Snca and Bdnf gene expression in the VTA and raphe nuclei of midbrain in chronically victorious and defeated male mice

The study aimed to analyze the mRNA levels of Snca and Bdnf genes in the ventral tegmental area (VTA) and raphe nuclei of the midbrain in male mice that had each won or defeated 20 encounters in daily agonistic interactions. Groups of animals that had the same winning and losing track record followed by a no-fight period for 14 days were also studied. Snca mRNA levels were increased in the raphe nuclei in the losers and in the VTA of the winners. After fighting deprivation Snca mRNA levels were decreased to the control level in both groups. Snca mRNA levels were similar to the control level in the VTA of the losers and in the raphe nuclei of the winners. However Snca gene expression was increased in these areas after no-fight period in the winners and losers in comparison with respective mRNA levels in the undeprived animals. Significant positive correlations were found between the mRNA levels of Snca and Bdnf genes in the raphe nuclei. It was concluded, that social experience affects Snca gene expression depending on brain areas and functional activity of monoaminergic systems in chronically victorious or defeated mice

Further studies of GEM performance in dense noble gases

We further study the performance of single, double and triple Gas Electron Multiplier (GEM) detectors in pure noble gases at high pressures, in the range of 1-10 atm. We confirm that light noble gases, in particular He and its mixtures with Kr, have the highest gain, reaching 10^6, and an unusual gain dependence on pressure. Effects of the number of GEMs, GEM hole diameter and pitch are investigated in detail. In He, avalanche-induced secondary scintillations are observed at high gains, using the metal photocathode. These results are relevant in the field of avalanche mechanism in noble gases and X-ray, neutron and cryogenic particle detectors.Comment: 4 pages, 4 figures. Presented at the 6th Int. Conf. on Position Sensitive Detectors, Leicester, Sept 9-13, 200

MRI measures of middle cerebral artery diameter in conscious humans during simulated orthostasis.

BACKGROUND AND PURPOSE: The relationship between middle cerebral artery (MCA) flow velocity (CFV) and cerebral blood flow (CBF) is uncertain because of unknown vessel diameter response to physiological stimuli. The purpose of this study was to directly examine the effect of a simulated orthostatic stress (lower body negative pressure [LBNP]) as well as increased or decreased end-tidal carbon dioxide partial pressure (P(ET)CO(2)) on MCA diameter and CFV. METHODS: Twelve subjects participated in a CO(2) manipulation protocol and/or an LBNP protocol. In the CO(2) manipulation protocol, subjects breathed room air (normocapnia) or 6% inspired CO(2) (hypercapnia), or they hyperventilated to approximately 25 mm Hg P(ET)CO(2) (hypocapnia). In the LBNP protocol, subjects experienced 10 minutes each of -20 and -40 mm Hg lower body suction. CFV and diameter of the MCA were measured by transcranial Doppler and MRI, respectively, during the experimental protocols. RESULTS: Compared with normocapnia, hypercapnia produced increases in both P(ET)CO(2) (from 36+/-3 to 40+/-4 mm Hg, P CONCLUSIONS: Under the conditions of this study, changes in MCA diameter were not detected. Therefore, we conclude that relative changes in CFV were representative of changes in CBF during the physiological stimuli of moderate LBNP or changes in P(ET)CO(2)

Comparative study of an activity of rat spinal ganglion cells and PC12 cells on the surfaces modified with bioadhesive polymers

We studied the adsorption of bioadhesive polymers (polyornithine, gelatin, laminin) on polystyrene surface by the use of dynamic light scattering. The contribution of biopolymers to resulting zeta potential of the modified surface was assessed. PC12 cells do not exhibit selective adhesion in the presence of foetal bovine serum. Polystyrene with adsorbed polyornithine promotes primary adhesion of PC12 cells cultured in serum-free medium with nerve growth factor. Subsequently adsorbed laminin induces spreading and differentiation of the cells into neuronal direction. Primary neurons isolated from rat spinal ganglion adhere preferentially on the polyornithine-modified surface. On the polyornithine-laminin surface neurons intensively form neuritis that correlates with proliferation of glial cells positive for S100 protein. The results show that PC12 cells and primary neurons exhibit similar response to surface material with the latter cells being more sensitive to this factor. Isolated cell culture can be used to study the relationship between neurite outgrowth and Schwann cells proliferation on different biomaterials

