Atrial septal defect in adults is associated with airway hyperresponsiveness

Objective: The association between secundum atrial septal defects (ASD) and asthma-like dyspnea with consequent long-term pulmonary inhalant use, is poorly understood in adult ASD patients. Airway hyperresponsiveness is suggested to be the underlying mechanism of cardiac asthma from mitral valve disease and ischemic cardiomyopathy. We hypothesized that airway hyperresponsiveness may also be found in adult ASD patients. Our aim was to study airway responsiveness in adult ASD patients before percutaneous closure and at short-and long-term postprocedural follow-up. Methods: This prospective study included 31 ASD patients (65% female, mean age 49 ± 15y) who underwent spirometry and bronchoprovocation testing pre-and six-month postprocedurally, with additional bronchoprovocation at 2-year follow-up. Airway hyperresponsiveness was defined as ≥20% fall of forced expiratory volume in 1-second (FEV1) following <8.0 mg/mL of inhaled methacholine. Results: Airway hyperresponsiveness was found in 19/30 patients (63%[95%CI 45%-81%]; post hoc statistical power = 89%). Asthma-like symptoms wheezing, chest tightness, and cough were more frequently reported in airway hyperresponsive patients. Airway responsiveness was not influenced by successful percutaneous ASD closure, corresponding to persistence of asthma-like symptoms postclosure. Regardless of airway responsiveness, postprocedural right-sided reverse remodeling significantly improved dyspnea and pulmonary function. Conclusions: This study is the first to report a high prevalence of airway hyperresponsiveness in a cohort of unrepaired adult ASD patients, and confirms the association between asthma-like symptoms and ASD in adults. Attention to symptoms and pulmonary function should be given during clinical follow-up of adult ASD patients, both before and long after repair

Tema 14: Aglomerados de estrelas

We present observations of the symbiotic star CH Cyg with a new JHK-band beam combiner mounted to the IOTA interferometer. The new beam combiner consists of an anamorphic cylindrical lens system and a grism, and allows the simultaneous recording of spectrally dispersed J-, H- and K-band Michelson interferograms. The observations of CH Cyg were conducted on 5, 6, 8 and 11 June 2001 using baselines of 17m to 25m. From the interferograms of CH Cyg, J-, H-, and K-band visibility functions can be determined. Uniform-disk fits to the visibilities give, e.g., stellar diameters of (7.8 ± 0.6) mas and (8.7 ± 0.8) mas in H and K, respectively. Angular stellar filter radii and Rosseland radii are derived from the measured visibilities by fitting theoretical center-to-limb intensity variations (CLVs) of Mira star models. The available HIPPARCOS parallax of CH Cyg allows us to determine linear radii. For example, on the basis of the K-band visibility, Rosseland radii in the range of 214 to 243 solar radii can be derived utilizing CLVs of different fundamental mode Mira models as fit functions. These radii agree well within the error bars with the corresponding theoretical model Rosseland radii of 230 to 282 solar radii. Models of first overtone pulsators are not in good agreement with the observations. The wavelength dependence of the stellar diameter can be well studied by using visibility ratios V(λ1)/V(λ2) since ratios of visibilities of different spectral channels can be measured with higher precision than absolute visibilities. We found that the 2.03 μm uniform disk diameter of CH Cyg is approximately 1.1 times larger than the 2.15 μm and 2.26 μm uniform-disk diameter

Research of thermal processes in hollow cathode

A hollow cathode in a heavy-current arc discharge of a lower pressure has been considered in the paper. The purpose of the paper is to investigate the interaction of a hollow cathode with plasma of an arc discharge on the basis of an experimental and theoretical study of thermal condition of the hollow cathode. In the result of the research the thermal flow dependence on the arc current has been obtained and substantiated theoretically, an analysis of models of the electrical transfer and plasma parameters in a cathode zone has been given. The research procedure permits to study cathode processes and to design a limiting mode of cathode assembly of the heavy-current vacuum plasma generator. The results of the research have been used in the educational process in the course &quot;Theory of Electrical Heating&quot;, section &quot;Arc Discharges of Lower Pressure&quot;Available from VNTIC / VNTIC - Scientific & Technical Information Centre of RussiaSIGLERURussian Federatio

Bioethics in Russia: History and Present-day Problems

10.1353/asb.2015.0041Asian Bioethics Review75481-49

From the Editor

10.1353/asb.2015.0040Asian Bioethics Review75423-42