Cardiac rehabilitation for older patients with cardiovascular pathology using robotic systems – A survey

In the last decades, we have witnessed a drastic increase in the proportion of elders in the western countries, and more than a third of worldwide population dies because of ardiovascular diseases. The elderly patients with cardiovascular diseases, but not only, are frail and need constant assistance, and so the healthcare system will slowly become incapable of properly address all the patients’ medical problems and rehabilitation issues, while aiming towards a continuous increase of the life quality. The rehabilitation robotic systems have the potential to stimulate and support the re-learning of the functional motor pattern of over-ground walking in an optimal manner while increasing patient’s motivation, which constitutes a crucial element in the subject's cardiac recovery. Thus, the present article aims at reviewing the robotic systems available for cardiac rehabilitation in elders with cardiac pathology

Systematic Integration of Innovation in Process Improvement Projects Using the Enhanced Sigma-TRIZ Algorithm and Its Effective Use by Means of a Knowledge Management Software Platform

In an evolving, highly turbulent and uncertain socio-economic environment, organizations must consider strategies of systematic and continuous integration of innovation within their business systems, as a fundamental condition for sustainable development. Adequate methodologies are required in this respect. A mature framework for integrating innovative problem solving approaches within business process improvement methodologies is proposed in this paper. It considers a TRIZ-centred algorithm in the improvement phase of the DMAIC methodology. The new tool is called enhanced sigma-TRIZ. A case study reveals the practical application of the proposed methodology. The integration of enhanced sigma-TRIZ within a knowledge management software platform (KMSP) is further described. Specific developments to support processes of knowledge creation, knowledge storage and retrieval, knowledge transfer and knowledge application in a friendly and effective way within the KMSP are also highlighted.Process Innovation, Knowledge Management Software Platform, Innovative Problem Solving Methodology, sigma-TRIZ, DMAIC

Reconfigurability Function Deployment in Software Development

In the forthcoming highly dynamic and complex business environment high-speed and cost-effective development of software applications for targeting a precise, unique and momentary set of requirements (no more-no less) associated to a customized business case will bring sig-nificant benefits both for producers and users. This requires a life cycle change-oriented ap-proach in software development. In this respect, designing software with intrinsic evolutionary resources for reconfiguration represents the sound approach. A methodology for concurrent deployment of reconfigurability characteristics in software applications is introduced in this paper. Its potential is exemplified in a case study dealing with web-based software tools to support systematic product innovation projects.Reconfigurability, Software Development, Innovation, TRIZ, RAD

Systematic Integration of Innovation in Process Improvement Projects Using the Enhanced Sigma-TRIZ Algorithm and Its Effective Use by Means of a Knowledge Management Software Platform

In an evolving, highly turbulent and uncertain socio-economic environment, organizations must consider strategies of systematic and continuous integration of innovation within their business systems, as a fundamental condition for sustainable development. Adequate methodologies are required in this respect. A mature framework for integrating innovative problem solving approaches within business process improvement methodologies is proposed in this paper. It considers a TRIZ-centred algorithm in the improvement phase of the DMAIC methodology. The new tool is called enhanced sigma-TRIZ. A case study reveals the practical application of the proposed methodology. The integration of enhanced sigma-TRIZ within a knowledge management software platform (KMSP) is further described. Specific developments to support processes of knowledge creation, knowledge storage and retrieval, knowledge transfer and knowledge application in a friendly and effective way within the KMSP are also highlighted

Smart Deployment of Demonstrators into Successful Commercial Solutions

AbstractProduct or service concepts based on emerging technologies are usually results of research projects, be they performed by academic groups or by research departments of companies. Many times, the prototypes or demonstrators that result from such projects are supposed to evolve into commercial products or services, but – at least in the first stage - there are more focus on proving key features of a technology, or the effectiveness / efficiency / applicability of various concepts or algorithms. However, evolving into commercial products is many times at least as challenging as building the prototypes. In case of software-based projects, this means changes in architecture, a lot of code rewriting and important usability improvements. This paper introduces a software-concept product design algorithm which aims to minimize the effort required in turning a demonstrator into a commercial product. This is done by generating two functionality sets: a pure demonstrator and a pure commercial one, then generating a hybrid functionality set with the corresponding architecture, and then assessing each functionality for the demonstrator and the commercial version in terms of development and improvement effort. Through iterations, in which the original functionality sets are improved, the difference between the two perspectives will be reduced until it gets below a reasonable limit in terms of effort. The paper presents a case study in which the algorithm is applied for planning a software platform for supporting SMEs in their innovation processes

