Structural and Thermal Behaviour of a Timber-concrete Prefabricated Composite Wall System

Abstract Wood is the oldest building materials and still now it plays an important role in the construction sector. There are many general advantages in using timber for building purposes. First of all, it is an environmentally friendly, easily recyclable material; it has a low weight in relation to strength, which is advantageous for transport, handling and production; moreover wood has aesthetic qualities, which give great possibilities in architectural design. Lastly wooden structures have an excellent performance in case of earthquake if compared to traditional structures. In Europe the development of the timber-concrete composite structures (TCC) began during a shortage of steel for reinforcement in concrete in the beginning of XX century. TCC application was primarily a refurbishment technique for old historical buildings, during the last 50 years interest in TCC systems has increased, resulting in the construction also of new buildings. This paper presents the analysis of the structural and thermal behaviour of an timber-concrete prefabricated composite wall system, the Concrete Glulam Framed Panel (CGFP) which is a panel made of a concrete slab and a structural glulam frame. The research analyses the structural performance with quasi-static in-plane tests, focused on the in-plane strength and stiffness of individual panels, and the thermal behaviour of the system with steady state tests using an hot box apparatus. The results validate the efficacy of proposed system ensuring the resistance and the dissipative structural behaviour through the hierarchy response characterized by the wood frame, the braced reinforced concrete panel of the singular module and by the rocking effects of global system. On the other side hot-box measures demonstrated a high level of thermal resistance of the system reaching U-values around 0,20 W m -2 K -1 . Moreover experimental data permitted to calibrate a FEM model with which will be possible to study and analyse the panels in different conditions and configuration in both mechanical and thermal field

Nuovi dati faunistici del Bronzo finale e della prima età del Ferro dell’insediamento La Rocca di Chiuso (Lecco) = New faunal data from the Final Bronze Age and the Iron Age settlement of La Rocca di Chiuso (Lecco, Italy)

Nel 1988 il Museo Civico di Lecco effettu\uf2 due sondaggi sul terrazzo del versante settentrionale della Rocca di Chiuso, presso Lecco. Il saggio I, oggetto di questo studio, mise in luce due tratti di muro a secco con andamento SN e la traccia di un terzo allineamento. Il deposito, di limitata profondit\ue0, ha restituito ceramiche dell\u2019et\ue0 del Bronzo finale (XI-X secolo a.C.) e della prima et\ue0 del Ferro (IX-VIII secolo a.C.). Il lotto faunistico conta 191 resti di cui 69 determinati. Si tratta di un complesso poco numeroso ma di notevole interesse perch\ue9 fornisce dati su un areale geografico e su culture ad oggi ancora poco o punto studiate sotto il profilo dell\u2019archeozoologia. Il bue, insieme ai resti attribuibili ai grandi ungulati (44, probabilmente tutti o quasi ad esso riferibili) doveva rappresentare poco pi\uf9 del 42% delle presenze. I resti di capra e pecora e quelli di maiale sono di importanza marginale. Un solo reperto di cane, due resti di cervo. Nonostante la scarsa affidabilit\ue0 statistica il lotto potrebbe riflettere l\u2019economia di una comunit\ue0 essenzialmente agricola, stabile sotto il profilo demografico, e un ambiente aperto, dominato da campi e pascoli.In 1988 the Civic Museum of Lecco carried out some excavations on the northern side terrace of the Rocca di Chiuso near Lecco. In survey 1, object of this paper, two north-south wall sections and the remain of a third wall were found. Pottery of the Final Bronze Age (11th/10th century BC) and of the beginning of the Iron Age (9th/8th century BC) were recovered from it.The faunal assemblage includes 191 remains of which only 69 were identified; it is dated between the Final Bronze Age and the Early Iron Age. The sample is very small, but of considerable significance because it provides data on a geographical and cultural area that is still today barely studied in archaeozoological terms. Cattle, together with those remains attributable to large ungulates (NISP 44, almost all likely to be cattle) represented less than 42% of the identified remains. The remains of goats and sheep and of small ungulatesare up to about 30%. Pigs is of marginal importance. There were only one dog specimen, and two red deer remains. Despite its poor statistical reliability, the assemblage could reflect an economy of a community with a stable demography mainly based on agricultural activities, and consequently an open landscape dominated by fields and pastures

