The Transition between Telomerase and ALT Mechanisms in Hodgkin Lymphoma and Its Predictive Value in Clinical Outcomes

International audienceBackground: We analyzed telomere maintenance mechanisms (TMMs) in lymph node samples from HL patients treated with standard therapy. The TMMs correlated with clinical outcomes of patients. Materials and Methods: Lymph node biopsies obtained from 38 HL patients and 24 patients with lymphadenitis were included in this study. Seven HL cell lines were used as in vitro models. Telomerase activity (TA) was assessed by TRAP assay and verified through hTERT immunofluorescence expression; alternative telomere lengthening (ALT) was also assessed, along with EBV status. Results: Both TA and ALT mechanisms were present in HL lymph nodes. Our findings were reproduced in HL cell lines. The highest levels of TA were expressed in CD30−/CD15− cells. Small cells were identified with ALT and TA. Hodgkin and Reed Sternberg cells contained high levels of PML bodies, but had very low hTERT expression. There was a significant correlation between overall survival (p < 10−3), event-free survival (p < 10−4), and freedom from progression (p < 10−3) and the presence of an ALT profile in lymph nodes of EBV+ patients. Conclusion: The presence of both types of TMMs in HL lymph nodes and in HL cell lines has not previously been reported. TMMs correlate with the treatment outcome of EBV+ HL patients

Analyse morphologique et composition architecturale

Cette recherche vise à définir les éléments et les rapports de la composition architecturale. A travers l'infinité des compositions, elle cherche à reconnaître un nombre limité d'éléments architecturaux, ou plutôt de niveaux de structuration, ainsi qu'un nombre limité de "figures" de composition

The Amnesty Exception to the Jurisdiction of the International Criminal Court

This article examines the paradoxical question of whether the International Criminal Court will require justice at the expense of peace. Notwithstanding the popular catch phrase of the 1990s - no peace without justice \u27 - peace and justice are sometimes incompatible goals. To end an international or internal conflict, negotiations must often be conducted with the very leaders who were responsible for war crimes and crimes against humanity. When this is the case, insisting on criminal prosecutions can prolong the conflict, resulting in more death, destruction, and human suffering

Tokat : essai sur l’architecture domestique et la forme urbaine

Borie Alain, Pinon Pierre, Yerasimos Stéphane. Tokat : essai sur l’architecture domestique et la forme urbaine. In: Anatolia moderna - Yeni anadolu, Tome 1, 1991. pp. 239-273

L'occidentalisation d'Istanbul au XIXe siècle

Ensemble d'analyses sur l'occidentalisation d'Istanbul : la règlementation urbaine et municipale (1839-1869) et la nouvelle organisation de l'espace urbain : étude morphologique et étude des processus fonciers à propos des lotissements de Constantinople ; les mosquées tardo-ottomanes (1748-1913) et l'évolution de leurs caractéristiques architecturales

L'occidentalisation d'Istanbul au XIXe siècle

d'eau, le nettoyage des rues ou les normes pour les constructions neuves. La deuxième partie explore les influences de l'architecture occidentale. Enfin la dernière partie analyse les types architecturaux ottomans et présente de nombreuses réalisations architecturale

Formes urbaines et sites de méandres

A travers le cas des villes implantées dans des sites de méandres, est expérimentée une méthode d'analyse urbaine, morphologique et historique qui permet d'élaborer des typologies des sites, des formes urbaines et des attitudes urbaines vis-à-vis des site

Maisons à patio

Les maisons à patio sont étudiées sous l'angle de la morphologie urbaine et architecturale, sous l'angle climatique, historique et du mode de vie

Radiopacity of alloplastic bone grafts measured with cone beam computed tomography: An analysis in rabbit calvaria

Availability of adequate bone structure for dental implants is still a problem in dentistry. Alloplastic grafts, which promote bone regeneration, are used as bone substitutes in orthopedic and oral surgical procedures. The aim of this study was to evaluate the radiopacity of three different synthetic bone grafts in rabbit calvaria, over 3 months, using cone beam computed tomography (CBCT). Four critical-size defects were made on the calvaria of 11 rabbits. The lesions were classified into three groups according to the alloplastic grafts they received: Osteon® 70/30, Osteon collagen®, and Osteon II® groups. The fourth group received blood clot, and served as a control. The bone samples were collected and analyzed with CBCT after the 1st, 2nd, and 3rd month. One month after surgery, the lesions that received Osteon® 70/30 and Osteon collagen® grafts showed the highest radiopacity compared to the lesions with Osteon II® and blood clot. After the 2nd month, the radiopacity values between the three groups that received the grafts were more similar compared to the group with blood clot. After the 3rd month, the lesions with Osteon® 70/30 graft showed the highest radiopacity values, followed by Osteon collagen® and Osteon II® groups. The group that received blood clot showed the lowest radiopacity values. In conclusion, the grafts used in this study had higher radiopacity values compared to blood clot. Among the grafts used, the Osteon® 70/30 graft showed the highest radiopacity values in the 3-month period

L'occidentalisation d'Istanbul et des grandes villes de l'Empire ottoman aux XIXe et XXe siècles : Izmir, Beyrouth, Damas

Elargissement d'une précédente recherche sur l'occidentalisation de l'espace urbain ottoman où étaient abordées les modalités principales à partir du modèle stanbouliote. Cet élargissement procède d'un questionnement fondamental, touchant l'antériorité de ce modèle, considéré jusqu'ici presque comme un postulat, le mode d'exportation d'un modèle, ou plutôt la nécessité de savoir si la capitale est le passage obligé de la diffusion du processus d'occidentalisation vers les provinces, et enfin la pertinence du modèle ottoman dans l'évolution des provinces, notamment après leur détachement du corps de l'Empir