Cleaved surface of i-AlPdMn quasicrystals: Influence of the local temperature elevation at the crack tip on the fracture surface roughness

Roughness of i-AlPdMn cleaved surfaces are presently analysed. From the atomic scale to 2-3 nm, they are shown to exhibit scaling properties hiding the cluster (0.45 nm) aperiodic structure. These properties are quantitatively similar to those observed on various disordered materials, albeit on other ranges of length scales. These properties are interpreted as the signature of damage mechanisms occurring within a 2-3 nm wide zone at the crack tip. The size of this process zone finds its origin in the local temperature elevation at the crack tip. For the very first time, this effect is reported to be responsible for a transition from a perfectly brittle behavior to a nanoductile one.Comment: 8 page

On using pretext tasks to learn representations from network logs

Learning meaningful representations from network data is critical to ease the adoption of AI as a cornerstone to process network logs. Since a large portion of such data is textual, Natural Language Processing (NLP) appears as an obvious candidate to learn their representations. Indeed, the literature proposes impressive applications of NLP applied to textual network data. However, in the absence of labels, objectively evaluating the goodness of the learned representations is still an open problem. We call for a systematic adoption of domain-specific pretext tasks to select the best representation from network data. Relying on such tasks enables us to evaluate different representations on side machine learning problems and, ultimately, unveiling the best candidate representations for the more interesting downstream tasks for which labels are scarce or unavailable. We apply pretext tasks in the analysis of logs collected from SSH honeypots. Here, a cumbersome downstream task is to cluster events that exhibit a similar attack pattern. We propose the following pipeline: first, we represent the input data using a classic NLP-based approach. Then, we design pretext tasks to objectively evaluate the representation goodness and to select the best one. Finally, we use the best representation to solve the unsupervised task, which uncovers interesting behaviours and attack patterns. All in all, our proposal can be generalized to other text-based network logs beyond honeypots

Origin of the Universal Roughness Exponent of Brittle Fracture Surfaces: Correlated Percolation in the Damage Zone

We suggest that the observed large-scale universal roughness of brittle fracture surfaces is due to the fracture process being a correlated percolation process in a self-generated quadratic damage gradient. We use the quasi-static two-dimensional fuse model as a paradigm of a fracture model. We measure for this model, that exhibits a correlated percolation process, the correlation length exponent nu approximately equal to 1.35 and conjecture it to be equal to that of uncorrelated percolation, 4/3. We then show that the roughness exponent in the fuse model is zeta = 2 nu/(1+2 nu)= 8/11. This is in accordance with the numerical value zeta=0.75. As for three-dimensional brittle fractures, a mean-field theory gives nu=2, leading to zeta=4/5 in full accordance with the universally observed value zeta =0.80.Comment: 4 pages RevTeX

Permeability of self-affine rough fractures

The permeability of two-dimensional fractures with self-affine fractal roughness is studied via analytic arguments and numerical simulations. The limit where the roughness amplitude is small compared with average fracture aperture is analyzed by a perturbation method, while in the opposite case of narrow aperture, we use heuristic arguments based on lubrication theory. Numerical simulations, using the lattice Boltzmann method, are used to examine the complete range of aperture sizes, and confirm the analytic arguments.Comment: 11 pages, 9 figure

Single-crystal elasticity of majoritic garnets: stagnant slabs and thermal anomalies at the base of the transition zone

The elastic properties of two single crystals of majoritic garnet (Mg3.24Al1.53Si3.23O12 and Mg3.01Fe0.17Al1.68Si3.15O12), have been measured using simultaneously single-crystal X-ray diffraction and Brillouin spectroscopy in an externally heated diamond anvil cell with Ne as pressure transmitting medium at conditions up to 3c30 GPa and 3c600 K. This combination of techniques makes it possible to use the bulk modulus and unit-cell volume at each condition to calculate the absolute pressure, independently of secondary pressure calibrants. Substitution of the majorite component into pyrope garnet lowers both the bulk (Ks) and shear modulus (G). The substitution of Fe was found to cause a small but resolvable increase in Ks that was accompanied by a decrease in 02Ks/ 02P, the first pressure derivative of the bulk modulus. Fe substitution had no influence on either the shear modulus or its pressure derivative. The obtained elasticity data were used to derive a thermo-elastic model to describe Vs and Vp of complex garnet solid solutions. Using further elasticity data from the literature and thermodynamic models for mantle phase relations, velocities for mafic, harzburgitic and lherzolitic bulk compositions at the base of Earth's transition zone were calculated. The results show that Vs predicted by seismic reference models are faster than those calculated for all three types of lithologies along a typical mantle adiabat within the bottom 150 km of the transition zone. The anomalously fast seismic shear velocities might be explained if laterally extensive sections of subducted harzburgite-rich slabs pile up at the base of the transition zone and lower average mantle temperatures within this depth range

