Modelling of annular plates stability with functionally granded structure interacting with elastic heterogeneous subsoil.

This contribution deals with the modelling and analysis of stability problems for thin composite annular plates interacting with elastic heterogeneous subsoil. The object of analysis is an annular plate with a deterministic heterogeneous microstructure and the apparent properties smoothly varying along a radial direction. The aim of contribution is to formulate two macroscopic mathematical models describing stability of this plate. The considerations are based on a tolerance averaging technique. The general results are applied to the analysis of some special stability problems. The obtained results of critical forces with those obtained from finite element method are compared

Modelling of annular plates stability with functionally graded structure interacting with elastic heterogeneous subsoil

This contribution deals with the modelling and analysis of stability problems for thin composite annular plates interacting with elastic heterogeneous subsoil. The object of analysis is an annular plate with a deterministic heterogeneous microstructure and the apparent properties smoothly varying along a radial direction. The aim of contribution is to formulate two macroscopic mathematical models describing stability of this plate. The considerations are based on a tolerance averaging technique. The general results are applied to the analysis of some special stability problems. The obtained results of critical forces with those obtained from finite element method are compared

Prognostic value of daytime heart rate, blood pressure, their products and quotients in chronic heart failure

Background: Chronic heart failure (CHF) is an important epidemiological and therapeuthic issue  with poor prognosis. The aim of the study was to estimate the prognostic value of daytime heart rate (HR), blood pressure (BP), their products and quotients in patients with CHF. Methods: The study included 80 stable patients with CHF and reduced left ventricular ejection frac- tion (LVEF ≤ 35%). Physical examination, laboratory blood tests, electrocardiogram, chest X-ray, echocardiography, 6-minute walk test, telemetry monitoring and BP measurements were performed in all participants. We estimated mean daytime: BP, HR, their products and quotients. The follow-up period was 6 months. Major adverse cardiac events (MACE) included: death, cardiovascular death, hospitalization due to CHF exacerbation.  Results: The analysis involved all recruited patients with CHF (91% men) aged 59 ± 12 years, in New York Heart Association class 2.15 ± 0.57 and reduced LVEF (mean LVEF: 23 ± 6%). The 3-month and 6-month mortality rates were 4% and 6%, respectively. There was a significant correlation between diastolic blood pressure (DBP), all-cause mortality (p = 0.048) and CHF decompensation (p = 0.0004) after 3-month observation period. No relationship was found between HR or systolic blood pressure (SBP) and MACE. Both higher SBP × HR and DBP × HR products were related to lower risk of heart failure exacerbations during 6-month follow-up. None of the analyzed products or ratios had an impact on mortality in this study group.  Conclusions: Diastolic blood pressure, SBP × HR and DBP × HR products may be useful in sub- sequent heart failure exacerbation risk stratification. Moreover, DBP value may predict short-term mortality in patients with CHF.

Metabolic modulation in chronic heart failure

Trimetazydyna, pochodna piperazyny, jest od wielu lat stosowana u pacjentów z chorobą wieńcową. Lek ten hamuje metabolizm kwasów tłuszczowych i ukierunkowuje metabolizm kardiomiocytów na przemiany glukozy. Od kilku lat pojawia się coraz więcej publikacji naukowych o możliwym, korzystnym działaniu trimetazydyny u pacjentów z przewlekłą niewydolnością serca. Niektóre doniesienia sugerują, że lek ten dodany do standardowej terapii niewydolności serca może przyczyniać się do poprawy funkcji skurczowej lewej komory, wydolności fizycznej, a nawet do redukcji liczby hospitalizacji z powodu zaostrzeń i zmniejszenia śmiertelności sercowo-naczyniowej. Zbyt mała liczba prospektywnych badań z randomizacją wciąż nie pozwala na precyzyjne określenie miejsca trimetazydyny w terapii niewydolności serca. W artykule przedstawiono przegląd piśmiennictwa na temat zastosowania trimetazydyny w przewlekłej niewydolności serca.Trimetazidine, a piperazine derivate, has been used in patients with coronary artery disease for many years. It blocks metabolism of free fatty acid and promotes glucose oxidation in cardiomyocytes. There have been many reports concerning possible, favourable treatment with trimetazidine in chronic heart failure patients. Some reports suggest that addition of trimetazidine to standard heart failure treatment may improve left ventricle systolic function, exercise capacity and reduce the number of hospitalizations due to heart failure exacerbation and cardiovascular mortality. Precise determination of trimetazidine role in heart failure therapy is still not possible due to lack of prospective randomized studies. In this article we present a literature review concerning trimetazidine treatment in chronic heart failure

Si-Based Electrodes for Potentiometric Measurements of Aqueous Solutions, Journal of Telecommunications and Information Technology, 2009, nr 4

Three sensors for chemical and physical examination of aqueous solutions were presented in the paper. An Au potentiometric electrode, an AgCl chlorine ion sensor and a p-n junction thermometer were developed. Their layout and internal structure were explained in the light of the manufacturing process. The device characteristics were measured in conditions corresponding to normal operation of the devices. Basic electrical parameters of the developed structures, as well as their sensitivity to environmental parameter variation were estimated

ST-segment elevation myocardial infarction as a COVID-19 manifestation in a recent heart transplant recipient

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Four-Fermi Effective Operators in Top-Quark Production and Decay

Effects of four-Fermi-type new interactions are studied in top-quark pair production and their subsequent decays at future e^+e^- colliders. Secondary-lepton-energy distributions are calculated for arbitrary longitudinal beam polarizations. An optimal-observables procedure is applied for the determination of new parameters.Comment: Polarized e^- plus unpolarized e^+ collisions were include

Effects of trimetazidine in patients with severe chronic heart failure with reduced left ventricular ejection fraction: A prospective, randomized, open-label, cross-over study

Background: Trimetazidine (TMZ) modulates cardiac metabolism, but its use in heart failure remains controversial. The aim of the study was to evaluate the effects of TMZ on exercise capacity, left ventricular ejection fraction (LVEF), mortality, and quality of life in stable patients with heart failure with reduced left ventricular ejection fraction (HFrEF). Methods: Forty-five patients with stable advanced HFrEF treated with optimal medical therapy were randomized in a prospective, single-center, open-label, cross-over study of trimetazidine (35 mg b.i.d.) on top of standard medical therapy or standard pharmacotherapy for two periods of 30 days and one period of 6 months. Initially and at the end of each period all patients underwent the following: exercise testing, six-minute walk test (6MWT), two-dimensional-echocardiography, and quality of life assessment. Results: The mean age of patients was 58.2 ± 10.6 years. Etiology of HFrEF was ischemic in 66.6% of patients. After 6 months no significant changes were observed in either group with regards to peak VO2 uptake, 6MWT, LVEF, or quality of life. TMZ had no effect on mortality or cardiovascular events. Conclusions: The additional use of TMZ on top of standard medical therapy in stable advanced HFrEF patients was not associated with significant changes in mortality, exercise capacity, LVEF, or quality of life