53 research outputs found
OXIDE FUEL ELEMENT DEVELOPMENT. Quarterly Progress Report for the Period Ending September 30, 1970.
Westinghouse Astronuclear Laboratory contribution to the twentieth high temperature fuel committee meeting, 18--20 May 1965
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Westinghouse Astronuclear Laboratory contribution to the twentieth high temperature fuel committee meeting, 18--20 May 1965
Westinghouse Astronuclear Laboratory contribution to the seventh meeting of the particle fuels working group, May 20--21, 1964. Evaluation of fuel particles
Combating subclonal evolution of resistant cancer phenotypes
Metastatic breast cancer remains challenging to treat, and most patients ultimately progress on therapy. This acquired drug resistance is largely due to drug-refractory sub-populations (subclones) within heterogeneous tumors. Here, we track the genetic and phenotypic subclonal evolution of four breast cancers through years of treatment to better understand how breast cancers become drug-resistant. Recurrently appearing post-chemotherapy mutations are rare. However, bulk and single-cell RNA sequencing reveal acquisition of malignant phenotypes after treatment, including enhanced mesenchymal and growth factor signaling, which may promote drug resistance, and decreased antigen presentation and TNF-α signaling, which may enable immune system avoidance. Some of these phenotypes pre-exist in pre-treatment subclones that become dominant after chemotherapy, indicating selection for resistance phenotypes. Post-chemotherapy cancer cells are effectively treated with drugs targeting acquired phenotypes. These findings highlight cancer's ability to evolve phenotypically and suggest a phenotype-targeted treatment strategy that adapts to cancer as it evolves
Effect of heat treatment on phase structure and thermal conductivity of a copper-infiltrated steel
Westinghouse Astronuclear Laboratory contribution to the twenty-first high temperature fuel committee meeting, December 14--16, 1965
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