More order with less law: on contract enforcement, trust, and crowding

Most contracts, whether between voters and politicians or between house owners and contractors, are incomplete. “More law,” it typically is assumed, increases the likelihood of contract performance by increasing the probability of enforcement and/or the cost of breach. We examine a contractual relationship in which the first mover has to decide whether she wants to enter a contract without knowing whether the second mover will perform. We analyze how contract enforceability affects individual performance for exogenous preferences. Then we apply a dynamic model of preference adaptation and find that economic incentives have a nonmonotonic effect on behavior. Individuals perform a contract when enforcement is strong or weak but not with medium enforcement probabilities: Trustworthiness is “crowded in” with weak and “crowded out” with medium enforcement. In a laboratory experiment we test our model’s implications and find support for the crowding prediction. Our finding is in line with the recent work on the role of contract enforcement and trust in formerly Communist countries

Learning trust

We examine the effects of different forms of feedback information on the performance of markets that suffer from moral hazard problems due to sequential exchange. As orthodox theory would predict, we find that providing buyers with information about sellers' trading history boosts market performance. More surprisingly, this beneficial effect of incentives for reputation building is considerably enhanced if sellers, too, can observe other sellers' trading history. This suggests that two-sided market transparency is an important ingredient for the design of well-functioning markets that are prone to moral hazard

Democracy by Competition: Referenda and Federalism in Switzerland

Competition is not only a prerequisite for the successful working of economics but also of political coordination systems. We argue that popular referenda and federalism are the key factors in maintaining competition in the political arena. Competitive economic or political markets require free entry and exit and the absence of regulations that prevent suppliers from being successful with the best product-be it goods or services in the form of policies-and prevent citizens from choosing freel

Topoisomerase activity assays in Neurospora

DNA topoisomerases are enzymes capable of altering the topological conformation of DNA by inducing transient single (Topoisomerase I) and double strand (Topoisomerase II) breaks

Requirements for Power Hardware-in-the-Loop Emulation of Distribution Grid Challenges

The ongoing transition of low voltage (LV) power grids towards active systems requires novel evaluation and testing concepts, in particular for realistic testing of devices. Power Hardware-in-the-Loop (PHIL) evaluations are a promising approach for this purpose. This paper presents preliminary investigations addressing the systematic design of PHIL applications and their applicable stability mechanisms and gives a detailed review of the related work. A requirement analysis for emulation of grid situations demanding system services is given and the realization of a PHIL setup is demonstrated in a residential scenario, comprising a hybrid electrical energy storage system (HESS)

Status of Flat Electron Beam Production

Last year at LINAC2000 [1] we reported our initial verification of the round beam (comparable transverse emittances) to flat beam (high transverse emittance ratio) transformation described by Brinkmann, Derbenev, and Flöttmann [2]. Further analysis of our data has confirmed that a transverse emittance ratio of approximately 50 was observed. Graphics representing observational detail are included here, and future plans outlined

On the elliptical flow in asymmetric collisions and nuclear equation of state

We here present the results of elliptical flow for the collision of different asymmetric nuclei (10Ne20 +13 Al27, 18Ar40 +21 Sc45, 30Zn64 +28 Ni58, 36Kr86 +41 Nb93) by using the Quantum Molecular Dynamics (QMD) model. General features of elliptical flow are investigated with the help of theoretical simulations. The simulations are performed at different beam energies between 40 and 105 MeV/nucleon. A significant change can be seen from in-plane to out-of-plane elliptical flow of different fragments with incident energy. A comparison with experimental data is also made. Further, we predict, for the first time that, elliptical flow for different kind of fragments follow power law dependence ? C(Atot)? for asymmetric systems

PD-L1 is expressed on human platelets and is affected by immune checkpoint therapy

Cancer immunotherapy has been revolutionised by drugs that enhance the ability of the immune system to detect and fight tumors. Immune checkpoint therapies that target the programmed death-1 receptor (PD-1), or its ligand (PD-L1) have shown unprecedented rates of durable clinical responses in patients with various cancer types. However, there is still a large fraction of patients that do not respond to checkpoint inhibitors, and the challenge remains to find cellular and molecular cues that could predict which patients would benefit from these therapies. Using a series of qualitative and quantitative methods we show here that PBMCs and platelets from smokers and patients with head and neck squamous cell carcinoma (HNSCC) or lung cancer express and up-regulate PD-L1 independently of tumor stage. Furthermore, treatment with Atezolizumab, a fully humanised monoclonal antibody against PD-L1, in 4 patients with lung cancer caused a decrease in PD-L1 expression in platelets, which was restored over 20 days. Altogether, our findings reveal the expression of the main therapeutic target in current checkpoint therapies in human platelets and highlight their potential as biomarkers to predict successful therapeutic outcomes

The ZEUS Forward Plug Calorimeter with Lead-Scintillator Plates and WLS Fiber Readout

A Forward Plug Calorimeter (FPC) for the ZEUS detector at HERA has been built as a shashlik lead-scintillator calorimeter with wave length shifter fiber readout. Before installation it was tested and calibrated using the X5 test beam facility of the SPS accelerator at CERN. Electron, muon and pion beams in the momentum range of 10 to 100 GeV/c were used. Results of these measurements are presented as well as a calibration monitoring system based on a $^{60}$Co source.Comment: 38 pages (Latex); 26 figures (ps