Spectral Efficiency Optimization in Flexi-Grid Long-Haul Optical Systems

Flexible grid optical networks allow a better exploitation of fiber capacity, by enabling a denser frequency allocation. A tighter channel spacing, however, requires narrower filters, which increase linear intersymbol interference (ISI), and may dramatically reduce system reach. Commercial coherent receivers are based on symbol by symbol detectors, which are quite sensitive to ISI. In this context, Nyquist spacing is considered as the ultimate limit to wavelength-division multiplexing (WDM) packing. In this paper, we show that by introducing a limited-complexity trellis processing at the receiver, either the reach of Nyquist WDM flexi-grid networks can be significantly extended, or a denser-than-Nyquist channel packing (i.e., a higher spectral efficiency (SE)) is possible at equal reach. By adopting well-known information-theoretic techniques, we design a limited-complexity trellis processing and quantify its SE gain in flexi-grid architectures where wavelength selective switches over a frequency grid of 12.5GHz are employed.Comment: 7 pages, 9 figure

Custom Dual Transportation Mode Detection by Smartphone Devices Exploiting Sensor Diversity

Making applications aware of the mobility experienced by the user can open the door to a wide range of novel services in different use-cases, from smart parking to vehicular traffic monitoring. In the literature, there are many different studies demonstrating the theoretical possibility of performing Transportation Mode Detection (TMD) by mining smart-phones embedded sensors data. However, very few of them provide details on the benchmarking process and on how to implement the detection process in practice. In this study, we provide guidelines and fundamental results that can be useful for both researcher and practitioners aiming at implementing a working TMD system. These guidelines consist of three main contributions. First, we detail the construction of a training dataset, gathered by heterogeneous users and including five different transportation modes; the dataset is made available to the research community as reference benchmark. Second, we provide an in-depth analysis of the sensor-relevance for the case of Dual TDM, which is required by most of mobility-aware applications. Third, we investigate the possibility to perform TMD of unknown users/instances not present in the training set and we compare with state-of-the-art Android APIs for activity recognition.Comment: Pre-print of the accepted version for the 14th Workshop on Context and Activity Modeling and Recognition (IEEE COMOREA 2018), Athens, Greece, March 19-23, 201

Development of a Gallium-Containing One-Bead One-Compound Peptide Library for the Discovery of New Molecular Imaging Probes

An eight amino acid one-bead one-compound (OBOC) peptide library, containing a gallium-DOTA complex, was developed in an attempt to overcome common issues associated with the later addition of radionuclides to peptide chains of imaging probes. The further addition of a radionuclide often changes the binding properties of a peptide, as it adds bulk, and possibly charges. MALDI (matrix-assisted laser desorption ionization) tandem mass spectrometry was determined to be the method of choice in order to deconvolute gallium-containing peptide sequences. The library obtained was screened against the breast cancer cell lines MDA-MB-231 and MCF-7. Positive beads were isolated and sequences were determined before ligand validation, which included synthesis of peptides and further testing for binding affinity and specificity. Furthermore, positive peptides obtained through screening were developed into potential imaging agents by radiolabelling with 68Ga

Hemolytic vascular inflammation: an update

Made available in DSpace on 2016-11-10T13:31:43Z (GMT). No. of bitstreams: 1 pmed_26969775.pdf: 607909 bytes, checksum: c33e900140de01738d42c6807067a943 (MD5) Previous issue date: 201638555

Prognostic significance of primary-tumor extension, stage and grade of nuclear differentiation in patients with renal cell carcinoma

Surgery remains the preferred therapy for renal cell carcinoma. The various adjunctive or complementary therapies currently yield disappointing results. Identifying reliable prognostic factors could help in selecting patients most likely to benefit from postoperative adjuvant therapies. We reviewed the surgical records of 78 patients who had undergone radical nephrectomy with lymphadenectomy for renal cell carcinoma, matched for type of operation and histology. According to staging (TNM), 5.1% of the patients were classified as stage I, 51.3% as stage II, 29.5% as stage III and 14.5% as stage IV. Of the 78 patients 40 were T2N0 and 21 T3aN0. Tumor grading showed that 39.7% of the patients had well-differentiated tumors(G1), 41.1% moderately-differentiated (G2), and 19.2% poorly-differentiated tumors (G3). Overall actuarial survival at 5 and 10 years was 100% for stage 1; 91.3% at 5 years and 83.1% at 10 years for stage II; 45.5% and 34.1% for stage III; and 29.1% and nil for stage IV (stage II vs stage III p = 0.0001). Patients with tumors confined to the kidney (pT2N0) had better 5- and 10-year survival rates than patients with tumors infiltrating the perirenal fat (pT3aN0) (p = 0.000006). Survival differed according to nuclear grading (G1 vs G3 ; p = 0.000005; G2 vs G3; p = 0.0009). In conclusion our review identified tumor stage, primary-tumor extension, and the grade of nuclear differentiation as reliable prognostic factors in patients with renal cell carcinomas

Public Policies Development: Convergences And Divergences In The Bodoquena-pantanal Geopark

The Bodoquena-Pantanal Geopark was created by State edict in 2009, but its implementation and effective operation still depend on investments and actions. The public resources for investments are limited, and the private sector will invest if the State assures that the enterprise will be stable and profitable. This survey aims to analyze the convergences and divergences among public policies that occurs in the Geopark site. The method employed was the analysis by an adaptation of the MACTOR Method verifying implicit and explicit policies goals. The results indicate that most policies have common goals and are converging, although they are not always clear. In conclusion, the Geopark is a new demand for the government, that is linked to recurring and suppressed demands regarding regional development, and this policies converge among each other, if executed properly, can contribute to the Geopark implementation, which will act as a driving force to the regional development.19315517