Cardiac rehabilitation protocols outcome in frail patients undergoing transcatheter aortic valve implantation

The degenerative aortic stenosis (AS) is the most frequent valvular disease in the elderly (over 75 years), and its severe form is found in 12.4% associated with a low survival rate at 5 years (15-50%). These patients are categorised as frail and the only possible choice of treatment is transcatheter aortic valve implantation (TAVI). When cardiac rehabilitation programs (CRP) were introduced after TAVI, they had a positive impact on clinical outcome, increasing the quality of life and decreasing morbidity and mortality, especially in the elderly with high frailty score. This review underlines the utility of objective and functional frailty assessment in elderly patients with severe AS, before and after TAVI. Inclusion of these patients in complex and individually designed CRP could improve both QoL and short and long term outcome. Apart from exercise recommendation, a complete and ideal CRP should include nutrition counselling, occupational therapy, and psychological counselling to ensure psychosocial health, as well as social worker counselling. CRP could prevent and reduce severity of frailty by improving/increasing mobility, muscle mass and cognitive function. Further studies should aim at appraising long-term effects and prognostic relevance of CRP in frail patients undergoing TAVI

Reconfigurability Function Deployment in Software Development

In the forthcoming highly dynamic and complex business environment high-speed and cost-effective development of software applications for targeting a precise, unique and momentary set of requirements (no more-no less) associated to a customized business case will bring sig-nificant benefits both for producers and users. This requires a life cycle change-oriented ap-proach in software development. In this respect, designing software with intrinsic evolutionary resources for reconfiguration represents the sound approach. A methodology for concurrent deployment of reconfigurability characteristics in software applications is introduced in this paper. Its potential is exemplified in a case study dealing with web-based software tools to support systematic product innovation projects

Histological changes in the vulva and vagina from ovariectomised rats undergoing oestrogen treatment

Background: The purpose of this study was to assess the histological changes occurring in the vagina and vulva in ovariectomised female rats, as well as the response to the administration of injectable oestrogens. Material and methods: We used 30 female Wistar white rats, distributed as follows: group 1 — the control group, group 2 — the operated but untreated rats, and groups 3, 4 and 5 — operated rats, to which oestrogenic treatment was administered (Estradiol, Estradurin, Sintofolin) at a dosage of 0.2 mg/rat/day. After 14 days of treatment, all animals were sacrificed and vaginal and vulvar biopsies were taken from all groups. Results: In group 2, we encountered structural changes of the vaginal mucosa, with severe atrophy and alterations in the thickness of the vagina and vulva. In groups 3, 4 and 5 we found marked hyperplasia of the vaginal and vulvar epithelium, eosinophilic and mast cell infiltration in the chorion. Conclusions: Our study proves that the histopathological changes during anoestrus after administration of oestrogens are cell hyperplasia, thickening of the superficial mucosal layer, eosinophilic and mast cells infiltrations, and chorionic congestion. Furthermore, we demonstrated that Estradiol therapy induces the most evident histological changes when compared to synthetic oestrogens such as Estradurin or Sintofolin.

Home-Based Robotic Upper Limbs Cardiac Telerehabilitation System

This article proposes a new, improved home-based cardiac telerehabilitation system enhanced by a robotic and Virtual Reality module for cardiac patients to be used in their rehabilitation program. In this study, a novel strategy was used to integrate existing equipment and applications with newly developed ones, with the aim of reducing the need for technical skills of patients using remote control. Patients with acute or chronic heart diseases require long-term, individualized rehabilitation in order to promote their motor recovery and maintain an active and independent lifestyle. This will be accomplished by creating a system for at-home cardiac telerehabilitation augmented by a VR and cobot systems, which can be used long-term at home by each individual patient. In the pre-feasibility study carried out on healthy volunteers familiar with software applications and robotic systems, we demonstrate that RoboTeleRehab could be technically feasible both hardware and software