Study on Tool Path Optimization in Multi-axis NC Machining

This paper presents a new generation algorithm for tool path based on the optimization of traditional algorithms. Then, the tool path on an impeller is generated with UG software, and it is used to make contrasts and verifications for the effect of optimization. Finally, VERICUT software with the function of the simulating on the whole manufacturing process is utilized to verify the feasibility of the optimized algorithm

Study on Tool Path Optimization in Multi-axis NC Machining

This paper presents a new generation algorithm for tool path based on the optimization of traditional algorithms. Then, the tool path on an impeller is generated with UG software, and it is used to make contrasts and verifications for the effect of optimization. Finally, VERICUT software with the function of the simulating on the whole manufacturing process is utilized to verify the feasibility of the optimized algorithm

Spatiotemporal transcriptomic atlas reveals the dynamic characteristics and key regulators of planarian regeneration

Abstract Whole-body regeneration of planarians is a natural wonder but how it occurs remains elusive. It requires coordinated responses from each cell in the remaining tissue with spatial awareness to regenerate new cells and missing body parts. While previous studies identified new genes essential to regeneration, a more efficient screening approach that can identify regeneration-associated genes in the spatial context is needed. Here, we present a comprehensive three-dimensional spatiotemporal transcriptomic landscape of planarian regeneration. We describe a pluripotent neoblast subtype, and show that depletion of its marker gene makes planarians more susceptible to sub-lethal radiation. Furthermore, we identified spatial gene expression modules essential for tissue development. Functional analysis of hub genes in spatial modules, such as plk1, shows their important roles in regeneration. Our three-dimensional transcriptomic atlas provides a powerful tool for deciphering regeneration and identifying homeostasis-related genes, and provides a publicly available online spatiotemporal analysis resource for planarian regeneration research