Self-assembled platinum(II) complexes for anion recognition.

The focus of this thesis is the development of novel anion receptors possessing conformational flexibility through the use of a simple inorganic framework. The complex cation, [PtL4]2+, can adopt four conformations inspired by calix[4]arene-based receptors: \u27cone\u27, \u27partial cone\u27, \u271,2-alternate\u27 or \u271,3-alternate\u27. The first part of the thesis involves the synthesis, characterization and examination of the binding properties of three generations of anion receptors using 1H NMR spectroscopy and X-ray crystallography. The first generation receptor is [PtL4]2+ where L = 3-nbutylnicotinamide. Solution studies show moderate binding constants in polar solvents with preference for 1:2 binding of planar bidentate anions such as CH3CO2- and NO3-. Conformational flexibility is removed in the second generation receptor. The receptor is preorganized for 1:2 binding of planar bidendate anions with two bis-3,5-nbutylnicotinamide ligands coordinated to [Pt(2,2\u27-bipy)]2+. The results show diminished receptor:anion interactions in both solution and solid state. The third generation receptor consists of [PtL4]2+ where L = 8nbutylureaisoquinoline. The association constants are high in very polar solvent with the 1,2-alternate conformation preferred for the binding of spherical halide anions. The cone conformation is seen when binding tetrahedral shaped oxo-anions. This trend is also confirmed by X-ray crystal structure data. The second part of the thesis investigates the conformational stability and interconversion barriers of several rotameric model complexes using 1H NMR spectroscopy and molecular mechanics. The number of possible conformations in most of the compounds is simplified to two, syn and anti. The anti conformation is the most stable and interconversion barriers range from 69 - 76 kJ/mol. Finally, the last section of the thesis explores the use of mass spectrometry and fluorescence spectroscopy as tools for qualitative analysis of the binding interactions between our third generation receptor and several different anions. Trends in anion selectivity are monitored. Source: Dissertation Abstracts International, Volume: 66-11, Section: B, page: 5971. Thesis (Ph.D.)--University of Windsor (Canada), 2005

Impact of Gene-Gender Effects of Adrenergic Polymorphisms on Hypothalamic-Pituitary-Adrenal Axis Activity in Depressed Patients

Objective: There is overwhelming evidence that activation of the hypothalamic-pituitary-adrenal (HPA) system plays a major role in depression and cardiovascular disease in genetically susceptible individuals. We hypothesized that due to the multiple interactions between the sympathetic and the HPA systems via adrenoceptors, polymorphisms in these genes could have an impact on HPA axis activity in major depression. Methods: Using the dexamethasone/corticotrophin-releasing hormone (DEX/CRH) test, we investigated the association of alpha 2-adrenoceptor (ADRA2A -1291C -> G) and the beta 2-adrenoceptor gene (ADRB2 Arg16Gly) in 189 patients with major depression during the acute state of the disease and after remission. Results: Male ADRA2A -1291G allele homozygotes showed significant pretreatment HPA axis hyperactivity, with increased adrenocorticotropin (ACTH; F = 4.9, d.f. = 2, p = 0.009) and cortisol responses (F = 6.4, d.f. = 2, p = 0.003). In contrast, female ADRB2 Arg/Arg homozygotes had increased pretreatment ACTH (F = 7.17, d.f. = 2, p = 0.001) and cortisol (F = 8.95, d.f. = 2, p = 0.000) levels. Interestingly, in the respective genotypes, the stress hormones remained elevated in the second DEX/CRH test, despite a reduction in depressive symptoms. Conclusions: This study provides evidence that, depending on gender and polymorphisms, there is continuous HPA axis overdrive in a proportion of patients irrespective of the status of depression. Considering the importance of stress hormones for cardiovascular disorders, our data might suggest that these patients are at high risk of comorbidity between depression and cardiovascular disorders. Copyright (c) 2008 S. Karger AG, Base

Logarithmic corrections in the free energy of monomer-dimer model on plane lattices with free boundaries

Using exact computations we study the classical hard-core monomer-dimer models on m x n plane lattice strips with free boundaries. For an arbitrary number v of monomers (or vacancies), we found a logarithmic correction term in the finite-size correction of the free energy. The coefficient of the logarithmic correction term depends on the number of monomers present (v) and the parity of the width n of the lattice strip: the coefficient equals to v when n is odd, and v/2 when n is even. The results are generalizations of the previous results for a single monomer in an otherwise fully packed lattice of dimers.Comment: 4 pages, 2 figure

