Acceptance and Factors Influencing Acceptance of COVID-19 Vaccine in a Romanian Population

COVID-19 vaccination has been recognized as one of the most effective ways to overcome the current SARS-CoV-2 pandemic. However, the success of this effort relies on national vaccination programmes. In May 2021, we surveyed 1552 people from Romania to determine acceptance rates and factors influencing acceptance of a COVID-19 vaccine. Of these, 39.2% of participants reported that they were vaccinated and 25.6% desired vaccination; nonetheless, 29.5% expressed opposition to vaccination. Concerning vaccination refusal, the top justification given by respondents is that the vaccine is insufficiently safe and there is a risk of serious side effects (84.4%). A higher rate of vaccination refusal was observed among female gender, younger age, and lower educational level. Refusal was also associated with unemployment, being in a relationship, and having a decrease in income during the pandemic. People who are constantly informed by specialized medical staff have a statistically significant higher vaccination rate, while people who choose to get information from friends, family, and co-workers have the strongest intention of avoiding the vaccine. Current levels of vaccine are insufficient to achieve herd immunity of 67%. It is mandatory to understand the aspects that define and establish confidence and to craft nationwide interventions appropriately

Sleepless Pandemic: A Cross-Sectional Analysis of Insomnia Symptoms among Professionally Active Romanians during the COVID-19 Pandemic

Background: The COVID-19 pandemic put considerable strain on individual mental health. The current study aimed to determine the prevalence and severity of insomnia symptoms among students and employees during this period. Methods: This paper is a cross-sectional analysis using convenience sampling. A web-based anonymous survey was developed and included questions about socio-demographic characteristics, contact with COVID-19, and the Athens Insomnia Scale. Results: 620 participants, 331 students, and 289 employees were included in the final sample. According to the current findings, 21.29% (n = 132) of participants met the criteria for insomnia, and 39.03% (n = 242) met the criteria for mild sleep disturbances. Conclusions: Although respondents reported an increased prevalence of sleep disorders, these changes were not directly related to the presence or severity of the infection but rather to a variety of socio-demographic and lifestyle-related variables. Students associated more frequently with the next-day consequences of insomnia (overall functioning and sleepiness during the day), while for employees, the most prevalent were awakenings during the night and early morning awakenings. Furthermore, sleep difficulties were more prevalent in women, single people, sedentary people, and those with psychiatric disorders

Genetic Characterization of Dilated Cardiomyopathy in Romanian Adult Patients

Dilated cardiomyopathy (DCM) represents a group of disorders affecting the structure and function of the heart muscle, leading to a high risk of heart failure and sudden cardiac death (SCD). DCM frequently involves an underlying genetic etiology. Genetic testing is valuable for risk stratification, treatment decisions, and family screening. Romanian population data on the genetic etiology of DCM are lacking. We aimed to investigate the genetic causes for DCM among Romanian adult patients at tertiary referral centers across the country. Clinical and genetic investigations were performed on adult patients presenting to tertiary hospitals in Romania. The genetic investigations used next-generation sequencing panels of disease-associated DCM genes. A total of 122 patients with DCM underwent genetic testing. The mean age at DCM diagnosis was 41.6 ± 12.4 years. The genetic investigations identified pathogenic or likely pathogenic variants in 50.8% of participants, while 25.4% had variants of unknown significance. Disease-causing variants in 15 genes were identified in people with DCM, with 31 previously unreported variants. Variants in TTN, LMNA, and DSP explained 75% of genetic causes for DCM. In total, 52.4% of patients had a family history of DCM/SCD. Left ventricular ejection fraction of <35% was observed in 41.9% of patients with disease-causing variants and 55% with negative or uncertain findings. Further genotype-phenotype correlations were explored in this study population. The substantial percentage (50.8%) of disease-causing variants identified in patients with DCM acknowledges the importance of genetic investigations. This study highlights the genetic landscape in genes associated with DCM in the Romanian population