1,957 research outputs found
Diagnosis and treatment of hereditary angioedema with normal C1 inhibitor
Until recently it was assumed that hereditary angioedema is a disease that results exclusively from a genetic deficiency of the C1 inhibitor. In 2000, families with hereditary angioedema, normal C1 inhibitor activity and protein in plasma were described. Since then numerous patients and families with that condition have been reported. Most of the patients by far were women. In many of the affected women, oral contraceptives, hormone replacement therapy containing estrogens, and pregnancies triggered the clinical symptoms. Recently, in some families mutations in the coagulation factor XII (Hageman factor) gene were detected in the affected persons
Limit on Lorentz and CPT violation of the bound Neutron Using a Free Precession 3He/129Xe co-magnetometer
We report on the search for Lorentz violating sidereal variations of the
frequency difference of co-located spin-species while the Earth and hence the
laboratory reference frame rotates with respect to a relic background field.
The co-magnetometer used is based on the detection of freely precessing nuclear
spins from polarized 3He and 129Xe gas samples using SQUIDs as low-noise
magnetic flux detectors. As result we can determine the limit for the
equatorial component of the background field interacting with the spin of the
bound neutron to be bn < 3.7 x 10^{-32} GeV (95 C.L.).Comment: 5 pages, 4 figure
Hereditary angioedema: New therapeutic options for a potentially deadly disorder
Although the biochemistry of hereditary angioedema (HAE) is fairly well understood today, the lag in diagnosis of a decade or more suggests that clinicians have low awareness of this disease. This lag in diagnosis and hence treatment certainly stems from the rarity and complexity of the presentation which can be easily mistaken for allergic and non-allergic reactions alike. The symptoms of the disease include acute swelling of any or multiple parts of the body. The attacks may be frequent or rare, and they may vary substantially in severity, causing stomach discomfort or periorbital swelling in mild cases and hypovolemic shock due to abdominal fluid shift or asphyxiation in the most severe cases. Given that these patients are at significant risk for poor quality of life and death, greater awareness of this disease is needed to ensure that newly available, effective medications are used in these patients. These new medications represent significant advances in HAE therapy because they are targeted at the plasma cascades implicated in the pathophysiology of this disease. The clinical presentation of HAE, overlapping symptoms with other angioedemas, and available therapies are reviewed
Form factors of chiral primary operators at two loops in ABJ(M)
archiveprefix: arXiv primaryclass: hep-th reportnumber: NORDITA-2013-34 slaccitation: %%CITATION = ARXIV:1305.2422;%%archiveprefix: arXiv primaryclass: hep-th reportnumber: NORDITA-2013-34 slaccitation: %%CITATION = ARXIV:1305.2422;%%archiveprefix: arXiv primaryclass: hep-th reportnumber: NORDITA-2013-34 slaccitation: %%CITATION = ARXIV:1305.2422;%
Passive magnetic shielding in static gradient fields
The effect of passive magnetic shielding on dc magnetic field gradients imposed by both external and internal sources is studied for two idealized shield models: concentric spherical and infinitely-long cylindrical shells of linear material. It is found that higher-order multipoles of an externally applied magnetic field are always shielded progressively better for either geometry by a factor related to the order of the multipole. In regard to the design of internal coil systems, we determine reaction factors for the general multipole field and provide examples of how one can take advantage of the coupling of the coils to the innermost shell to optimize the uniformity of the field. Furthermore, we provide formulae relevant to active magnetic compensation systems which attempt to stabilize the interior fields by sensing and cancelling the exterior fields close to the outermost shell. Overall this work provides a comprehensive framework that is useful for the analysis and optimization of dc magnetic shields, serving as a theoretical and conceptual design guide as well as a starting point and benchmark for finite-element analysis."We gratefully acknowledge the support of the Natural Sciences and Engineering Research
Council of Canada."https://aip.scitation.org/doi/10.1063/1.487371
Long term study of the seismic environment at LIGO
The LIGO experiment aims to detect and study gravitational waves using ground
based laser interferometry. A critical factor to the performance of the
interferometers, and a major consideration in the design of possible future
upgrades, is isolation of the interferometer optics from seismic noise. We
present the results of a detailed program of measurements of the seismic
environment surrounding the LIGO interferometers. We describe the experimental
configuration used to collect the data, which was acquired over a 613 day
period. The measurements focused on the frequency range 0.1-10 Hz, in which the
secondary microseismic peak and noise due to human activity in the vicinity of
the detectors was found to be particularly critical to interferometer
performance. We compare the statistical distribution of the data sets from the
two interferometer sites, construct amplitude spectral densities of seismic
noise amplitude fluctuations with periods of up to 3 months, and analyze the
data for any long term trends in the amplitude of seismic noise in this
critical frequency range.Comment: To be published in Classical and Quantum Gravity. 24 pages, 15
figure
Not a melting pot: Plant species aggregate in their non-native range
Aim Plant species continue to be moved outside of their native range by human activities. Here, we aim to determine whether, once introduced, plants assimilate into native communities or whether they aggregate, thus forming mosaics of native- and alien-rich communities. Alien species might aggregate in their non-native range owing to shared habitat preferences, such as their tendency to establish in high-biomass, species-poor areas. Location Twenty-two herbaceous grasslands in 14 countries, mainly in the temperate zone. Time period 2012-2016. Major taxa studied Plants. Methods We used a globally coordinated survey. Within this survey, we found 46 plant species, predominantly from Eurasia, for which we had co-occurrence data in their native and non-native ranges. We tested for differences in co-occurrence patterns of 46 species between their native (home) and non-native (away) range. We also tested whether species had similar habitat preferences, by testing for differences in total biomass and species richness of the patches that species occupy in their native and non-native ranges. Results We found the same species to show different patterns of association depending on whether they were in their native or non-native range. Alien species were negatively associated with native species; instead, they aggregated with other alien species in species-poor, high-biomass communities in their non-native range compared with their native range. Main conclusions The strong differences between the native (home) and non-native (away) range in species co-occurrence patterns are evidence that the way in which species associate with resident communities in their non-native range is not species dependent, but is instead a property of being away from their native range. These results thus highlight that species might undergo important ecological changes when introduced away from their native range. Overall, we show origin-dependent associations that result in novel communities, in which alien-rich patches exist within a mosaic of native-dominated communities
Two-loop Sudakov form factor in ABJM
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New treatments addressing the pathophysiology of hereditary angioedema
Hereditary angioedema is a serious medical condition caused by a deficiency of C1-inhibitor. The condition is the result of a defect in the gene controlling the synthesis of C1-inhibitor, which regulates the activity of a number of plasma cascade systems. Although the prevalence of hereditary angioedema is low – between 1:10,000 to 1:50,000 – the condition can result in considerable pain, debilitation, reduced quality of life, and even death in those afflicted. Hereditary angioedema presents clinically as cutaneous swelling of the extremities, face, genitals, and trunk, or painful swelling of the gastrointestinal mucosa. Angioedema of the upper airways is extremely serious and has resulted in death by asphyxiation
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