Middle Palaeolithic technical behaviour: Material import-export and Levallois production at the SU 13 of Oscurusciuto rock shelter, Southern Italy

The Oscurusciuto rock shelter, located in southern Italy (Puglia), has yielded a long Middle Palaeolithic stratigraphy rich in lithic assemblages, fireplaces and faunal remains, attesting Neanderthal occupation during the MIS 3. This paper is focused on the stratigraphic unit 13, consisting of a sandy compact deposit mixed with pyroclastic sediment above a thick level of tephra-US 14, identified as Mt. Epomeo green tuff (dated Ar/Ar ~ 55 ka).Level 13 represents the first stable human occupation after the deposition of tephra. Our goal was to examine the lithic assemblage of this stratigraphic unit by means of an interdisciplinary approach (technology, RMU, refitting program) in order to identify the economic behaviour and technical strategies of Neanderthals occupying the stratigraphic unit 13 of Oscurusciuto.The technical strategies applied indicate fragmentation of the reduction processes, as well as probable events of importation and exportation of objects. The lithic material were introduced at different stages of manufacturing. Pieces were introduced in the form of rough objects (pebbles), as well as semi-finished items, and as finished tools. This fragmentation of the chaîne opératoire also demonstrate the palimpsest nature of the level which is made up of different events happening one after another.The main concept of debitage was Levallois, generally realized on local jasper and siliceous limestone pebbles or cortical flakes. Jasper and siliceous limestone flakes, backed flakes and convergent flakes were the technological objectives of the debitage. A marginal volumetric debitage aimed at producing bladelets was also attested

Grotta del Cavallo (Apulia-Southern Italy). The Uluzzian in the mirror

The Uluzzian techno-complex is commonly considered to be a \u201ctransitional industry\u201d mostly on the basis of some inferred characteristics such as a chiefly flake-based production, a small amount of Upper Palaeolithic-like tools and a combination of Middle and Upper Palaeolithic elements both in the toolkit and in the technical systems. Following its discovery, the Uluzzian was identified as the Italian counterpart of the French Ch\ue2telperronian and attributed to Neandertals. However, a study issued in 2011 has established the modern character of the two deciduous teeth found in 1964 in the Uluzzian deposit of Grotta del Cavallo, fostering renewed interests to the Uluzzian culture, which real nature is almost unknown to the international scientific community. Here we provide preliminary results of the study on the lithic assemblage from the earliest Uluzzian layer and on backed pieces from the whole Uluzzian sequence of Grotta del Cavallo (Apulia, Italy), the type site of the Uluzzian. Moreover, besides a thorough review on the stratigraphy of Grotta del Cavallo (Supplementary Materials), we provide updated information on the human remains by presenting two unpublished teeth from the reworked deposit of the same cave. We conclude that the early Uluzzians demonstrate original technological behavior and innovations devoid of any features deriving or directly linked with the late Mousterian of Southern Italy. Therefore, the novelty nature of the Uluzzian techno-complex (with respect to the preceding Mousterian) complies with the recent reassessment of the two deciduous teeth from Grotta del Cavallo in suggesting an earliest migration of modern humans in southern Europe around 45,000 years ago

The RESET project: constructing a European tephra lattice for refined synchronisation of environmental and archaeological events during the last c. 100 ka

