Evaluation of the current state of aquatic ecosystems and the problems of the protection of biological resources during development of kruzenshternskoye gcf

The results of studies of the current state of freshwater ecosystems and their biotic components in the western part of the Yamal Peninsula are presented in the article. Based on the evaluation of the structure of communities of phytoplankton, zooplankton, benthos, and whitefishes, the range of problems related to the protection of biological resources during the development of the Kruzenshternskoye gas field is defined. The data on species composition and quantitative indicators of hydrobionts of different types of waterbodies and watercourses in the lower reaches of the Mordyyakha and Naduyyakha Rivers basins is the basis for environmental monitoring of water objects during development and exploitation of the Kruzenshternskoye gas field. Estimation of the fish fauna state and their food base in the territory of the Kruzenshternskoye GCF according to the monitoring program is present. The river delta zones are the most important feeding areas of the salmonid and whitefishes valuable fish species in the territory of Kruzenshternskoye GCF. In cases where water bodies and watercourses are not completely demolished for the construction of GCF facilities, changes of quantitative and qualitative characteristics of communities of hydrobionts after the end of operations are reversible. River ecosystems are restored within a shorter period of time in comparison to lacustrine ones. Proposals for the protection of fisheries resources and monitoring of aquatic ecosystems on the basis of comprehensive studies are reported. Recommendations on reducing the anthropogenic impact on aquatic ecosystems in the development period are present. The results of the investigation were used in the development of the environmental protection part of the Kruzenshternskoye deposit project. Anthropogenic disturbances present now on the gas deposit territory of Kruzenshternskoye does not influence the aquatic ecosystems.The article have been prepared within the Project of the Presidium of the Russian Academy of Sciences № 12-P-47-2013 and "The Arctic" Project of the Presidium of the Ural Branch of the Russian Academy of Sciences № 12-4-3-012

Child and mobile phone: tips for parents

A guidance for parents is provided on the organization for a child a mobile phone useПриводятся рекомендации родителям по организации для ребенка пользования мобильным телефоно

Syntaxin 3B is essential for the exocytosis of synaptic vesicles in ribbon synapses of the retina.

Ribbon synapses of the vertebrate retina are specialized synapses that release neurotransmitter by synaptic vesicle exocytosis in a manner that is proportional to the level of depolarization of the cell. This release property is different from conventional neurons, in which the release of neurotransmitter occurs as a short-lived burst triggered by an action potential. Synaptic vesicle exocytosis is a calcium regulated process that is dependent on a set of interacting synaptic proteins that form the so-called SNARE (soluble N-ethylmaleimide sensitive factor attachment protein receptor) complex. Syntaxin 3B has been identified as a specialized SNARE molecule in ribbon synapses of the rodent retina. However, the best physiologically-characterized neuron that forms ribbon-style synapses is the rod-dominant or Mb1 bipolar cell of the goldfish retina. We report here the molecular characterization of syntaxin 3B from the goldfish retina. Using a combination of reverse transcription (RT) polymerase chain reaction (PCR) and immunostaining with a specific antibody, we show that syntaxin 3B is highly enriched in the plasma membrane of bipolar cell synaptic terminals of the goldfish retina. Using membrane capacitance measurements we demonstrate that a peptide derived from goldfish syntaxin 3B inhibits synaptic vesicle exocytosis. These experiments demonstrate that syntaxin 3B is an important factor for synaptic vesicle exocytosis in ribbon synapses of the vertebrate retina

Current problems of modern choice execution: choice theatralization

The article discusses the theoretical aspects of the problem of finding ways to develop choral performance in the conditions of the modern cultural and educational environment. The purpose of the materials presented in the publication is to actualize the appeal to choral theatricalization as an effective means of awakening and developing the interest of students in collective singing activities. The concept of “choral theatricalization” and significant aspects of attracting young people to choral performance are analyzed. The priority is determined by the reliance on the following components of the collective musical and creative activity: perceptual (features of musical perception, empathy, understanding musical information, its semantic and emotional content); communicative (dialogue between performers and authors of a musical work, choirmaster and singers of the choir, members of the choir, the performing team and the audience); interactive (creative interaction between all participants of the artistic and creative process).В статье рассматриваются теоретические аспекты проблемы поиска путей развития хорового исполнительства в условиях современной культурно-образовательной среды. Целью представленных в публикации материалов является актуализация обращения к хоровой театрализации как эффективному средству пробуждения и развития интереса учащейся молодежи к коллективной певческой деятельности. Анализируются понятие «хоровая театрализация» и значимые аспекты привлечения молодежи к хоровому исполнительству

