Jooyoung Shin
- Jorge Cheirif
- Jorge Leonardo Cobos Segarra
- Jorge Roberto Aiub
- Jorgen Jeppesen
- Jose Alfredo Pagola Carrasco
- Jose Augusto Ribas Fortes
- Jose Cardona
- Jose Francisco Saraiva
- Jose Luis Accini Mendoza
- Jose Luis Arenas Leon
- Jose Luis Lambert Rodriguez
- Jose Maria Arizon Del Prado
- Jose Ramon Gonzalez Juanatey
- Joseph Massaro
- Joseph Radojevic
- Joseph Rahman
- Joshua Asubiaro
- Jozef Gonsorcik
- Juan Francisco Delgado Jimenez
- Juan Jose Gomez Doblas
- Juan Londono
- Juan Luis Bonilla Palomas
- Julian Alonso Coronel Arroyo
- Julian Javier
- Juliano Cardoso
- Julio Eduardo Nuñez Villota
- Julio Ibañez
- Julio Tallet
- Jun Tanabe
- Junji Kanda
- Justin Ezekowitz
- Justin Taylor
- Kabir Yousuf
- Kahraman Cosansu
- Kalman Toth
- Kamil Zeman
- Kaoru Okishige
- Karel Peterka
- Karel Sochor
- Karen P Alexander
- Karen Sliwa
- Karl Dujardin
- Karl Heilman
- Katalin Bezzegh
- Katerina Naka
- Katsunori Kawamitsu
- Kazuhisa Mitsuo
- Keiji Ujino
- Keijiro Saku
- Keisuke Kida
- Keith Aaronson
- Keith Friedman
- Kenji Ando
- Kenji Onoue
- Kenneth Wong
- Kenshi Fujii
- Kentaro Nakamura
- Keyur Shah
- Kimberly Cruz
- Kimiaki Nagase
- Kirkwood Adams
- Klemens Ablasser
- Kodangudi Ramanathan
- Koichi Node
- Koichiro Sugimura
- Konstantin Zrazhevskiy
- Konstantinos Tsioufis
- Kotaro Numaguchi
- Kouji Kajinami
- Krzysztof Cymerman
- Kumiko Nakayama
- Kunihiko Makino
- Kurt Boman
- Kurt Huber
- Kurtz C. E. GALACTIC-HF Investigators: John R Teerlink
- Ladislav Busak
- Lana Tsao
- Lanfear D. E.
- Larry Allen
- Lars Videbaek
- Larysa Mishchenko
- Larysa Vasilyeva
- Laszlo Mark
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- Voors A. A.
- Vyacheslav Mareev
- Vyacheslav Ryabov
- W Schuyler Jones
- Wael AboAuda
- Wakaya Fujiwara
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- Wayne Gray
- Weiheng Wu
- Weimar Kunz Barroso de Souza
- Weimin Li
- Wentang Niu
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- William Nelson
- William Randall
- Wissam Khalife
- Xin Fu
- Xuelian Zhang
- Xuming Yang
- Yafei Mi
- Yajun Han
- Yang Zheng
- Yanling Qu
- Yann Rosamel
- Yasuchika Takeishi
- Yasuhiro Maejima
- Yasuki Kihara
- Yasunori Ueda
- Yasuo Okumura
- Yasushi Sakata
- Yevgeniya Svishchenko
- Yi Wang
- Yilmaz M. B.
- Yinjun Li
- Yorihiko Higashino
- Yoshihiko Saito
- Yoshiki Hata
- Yoshinori Yasaka
- Yoshitoshi Urabe
- Yu Wei
- Yuemin Sun
- Yugang Dong
- Yuhui Zhang
- Yuji Nakazato
- Yukihiko Momiyama
- Yukihito Sato
- Yukiko Morita
- Yuksel Cavusoglu
- Yuqing Zhang
- Yurii Lymar
- Yuriy Mostovoy
- Yury Lukyanov
- Yury Shvarts
- Yutaka Akatsuka
- Yves Pesant
- Zannad F.
- Zbigniew Bednarkiewicz
- Zbigniew Chmielak
- Zbigniew Gola
- Zbigniew Kalarus
- Zbigniew Pijanowski
- Zbynek Pozdisek
- Zdenek Coufal
- Zdenek Klimsa
- Zdenek Monhart
- Zehra Lale Koldas
- Zerrin Yigit
- Zhanna Kobalava
- Zhanquan Li
- Zhaoping Li
- Zhe Zheng
- Zhenyu Yang
- Zhifang Wang
- Zoltan Laszlo
- Zsolt Zilahi
- Zuyi Yuan
- Zuzana Motovska
- Publication venue
- 'Massachusetts Medical Society'
- Publication date
- 01/01/2021
- Field of study
BACKGROUND The selective cardiac myosin activator omecamtiv mecarbil has been shown to improve cardiac function in patients with heart failure with a reduced ejection fraction. Its effect on cardiovascular outcomes is unknown. METHODS We randomly assigned 8256 patients (inpatients and outpatients) with symptomatic chronic heart failure and an ejection fraction of 35% or less to receive omecamtiv mecarbil (using pharmacokinetic-guided doses of 25 mg, 37.5 mg, or 50 mg twice daily) or placebo, in addition to standard heart-failure therapy. The primary outcome was a composite of a first heart-failure event (hospitalization or urgent visit for heart failure) or death from cardiovascular causes. RESULTS During a median of 21.8 months, a primary-outcome event occurred in 1523 of 4120 patients (37.0%) in the omecamtiv mecarbil group and in 1607 of 4112 patients (39.1%) in the placebo group (hazard ratio, 0.92; 95% confidence interval [CI], 0.86 to 0.99; P = 0.03). A total of 808 patients (19.6%) and 798 patients (19.4%), respectively, died from cardiovascular causes (hazard ratio, 1.01; 95% CI, 0.92 to 1.11). There was no significant difference between groups in the change from baseline on the Kansas City Cardiomyopathy Questionnaire total symptom score. At week 24, the change from baseline for the median N-terminal pro-B-type natriuretic peptide level was 10% lower in the omecamtiv mecarbil group than in the placebo group; the median cardiac troponin I level was 4 ng per liter higher. The frequency of cardiac ischemic and ventricular arrhythmia events was similar in the two groups. CONCLUSIONS Among patients with heart failure and a reduced ejection, those who received omecamtiv mecarbil had a lower incidence of a composite of a heart-failure event or death from cardiovascular causes than those who received placebo. (Funded by Amgen and others; GALACTIC-HF ClinicalTrials.gov number, NCT02929329; EudraCT number, 2016 -002299-28.)