Management of tree diversity in agricultural landscapes around Mabira Forest

Abstract As natural forests contract, farming systems become increasingly important to landscape biodiversity conservation, yet assets and limits of their contribution are insufficiently documented. A sound understanding of farmer strategies in the management of on-farm tree biodiversity is also critical to landscape approaches for biodiversity conservation and livelihood improvement. Diversity and management of woody species were surveyed in 105 farms around Mabira Forest in South-Central Uganda. Farms were selected according to distance to forest, landscape axis, gender, wealth, and specialized forest use of household heads. Farmer management has a strong influence on tree diversity in the coffee-banana systems around Mabira Forest. This is reflected in the relatively high number of planted and exotic species at the levels of farm niche, farm and landscape. Both the number of years under cultivation and farmer involvement in specialized forest use were conducive to higher species diversity. Gender, wealth and tenure status did not influence tree diversity. Variation in on-farm species richness was noted between landscape axes radiating out of the forest rather than concentric distance categories. Farming systems around Mabira Forest Reserve provide a key complementary rather than substitute tree diversity refuge and can be managed to enhance overall landscape biodiversity

Dasabuvir and Ombitasvir/Paritaprevir/Ritonavir with or without Ribavirin in Patients with HIV-HCV Coinfection. Real Life Interim Analysis of an Italian Multicentre Compassionate Use Program

Background and Aims: An HCV cure is now possible in a large proportion of HIV-HCV patient. We present real life results of a compassionate use program promoted by SIMIT (Infectious and Tropical Diseases Italian Society) of Dasabuvir and Ombitasvir/Paritaprevir/Ritonavir ± Ribavirin for 12 weeks in 213 HIV-HCV genotype 1 patients. Data on efficacy and tolerability of this strategy in HIV patients have been reported until now only in 43 non cirrhotic HIV subjects

IL-10 correlates with the expression of carboxypeptidase B2 and lymphovascular invasion in inflammatory breast cancer: The potential role of tumor infiltrated macrophages

Pro-carboxypeptidase B2 (pro-CPB2) or thrombin-activatable fibrinolysis inhibitor (TAFI) is a glycoprotein encoded by the CPB2 gene and deregulated in several cancer types, including breast cancer. Thrombin binding to thrombomodulin (TM), encoded by THBD, is important for TAFI activation. CPB2 gene expression is influenced by genetic polymorphism and cytokines such as interleukin 10 (IL-10). Our previous results showed that tumor infiltrating monocytes/macrophages (CD14+/CD16+) isolated from inflammatory breast cancer (IBC) patients’ secrete high levels of IL-10. The aim of the present study is to test genetic polymorphism and expression of CPB2 in healthy breast tissues and carcinoma tissues of non-IBC and IBC patients. Furthermore, to investigate whether IL-10 modulates the expression of CPB2 and THBD in vivo and in-vitro. We tested CPB2 Thr325Ile polymorphism using restriction fragment length polymorphism, (RFLP) technique in healthy and carcinoma breast tissues. The mRNA expression of CPB2, THBD and IL10 were assessed by RT-qPCR. Infiltration of CD14+ cells was assessed by immunohistochemistry. In addition, we investigated the correlation between infiltration of CD14+ cells and expression of IL10 and CPB2. Furthermore, we correlated IL10 expression with the expression of both CPB2 and THBD in breast carcinoma tissues. Finally, we validated the role of recombinant IL-10 in regulating the expression of CPB2 and THBD using different breast cancer cell lines. Our results showed that CPB2 genotypes carrying the high-risk allele [Thr/Ile (CT) and Ile/Ile (TT)] were more frequent in both IBC and non-IBC patients compared to control group. CPB2 genotypes did not show any statistical correlation with CPB2 mRNA expression levels or patients’ clinical pathological properties. Interestingly, CPB2 and IL10 expression were significantly higher and positively correlated with the incidence of CD14+ cells in carcinoma tissues of IBC as compared to non-IBC. On the other hand, THBD expression was significantly lower in IBC carcinoma versus non-IBC tissues. Based on molecular subtypes, CPB2 and IL10 expression were significantly higher in triple negative (TN) as compared to hormonal positive (HP) carcinoma tissues of IBC. Moreover, CPB2 expression was positively correlated with presence of lymphovascular invasion and the expression of IL10 in carcinoma tissues of IBC patients. Furthermore, recombinant human IL-10 stimulated CPB2 expression in SUM-149 (IBC cell line) but not in MDA-MB-231 (non-IBC cell line), while there was no significant effect THBD expression. In conclusion, carcinoma tissues of IBC patients are characterized by higher expression of CPB2 and lower expression of THBD. Moreover, CPB2 positively correlates with IL10 mRNA expression, incidence of CD14+ cells and lymphovascular invasion in IBC patients. IL-10 stimulated CPB2 expression in TN-IBC cell line suggests a relevant role of CPB2 in the aggressive phenotype of IBC

Identification of Periostin as a Critical Marker of Progression/Reversal of Hypertensive Nephropathy

Progression of chronic kidney disease (CKD) is a major health issue due to persistent accumulation of extracellular matrix in the injured kidney. However, our current understanding of fibrosis is limited, therapeutic options are lacking, and progressive degradation of renal function prevails in CKD patients. Uncovering novel therapeutic targets is therefore necessary