Study of infrared scintillations in gaseous and liquid argon - Part II: light yield and possible applications

We present here a comprehensive study of the light yield of primary and secondary scintillations produced in gaseous and liquid Ar in the near infrared (NIR) and visible region, at cryogenic temperatures. The measurements were performed using Geiger-mode avalanche photodiodes (GAPDs) and pulsed X-ray irradiation. The primary scintillation yield of the fast emission component in gaseous Ar was found to be independent of temperature in the range of 87-160 K; it amounted to 17000+/-3000 photon/MeV in the NIR in the range of 690-1000 nm. In liquid Ar at 87 K, the primary scintillation yield of the fast component was considerably reduced, amounting to 510+/-90 photon/MeV, in the range of 400-1000 nm. Proportional NIR scintillations (electroluminescence) in gaseous Ar were also observed; their amplification parameter at 160 K was measured to be 13 photons per drifting electron per kV. No proportional scintillations were observed in liquid Ar up to the electric fields of 30 kV/cm. The applications of NIR scintillations in dark matter search and coherent neutrino-nucleus scattering experiments and in ion beam radiotherapy are considered.Comment: 20 pages, 11 figures. Submitted to JINS

Light multi-GEM detector for high-resolution tracking systems

Controlled etching of copper electrodes in Gas Electron Multiplier foils allows a reduction of the material budget by more than a factor of two for a triple-GEM detector. Detectors making use of thinned foils provide performances similar to those obtained with standard devices: a gain above 10^4 for a double-GEM, with energy resolution of 27 % fwhm for 5.9 keV X-rays.Comment: Submitted to Nucl.Instr.& Meth.

Некоторые аспекты развития космического приборостроения в Украине (70-90-е гг. ΧΧ ст.)

У статті розглядається вклад вчених кафедри радіотехнічних пристроїв Одеського політехнічного університету в проектування, розробку і виготовлення наукової апаратури для дослідження фізичних характеристик міжпланетної плазми.In the article discusses the contribution of scientists cathedra of radiodevices Odessa Polytechnic University in the design, development and manufacture of scientific instruments for the study of the physical characteristics of the interplanetary plasma.В статье рассматривается вклад ученных кафедры радиотехнических устройств Одесского политехнического университета в проектирование, разработку и изготовление научной аппаратуры для исследования физических характеристик межпланетной плазмы

Higher Partial Waves in p+p->p+p+eta near Threshold

Exclusive measurements of the production of eta mesons in the p+p->p+p+eta reaction have been carried out at excess energies of 16 and 37 MeV above threshold. The deviations from phase space are dominated by the proton-proton final state interaction and this influences particularly the energy distribution of the eta meson. However, evidence is also presented at the higher energy for the existence of an anisotropy in the angular distributions of the eta meson and also of the final proton-proton pair, probably to be associated with D-waves in this system interfering with the dominant S-wave term. The sign of the eta angular anisotropy suggests that rho-exchange is important for this reaction.Comment: 16 pages, LaTeX2e, 3 EPS Figures, Updated version, Accepted for publication in Phys. Lett.

Shapes of leading tunnelling trajectories for single-electron molecular ionization

Based on the geometrical approach to tunnelling by P.D. Hislop and I.M. Sigal [Memoir. AMS 78, No. 399 (1989)], we introduce the concept of a leading tunnelling trajectory. It is then proven that leading tunnelling trajectories for single-active-electron models of molecular tunnelling ionization (i.e., theories where a molecular potential is modelled by a single-electron multi-centre potential) are linear in the case of short range interactions and "almost" linear in the case of long range interactions. The results are presented on both the formal and physically intuitive levels. Physical implications of the obtained results are discussed.Comment: 14 pages, 5 figure