Appetite for destruction: the inhibition of glycolysis as a therapy for tuberous sclerosis complex-related tumors

The elevated metabolic requirements of cancer cells reflect their rapid growth and proliferation and are met through mutations in oncogenes and tumor suppressor genes that reprogram cellular processes. For example, in tuberous sclerosis complex (TSC)-related tumors, the loss of TSC1/2 function causes constitutive mTORC1 activity, which stimulates glycolysis, resulting in glucose addiction in vitro. In research published in Cell and Bioscience, Jiang and colleagues show that pharmacological restriction of glucose metabolism decreases tumor progression in a TSC xenograft model

Design tools in practice: instructional designers report which tools they use and why

Minimal attention has been paid by scholars to practitioners’ views of and experiences with instructional design tools. Instructional design practitioners working in diverse setting were surveyed regarding the tools they use in their practice, and interviewed regarding how they explain their choices to use the tools that they do. A survey completed by 100 instructional designers shows that they use a wide array of both digital and analog tools, many of them not specifically focused on, or limited to, the design and development of instruction. Analysis of interview narratives with 10 instructional designers surfaced themes in two categories, rationalist and situational explanations for the use of certain tools, with appropriateness (a rational explanation) and individual preference (a situational explanation) offered most frequently. These findings, and the statements of the designers, highlight the role of instrumental judgment in instructional design practice and points to implications for the education of instructional designers