A brief review of "little string theories"

This is a brief review of the current state of knowledge on "little string theories", which are non-gravitational theories having several string-like properties. We focus on the six dimensional maximally supersymmetric "little string theories" and describe their definition, some of their simple properties, the motivations for studying them, the DLCQ and holographic constructions of these theories and their behaviour at finite energy density. (Contribution to the proceedings of Strings '99 in Potsdam, Germany.)Comment: 11 pages, contribution to Strings '99 proceeding

The effects of treatment as usual versus a computerized clinical decision aid on shared decision-making in the treatment of psychotic disorders

Background and objectives: People with psychotic disorders can experience a lack of active involvement in their decisional process. Clinical decision aids are shared decision-making tools which are currently rarely used in mental healthcare. We examined the effects of Treatment E-Assist (TREAT), a computerized clinical decision aid in psychosis care, on shared decision-making and satisfaction with consultations as assessed by patients. Methods: A total of 187 patients with a psychotic disorder participated. They received either treatment as usual in the first phase (TAU1), TREAT in the second phase or treatment as usual in the third phase of the trial (TAU2). The Decisional Conflict Scale was used as primary outcome measure for shared decision-making and patient satisfaction as secondary outcome. Results: A linear mixed model analysis found no significant effects between TAU 1 (β = −0.54, SE = 2.01, p = 0.80) and TAU 2 (β = −1.66, SE = 2.63, p = 0.53) compared to TREAT on shared decision-making. High patient rated satisfaction with the consultations was found with no significant differences between TAU 1 (β = 1.48, SE = 1.14, p = 0.20) and TAU 2 (β = 2.26, SE = 1.33, p = 0.09) compared to TREAT. Conclusion: We expected TREAT to enhance shared decision-making without decreasing satisfaction with consultations. However, no significant differences on shared decision-making or satisfaction with consultations were found. Our findings suggest that TREAT is safe to implement in psychosis care, but more research is needed to fully understand its effects on the decisional process.</p

Curved BPS domain walls and RG flow in five dimensions

We determine, in the context of five-dimensional ${\cal N}=2$ gauged supergravity with vector and hypermultiplets, the conditions under which curved (non Ricci flat) supersymmetric domain wall solutions may exist. These curved BPS domain wall solutions may, in general, be supported by non-constant vector and hyper scalar fields. We establish our results by a careful analysis of the BPS equations as well as of the associated integrability conditions and the equations of motion. We construct an example of a curved BPS solution in a gauged supergravity model with one hypermultiplet. We also discuss the dual description of curved BPS domain walls in terms of RG flows.Comment: 18 pages, LaTeX, 5 figures; added reference

The Neurological Ecology of Fear: Insights Neuroscientists and Ecologists Have to Offer one Another

That the fear and stress of life-threatening experiences can leave an indelible trace on the brain is most clearly exemplified by post-traumatic stress disorder (PTSD). Many researchers studying the animal model of PTSD have adopted utilizing exposure to a predator as a life-threatening psychological stressor, to emulate the experience in humans, and the resulting body of literature has demonstrated numerous long-lasting neurological effects paralleling those in PTSD patients. Even though much more extreme, predator-induced fear and stress in animals in the wild was, until the 1990s, not thought to have any lasting effects, whereas recent experiments have demonstrated that the effects on free-living animals are sufficiently long-lasting to even affect reproduction, though the lasting neurological effects remain unexplored. We suggest neuroscientists and ecologists both have much to gain from collaborating in studying the neurological effects of predator-induced fear and stress in animals in the wild. We outline the approaches taken in the lab that appear most readily translatable to the field, and detail the advantages that studying animals in the wild can offer researchers investigating the “predator model of PTSD.

Holographic Kondo Model in Various Dimensions

We study the addition of localised impurities to U(N) Supersymmetric Yang-Mills theories in (p+1)-dimensions by using the gauge/gravity correspondence. From the gravity side, the impurities are introduced by considering probe D(8-p)-branes extendingalong the time and radial directions and wrapping an (7-p)-dimensional submanifold of the internal (8-p)-sphere, so that the degrees of freedom are point-like from the gauge theory perspective. We analyse both the configuration in which the branes generate straight flux tubes -corresponding to actual single impurities - and the one in which connected flux tubes are created- corresponding to dimers. We discuss the thermodynamics of both the configurations and the related phase transition. In particular, the specific heat of the straight flux-tube configuration is negative for p<3, while it is never the case for the connected one. We study the stability of the system by looking at the impurity fluctuations. Finally, we characterise the theory by computing one- and two-point correlators of the gauge theory operators dual to the impurity fluctuations. Because of the underlying generalised conformal structure, such correlators can be expressed in terms of an effective coupling constant (which runs because of its dimensionality) and a generalised conformal dimension.Comment: 56 pages, 3 figures; v2: typos correcte

The development and evaluation of a computerized decision aid for the treatment of psychotic disorders

