68 research outputs found
Studies on tableting properties of lactose. Part III. The consolidation behaviour of sieve fractions of crystalline a-lactose\ud monohydrate
The consolidation and compaction behaviour of sieve fractions of crystalline α-lactose monohydrate were studied. From mercury porosimetry measurements tablet pore surface areas were derived. At a certain compaction load it appeared that tablets compressed from small particles were generally stronger and showed a larger surface area than compacts prepared from coarse sieve fractions. By plotting compact strength against pore surface area, a unique linear relationship was obtained. From these results it can be concluded that the actual tablet surface area, being a function of both the initial particle size and applied compaction pressure, is responsible for the compact strength
The use of a factorial design to evaluate the physical stability of tablets after storage under tropical conditions.
The use of a factorial design to evaluate the physical stability of tablets after storage under tropical conditions.
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