Search for the Radiative Capture d+d->^4He+\gamma Reaction from the dd\mu Muonic Molecule State

A search for the muon catalyzed fusion reaction dd --> ^4He +\gamma in the dd\mu muonic molecule was performed using the experimental \mu CF installation TRITON and NaI(Tl) detectors for \gamma-quanta. The high pressure target filled with deuterium at temperatures from 85 K to 800 K was exposed to the negative muon beam of the JINR phasotron to detect \gamma-quanta with energy 23.8 MeV. The first experimental estimation for the yield of the radiative deuteron capture from the dd\mu state J=1 was obtained at the level n_{\gamma}\leq 2\times 10^{-5} per one fusion.Comment: 9 pages, 3 Postscript figures, submitted to Phys. At. Nuc

Deregulated calcium signaling in blood cancer: Underlying mechanisms and therapeutic potential

Intracellular calcium signaling regulates diverse physiological and pathological processes. In solid tumors, changes to calcium channels and effectors via mutations or changes in expression affect all cancer hallmarks. Such changes often disrupt transport of calcium ions (Ca$^{2+}$) in the endoplasmic reticulum (ER) or mitochondria, impacting apoptosis. Evidence rapidly accumulates that this is similar in blood cancer. Principles of intracellular Ca$^{2+}$ signaling are outlined in the introduction. We describe different Ca$^{2+}$-toolkit components and summarize the unique relationship between extracellular Ca$^{2+}$ in the endosteal niche and hematopoietic stem cells. The foundational data on Ca$^{2+}$ homeostasis in red blood cells is discussed, with the demonstration of changes in red blood cell disorders. This leads to the role of Ca$^{2+}$ in neoplastic erythropoiesis. Then we expand onto the neoplastic impact of deregulated plasma membrane Ca$^{2+}$ channels, ER Ca$^{2+}$ channels, Ca$^{2+}$ pumps and exchangers, as well as Ca$^{2+}$ sensor and effector proteins across all types of hematologic neoplasms. This includes an overview of genetic variants in the Ca$^{2+}$-toolkit encoding genes in lymphoid and myeloid cancers as recorded in publically available cancer databases. The data we compiled demonstrate that multiple Ca$^{2+}$ homeostatic mechanisms and Ca$^{2+}$ responsive pathways are altered in hematologic cancers. Some of these alterations may have genetic basis but this requires further investigation. Most changes in the Ca$^{2+}$-toolkit do not appear to define/associate with specific disease entities but may influence disease grade, prognosis, treatment response, and certain complications. Further elucidation of the underlying mechanisms may lead to novel treatments, with the aim to tailor drugs to different patterns of deregulation. To our knowledge this is the first review of its type in the published literature. We hope that the evidence we compiled increases awareness of the calcium signaling deregulation in hematologic neoplasms and triggers more clinical studies to help advance this field

Search for Low Mass Exotic mesonic structures. Part II: attempts to understand the experimental results

Our previous paper, part I of the same study, shows the different experimental spectra used to conclude on the genuine existence of narrow, weakly excited mesonic structures, having masses below and a little above the pion (M=139.56 MeV) mass. This work \cite{previous} was instigated by the observation, in the $\Sigma^{+}$ disintegration: $\Sigma^{+}\to$pP$^{0}$, P$^{0}\to\mu^{-}\mu^{+}$ \cite{park}, of a narrow range of dimuon masses. The authors conclude on the existence of a neutral intermediate state P$_{0}$, with a mass M=214.3 MeV $\pm$ 0.5 MeV. We present here some attempts to understand the possible nature of the structures observed in part I.Comment: 3 pages, 4 figures. Follows 0710.1796. Both replace arXiv:0707.1261 [nucl-ex