This paper introduces the aims and scope of the RESET project (. RESponse of humans to abrupt Environmental Transitions), a programme of research funded by the Natural Environment Research Council (UK) between 2008 and 2013; it also provides the context and rationale for papers included in a special volume of Quaternary Science Reviews that report some of the project's findings. RESET examined the chronological and correlation methods employed to establish causal links between the timing of abrupt environmental transitions (AETs) on the one hand, and of human dispersal and development on the other, with a focus on the Middle and Upper Palaeolithic periods. The period of interest is the Last Glacial cycle and the early Holocene (c. 100-8 ka), during which time a number of pronounced AETs occurred. A long-running topic of debate is the degree to which human history in Europe and the Mediterranean region during the Palaeolithic was shaped by these AETs, but this has proved difficult to assess because of poor dating control. In an attempt to move the science forward, RESET examined the potential that tephra isochrons, and in particular non-visible ash layers (cryptotephras), might offer for synchronising palaeo-records with a greater degree of finesse. New tephrostratigraphical data generated by the project augment previously-established tephra frameworks for the region, and underpin a more evolved tephra 'lattice' that links palaeo-records between Greenland, the European mainland, sub-marine sequences in the Mediterranean and North Africa. The paper also outlines the significance of other contributions to this special volume: collectively, these illustrate how the lattice was constructed, how it links with cognate tephra research in Europe and elsewhere, and how the evidence of tephra isochrons is beginning to challenge long-held views about the impacts of environmental change on humans during the Palaeolithic. © 2015 Elsevier Ltd.RESET was funded through Consortium Grants awarded by the Natural Environment Research Council, UK, to a collaborating team drawn from four institutions: Royal Holloway University of London (grant reference NE/E015905/1), the Natural History Museum, London (NE/E015913/1), Oxford University (NE/E015670/1) and the University of Southampton, including the National Oceanography Centre (NE/01531X/1). The authors also wish to record their deep gratitude to four members of the scientific community who formed a consultative advisory panel during the lifetime of the RESET project: Professor Barbara Wohlfarth (Stockholm University), Professor Jørgen Peder Steffensen (Niels Bohr Institute, Copenhagen), Dr. Martin Street (Romisch-Germanisches Zentralmuseum, Neuwied) and Professor Clive Oppenheimer (Cambridge University). They provided excellent advice at key stages of the work, which we greatly valued. We also thank Jenny Kynaston (Geography Department, Royal Holloway) for construction of several of the figures in this paper, and Debbie Barrett (Elsevier) and Colin Murray Wallace (Editor-in-Chief, QSR) for their considerable assistance in the production of this special volume.Peer Reviewe

Why Are Outcomes Different for Registry Patients Enrolled Prospectively and Retrospectively? Insights from the Global Anticoagulant Registry in the FIELD-Atrial Fibrillation (GARFIELD-AF).

Background: Retrospective and prospective observational studies are designed to reflect real-world evidence on clinical practice, but can yield conflicting results. The GARFIELD-AF Registry includes both methods of enrolment and allows analysis of differences in patient characteristics and outcomes that may result. Methods and Results: Patients with atrial fibrillation (AF) and ≥1 risk factor for stroke at diagnosis of AF were recruited either retrospectively (n = 5069) or prospectively (n = 5501) from 19 countries and then followed prospectively. The retrospectively enrolled cohort comprised patients with established AF (for a least 6, and up to 24 months before enrolment), who were identified retrospectively (and baseline and partial follow-up data were collected from the emedical records) and then followed prospectively between 0-18 months (such that the total time of follow-up was 24 months; data collection Dec-2009 and Oct-2010). In the prospectively enrolled cohort, patients with newly diagnosed AF (≤6 weeks after diagnosis) were recruited between Mar-2010 and Oct-2011 and were followed for 24 months after enrolment. Differences between the cohorts were observed in clinical characteristics, including type of AF, stroke prevention strategies, and event rates. More patients in the retrospectively identified cohort received vitamin K antagonists (62.1% vs. 53.2%) and fewer received non-vitamin K oral anticoagulants (1.8% vs . 4.2%). All-cause mortality rates per 100 person-years during the prospective follow-up (starting the first study visit up to 1 year) were significantly lower in the retrospective than prospectively identified cohort (3.04 [95% CI 2.51 to 3.67] vs . 4.05 [95% CI 3.53 to 4.63]; p = 0.016). Conclusions: Interpretations of data from registries that aim to evaluate the characteristics and outcomes of patients with AF must take account of differences in registry design and the impact of recall bias and survivorship bias that is incurred with retrospective enrolment. Clinical Trial Registration: - URL: http://www.clinicaltrials.gov . Unique identifier for GARFIELD-AF (NCT01090362)

