Rapid evolution of the CD8+ TCR repertoire in neonatal mice

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Phosphatidylinositol 3-kinase p110d isoform regulates CD8+ T cell responses during acute viral and intracellular bacterial infections

The p110d isoform of PI3K is known to play an important role in immunity, yet its contribution to CTL responses has not been fully elucidated. Using murine p110d-deficient CD8+ T cells, we demonstrated a critical role for the p110d subunit in the generation of optimal primary and memory CD8+ T cell responses. This was demonstrated in both acute viral and intracellular bacterial infections in mice. We show tha