Abstract Background Routinely monitoring of symptoms and medical needs can improve the diagnostics and treatment of medical problems, including psychiatric. However, several studies show that few clinicians use Routine Outcome Monitoring (ROM) in their daily work. We describe the development and first evaluation of a ROM based computerized clinical decision aid, Treatment-E-Assist (TREAT) for the treatment of psychotic disorders. The goal is to generate personalized treatment recommendations, based on international guidelines combined with outcomes of mental and physical health acquired through ROM. We present a pilot study aimed to assess the feasibility of this computerized clinical decision aid in daily clinical practice by evaluating clinicians’ experiences with the system. Methods Clinical decision algorithms were developed based on international schizophrenia treatment guidelines and the input of multidisciplinary expert panels from multiple psychiatric institutes. Yearly obtained diagnostic (ROM) information of patients was presented to treating clinicians combined with treatment suggestions generated by the algorithms of TREAT. In this pilot study 6 clinicians and 16 patients of Lentis Psychiatric Institute used the application. Clinicians were interviewed and asked to fill out self-report questionnaires evaluating their opinions about ROM and the effectiveness of TREAT. Results Six clinicians and 16 patients with psychotic disorders participated in the pilot study. The clinicians were psychiatrists, physicians and nurse-practitioners which all worked at least 8 years in mental health care of which at least 3 years treating patients with psychotic illnesses. All Clinicians found TREAT easy to use and would like to continue using the application. They reported that TREAT offered support in using diagnostic ROM information when drafting the treatment plans, by creating more awareness of current treatment options. Conclusion This article presents a pilot study on the implementation of a computerized clinical decision aid linking routine outcome monitoring to clinical guidelines in order to generate personalized treatment advice. TREAT was found to be feasible for daily clinical practice and effective based on this first evaluation by clinicians. However, adjustments have to be made to the system and algorithms of the application. The ultimate goal is to provide appropriate evidence based care for patients with severe mental illnesses

Effective Actions for Massive Kaluza-Klein States on AdS_3 x S^3 x S^3

We construct the effective supergravity actions for the lowest massive Kaluza-Klein states on the supersymmetric background AdS_3 x S^3 x S^3. In particular, we describe the coupling of the supergravity multiplet to the lowest massive spin-3/2 multiplet which contains 256 physical degrees of freedom and includes the moduli of the theory. The effective theory is realized as the broken phase of a particular gauging of the maximal three-dimensional supergravity with gauge group SO(4) x SO(4). Its ground state breaks half of the supersymmetries leading to 8 massive gravitinos acquiring mass in a super Higgs effect. The holographic boundary theory realizes the large N=(4,4) superconformal symmetry.Comment: 31 pages, v2: minor change

Background geometry of DLCQ M theory on a p-torus and holography

Via supergravity, we argue that the infinite Lorentz boost along the M theory circle a la Seiberg toward the DLCQ M theory compactified on a p-torus (p<5) implies the holographic description of the microscopic theory. This argument lets us identify the background geometries of DLCQ $M$ theory on a p-torus; for p=0 (p=1), the background geometry turns out to be eleven-dimensional (ten-dimensional) flat Minkowski space-time, respectively. Holography for these cases results from the localization of the light-cone momentum. For p = 2,3,4, the background geometries are the tensor products of an Anti de Sitter space and a sphere, which, according to the AdS/CFT correspondence, have the holographic conformal field theory description. These holographic descriptions are compatible to the microscopic theory of Seiberg based on $\tilde{M}$ theory on a spatial circle with the rescaled Planck length, giving an understanding of the validity of the AdS/CFT correspondence.Comment: 16 pages, Revtex, no figure

Holography and Defect Conformal Field Theories

We develop both the gravity and field theory sides of the Karch-Randall conjecture that the near-horizon description of a certain D5-D3 brane configuration in string theory, realized as AdS_5 x S^5 bisected by an AdS_4 x S^2 "brane", is dual to N=4 Super Yang-Mills theory in R^4 coupled to an R^3 defect. We propose a complete Lagrangian for the field theory dual, a novel "defect superconformal field theory" wherein a subset of the fields of N=4 SYM interacts with a d=3 SU(N) fundamental hypermultiplet on the defect preserving conformal invariance and 8 supercharges. The Kaluza-Klein reduction of wrapped D5 modes on AdS_4 x S^2 leads to towers of short representations of OSp(4|4), and we construct the map to a set of dual gauge-invariant defect operators O_3 possessing integer conformal dimensions. Gravity calculations of and are given. Spacetime and N-dependence matches expectations from dCFT, while the behavior as functions of lambda = g^2 N at strong and weak coupling is generically different. We comment on a class of correlators for which a non-renormalization theorem may still exist. Partial evidence for the conformality of the quantum theory is given, including a complete argument for the special case of a U(1) gauge group. Some weak coupling arguments which illuminate the duality are presented.Comment: 47 pages, LaTeX, 2 figures, feynmf. v2: fixed minor errors, added references. v3: fixed more typo

Validation of a food frequency questionnaire to assess folate intake of Dutch elderly people

Folate is required for 1-carbon metabolism and deficiency in folate leads to megaloblastic anemia. Low levels of folate have been associated with increased risk of vascular disease. To investigate whether RDA of folate are met, habitual folate intake needs to be assessed reliably. We developed a FFQ to specifically measure folate intake over the previous 3 months in elderly people in the Netherlands. Major sources of folate intake, i.e. foods contributing to at least 80 % of the average folate intake, were identified through an analysis of the second Dutch Food Consumption Survey for the sub-population of men and women aged 50¿70. In 2000 and 2001, folate intake was estimated with this questionnaire in 1286 individuals aged 50-75 years. Concentrations of serum and erythrocyte folate served as biomarkers with which relative validity of the questionnaire was assessed. The same FFQ was repeated after 3 years in 803 subjects in order to assess long-term reproducibility. Mean folate intake was estimated to be 196 (sd 69) ¿g/d. Spearman correlation coefficients between folate intake and serum and erythrocyte concentrations were 0·14 (P <0·01) and 0·05 (P = 0·06) respectively. Spearman correlations between folate intakes measured at baseline and after 3 years were 0·58 (P <0·01). 47 % of the participants were classified in the same quartiles on the two occasions. Our FFQ showed a weak correlation between folate intake and blood folate concentrations and reproducibility was acceptable. This FFQ is able to rank subjects according to their folate intake