Inclusive One Jet Production With Multiple Interactions in the Regge Limit of pQCD

DIS on a two nucleon system in the regge limit is considered. In this framework a review is given of a pQCD approach for the computation of the corrections to the inclusive one jet production cross section at finite number of colors and discuss the general results.Comment: 4 pages, latex, aicproc format, Contribution to the proceedings of "Diffraction 2008", 9-14 Sep. 2008, La Londe-les-Maures, Franc

Parameterized Study of the Test Cover Problem

We carry out a systematic study of a natural covering problem, used for identification across several areas, in the realm of parameterized complexity. In the {\sc Test Cover} problem we are given a set $[n]=\{1,...,n\}$ of items together with a collection, $\cal T$, of distinct subsets of these items called tests. We assume that $\cal T$ is a test cover, i.e., for each pair of items there is a test in $\cal T$ containing exactly one of these items. The objective is to find a minimum size subcollection of $\cal T$, which is still a test cover. The generic parameterized version of {\sc Test Cover} is denoted by $p(k,n,|{\cal T}|)$-{\sc Test Cover}. Here, we are given $([n],\cal{T})$ and a positive integer parameter $k$ as input and the objective is to decide whether there is a test cover of size at most $p(k,n,|{\cal T}|)$. We study four parameterizations for {\sc Test Cover} and obtain the following: (a) $k$-{\sc Test Cover}, and $(n-k)$-{\sc Test Cover} are fixed-parameter tractable (FPT). (b) $(|{\cal T}|-k)$-{\sc Test Cover} and $(\log n+k)$-{\sc Test Cover} are W[1]-hard. Thus, it is unlikely that these problems are FPT

Experimenting with Cigarettes and Physical Activity Among Mexican Origin Youth: A Cross Sectional Analysis of the Interdependent Associations Among Sensation Seeking, Acculturation, and Gender

Sensation seeking tendencies tend to manifest during adolescence and are associated with both health-compromising behaviors and health-enhancing behaviors. The purpose of this study is to evaluate the relationship between sensation seeking and physical activity, a health-enhancing behavior, and between sensation seeking and experimenting with cigarettes, a health compromising-behavior, among a cohort of Mexican origin adolescents residing in the United States with different levels of acculturation. Methods: In 2009, 1,154 Mexican origin youth (50.5% girls, mean age 14.3 years (SD = 1.04)) provided data on smoking behavior, physical activity, linguistic acculturation, and sensation seeking. We conducted Pearson's chi(2) tests to examine the associations between categorical demographic characteristics (i.e. gender, age, country of birth and parental educational attainment) and both cigarette experimentation and physical activity and Student's t-tests to examine mean differences on the continuous variables (i.e. sensation seeking subscale) by the behaviors. We examined mean differences in the demographic characteristics, acculturation, and both behaviors for each of the sensation seeking subscales using analysis of variance (ANOVA). To examine relationships between the sensation seeking subscales, gender, and both behaviors, at different levels of acculturation we completed unconditional logistic regression analyses stratified by level of acculturation. Results: Overall, 23.3% had experimented with cigarettes and 29.0% reported being physically active for at least 60 minutes/day on at least 5 days/week. Experimenting with cigarettes and being physically active were more prevalent among boys than girls. Among girls, higher levels of sensation seeking tendencies were associated with higher levels of acculturation and experimentation with cigarettes, but not with physical activity. Among boys, higher levels of sensation seeking tendencies were associated with higher levels of acculturation, experimenting with cigarettes and being physically active. Conclusions: Our results suggest that interventions designed to prevent smoking among Mexican origin youth may need to address social aspects associated with acculturation, paying close attention to gendered manifestations of sensation seeking.National Cancer Institute CA105203, CA126988Caroline W. Law Fund for Cancer PreventionDan Duncan Family Institute for Cancer Prevention and Risk AssessmentCenter for Health Promotion and Disease Prevention Research in Underserved Population

Fundamental Cycles and Graph Embeddings

In this paper we present a new Good Characterization of maximum genus of a graph which makes a common generalization of the works of Xuong, Liu, and Fu et al. Based on this, we find a new polynomially bounded algorithm to find the maximum genus of a graph

Health Quality Control of Laboratory Anjmals 0f the Czechoslovak Academy of Sciences (CSAV)

No abstract availabl