Improved risk stratification of patients with atrial fibrillation: an integrated GARFIELD-AF tool for the prediction of mortality, stroke and bleed in patients with and without anticoagulation.

OBJECTIVES: To provide an accurate, web-based tool for stratifying patients with atrial fibrillation to facilitate decisions on the potential benefits/risks of anticoagulation, based on mortality, stroke and bleeding risks. DESIGN: The new tool was developed, using stepwise regression, for all and then applied to lower risk patients. C-statistics were compared with CHA2DS2-VASc using 30-fold cross-validation to control for overfitting. External validation was undertaken in an independent dataset, Outcome Registry for Better Informed Treatment of Atrial Fibrillation (ORBIT-AF). PARTICIPANTS: Data from 39 898 patients enrolled in the prospective GARFIELD-AF registry provided the basis for deriving and validating an integrated risk tool to predict stroke risk, mortality and bleeding risk. RESULTS: The discriminatory value of the GARFIELD-AF risk model was superior to CHA2DS2-VASc for patients with or without anticoagulation. C-statistics (95% CI) for all-cause mortality, ischaemic stroke/systemic embolism and haemorrhagic stroke/major bleeding (treated patients) were: 0.77 (0.76 to 0.78), 0.69 (0.67 to 0.71) and 0.66 (0.62 to 0.69), respectively, for the GARFIELD-AF risk models, and 0.66 (0.64-0.67), 0.64 (0.61-0.66) and 0.64 (0.61-0.68), respectively, for CHA2DS2-VASc (or HAS-BLED for bleeding). In very low to low risk patients (CHA2DS2-VASc 0 or 1 (men) and 1 or 2 (women)), the CHA2DS2-VASc and HAS-BLED (for bleeding) scores offered weak discriminatory value for mortality, stroke/systemic embolism and major bleeding. C-statistics for the GARFIELD-AF risk tool were 0.69 (0.64 to 0.75), 0.65 (0.56 to 0.73) and 0.60 (0.47 to 0.73) for each end point, respectively, versus 0.50 (0.45 to 0.55), 0.59 (0.50 to 0.67) and 0.55 (0.53 to 0.56) for CHA2DS2-VASc (or HAS-BLED for bleeding). Upon validation in the ORBIT-AF population, C-statistics showed that the GARFIELD-AF risk tool was effective for predicting 1-year all-cause mortality using the full and simplified model for all-cause mortality: C-statistics 0.75 (0.73 to 0.77) and 0.75 (0.73 to 0.77), respectively, and for predicting for any stroke or systemic embolism over 1 year, C-statistics 0.68 (0.62 to 0.74). CONCLUSIONS: Performance of the GARFIELD-AF risk tool was superior to CHA2DS2-VASc in predicting stroke and mortality and superior to HAS-BLED for bleeding, overall and in lower risk patients. The GARFIELD-AF tool has the potential for incorporation in routine electronic systems, and for the first time, permits simultaneous evaluation of ischaemic stroke, mortality and bleeding risks. CLINICAL TRIAL REGISTRATION: URL: http://www.clinicaltrials.gov. Unique identifier for GARFIELD-AF (NCT01090362) and for ORBIT-AF (NCT01165710)

Two-year outcomes of patients with newly diagnosed atrial fibrillation: results from GARFIELD-AF.

AIMS: The relationship between outcomes and time after diagnosis for patients with non-valvular atrial fibrillation (NVAF) is poorly defined, especially beyond the first year. METHODS AND RESULTS: GARFIELD-AF is an ongoing, global observational study of adults with newly diagnosed NVAF. Two-year outcomes of 17 162 patients prospectively enrolled in GARFIELD-AF were analysed in light of baseline characteristics, risk profiles for stroke/systemic embolism (SE), and antithrombotic therapy. The mean (standard deviation) age was 69.8 (11.4) years, 43.8% were women, and the mean CHA2DS2-VASc score was 3.3 (1.6); 60.8% of patients were prescribed anticoagulant therapy with/without antiplatelet (AP) therapy, 27.4% AP monotherapy, and 11.8% no antithrombotic therapy. At 2-year follow-up, all-cause mortality, stroke/SE, and major bleeding had occurred at a rate (95% confidence interval) of 3.83 (3.62; 4.05), 1.25 (1.13; 1.38), and 0.70 (0.62; 0.81) per 100 person-years, respectively. Rates for all three major events were highest during the first 4 months. Congestive heart failure, acute coronary syndromes, sudden/unwitnessed death, malignancy, respiratory failure, and infection/sepsis accounted for 65% of all known causes of death and strokes for <10%. Anticoagulant treatment was associated with a 35% lower risk of death. CONCLUSION: The most frequent of the three major outcome measures was death, whose most common causes are not known to be significantly influenced by anticoagulation. This suggests that a more comprehensive approach to the management of NVAF may be needed to improve outcome. This could include, in addition to anticoagulation, interventions targeting modifiable, cause-specific risk factors for death. CLINICAL TRIAL REGISTRATION: http://www.clinicaltrials.gov. Unique identifier: NCT01090362

Risk profiles and one-year outcomes of patients with newly diagnosed atrial fibrillation in India: Insights from the GARFIELD-AF Registry.

BACKGROUND: The Global Anticoagulant Registry in the FIELD-Atrial Fibrillation (GARFIELD-AF) is an ongoing prospective noninterventional registry, which is providing important information on the baseline characteristics, treatment patterns, and 1-year outcomes in patients with newly diagnosed non-valvular atrial fibrillation (NVAF). This report describes data from Indian patients recruited in this registry. METHODS AND RESULTS: A total of 52,014 patients with newly diagnosed AF were enrolled globally; of these, 1388 patients were recruited from 26 sites within India (2012-2016). In India, the mean age was 65.8 years at diagnosis of NVAF. Hypertension was the most prevalent risk factor for AF, present in 68.5% of patients from India and in 76.3% of patients globally (P < 0.001). Diabetes and coronary artery disease (CAD) were prevalent in 36.2% and 28.1% of patients as compared with global prevalence of 22.2% and 21.6%, respectively (P < 0.001 for both). Antiplatelet therapy was the most common antithrombotic treatment in India. With increasing stroke risk, however, patients were more likely to receive oral anticoagulant therapy [mainly vitamin K antagonist (VKA)], but average international normalized ratio (INR) was lower among Indian patients [median INR value 1.6 (interquartile range {IQR}: 1.3-2.3) versus 2.3 (IQR 1.8-2.8) (P < 0.001)]. Compared with other countries, patients from India had markedly higher rates of all-cause mortality [7.68 per 100 person-years (95% confidence interval 6.32-9.35) vs 4.34 (4.16-4.53), P < 0.0001], while rates of stroke/systemic embolism and major bleeding were lower after 1 year of follow-up. CONCLUSION: Compared to previously published registries from India, the GARFIELD-AF registry describes clinical profiles and outcomes in Indian patients with AF of a different etiology. The registry data show that compared to the rest of the world, Indian AF patients are younger in age and have more diabetes and CAD. Patients with a higher stroke risk are more likely to receive anticoagulation therapy with VKA but are underdosed compared with the global average in the GARFIELD-AF. CLINICAL TRIAL REGISTRATION-URL: http://www.clinicaltrials.gov. Unique identifier: NCT01090362